Proliant ml350 server

We used logistic regressions to examine the relationship between LBs, age and sex using a Bonferroni correction for multiple comparisons (0.05/17 regions=0.003). We employed separate logistic regression models controlling for age, sex and education, to document the association of postmortem indices with LBs in cerebrum and brainstem regions based on the Braak stages and in the spinal cord. In cases with LBs in the cerebrum or brainstem, we employed Pearson's Chi-squared test with Yates' continuity correction to determine whether the presence of parkinsonism and nigral neuronal loss varied with spinal LBs. Since the current study was focused on delineating the clinical heterogeneity of LBs in older adults without a clinical diagnosis of PD, cases with a clinical diagnosis of PD were excluded from our primary analyses. We repeated these analyses adding in the cases with PD. All analyses were carried out using SAS/STAT software Version 9 (SAS Institute Inc., Cary, NC) on a Hewlett Packard ProLiant ML350 server running LINUX. (40 )

We examined the bivariate associations of spinal arteriolosclerosis and other spinal and brain post mortem indices and vascular disease and risk factors. The global parkinsonian sign score had a positively skewed distribution and was subjected to a square root transformation; the transformed scores were used in all analyses. We used a series of regression models to document the association of post-mortem indices with the severity of parkinsonian proximate to death and included terms for age, sex, and for the time from the last valid exam proximate to death. To quantify interrater reliability, weighted kappas assigned partial weight (0.9) to adjacent raters. All analyses were carried out using SAS/STAT software Version 9.3 (SAS Institute Inc., Cary, NC) on a Hewlett Packard ProLiant ML350 server running LINUX.¹² Statistical significance is recognized when p<0.05.