Nu j immuno compromised mice

Manufactured by Jackson ImmunoResearch

Nu/J immuno-compromised mice are a laboratory mouse model developed by Jackson ImmunoResearch. These mice have a genetic mutation that results in a deficiency of T and B cells, leading to an impaired immune system. The Nu/J mice can be used in various biomedical research applications that require an immunocompromised animal model.

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Lab products found in correlation

Fvb n, by Jackson ImmunoResearch (1 mentions) Fvb n, by Taconic Biosciences (1 mentions) B6n cg tg krt14 cre 1amc j, by Jackson ImmunoResearch (1 mentions) C57bl 6, by Jackson ImmunoResearch (1 mentions)

2 protocols using nu j immuno compromised mice

Xenograft Mouse Model for Breast Cancer

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All animal experiments were approved by the LSU Health Sciences Center – New Orleans Institutional Animal Care and Use Committee and were in accordance with the NIH/NCI guidelines for use of animals in cancer research. Male Nu/J immuno-compromised mice (25–35 g) were purchased from Jackson Labs (www.jax.org; #002019) and housed in groups of 5 with ad libitum access to mouse chow and water. The mice were maintained in a temperature and humidity controlled colony with a 12/12 hr light/dark cycle. Xenografts of MDA-MB-231 cells were established by s.c. injection of 4–5 million cells suspended in 50% DMEM/50% matrigel (Corning, Inc., www.corning.com: #356237) into the dorsal trunk region between the scapulae.

Gould HJ I.I.I., Norleans J., Ward T.D., Reid C, & Paul D. (2018). Selective lysis of breast carcinomas by simultaneous stimulation of sodium channels and blockade of sodium pumps. Oncotarget, 9(21), 15606-15615.

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Conditional CD200 Knockout Mice

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Mice containing a loxP-flanked Cd200 conditional allele (Cd200^fl) were re-derived from frozen sperm (B6NTac;B6N-Cd200^{tm1a(KOMP)Wtsi}/H) (EUCOMM MRC Harwell Repository). Mutant mice exhibiting germline Cd200^fl transmission were backcrossed ten generations onto a FVB/N genetic background (Taconic Biosciences). Epidermal-targeted Cd200 conditional null mice were generated by crossing Cd200^fl/fl mice with Krt14Cre transgenic mice [36 (link)] (B6N.Cg-Tg(KRT14-cre)1Amc/J; The Jackson Laboratory) to generate Krt14Cre;Cd200^fl/fl (EpiKO) mice (Supplemental Figure 1A). Wild-type animals used were FVB/N (Taconic Biosciences) and C57Bl/6 (Jackson Laboratories). Nu/J immunocompromised mice (The Jackson Laboratory) were chosen for orthotopic studies as they harbor the same MHC H2 haplotype, H-2Kq, as the FVB/N mouse strain. All animals were housed under pathogen-free conditions and received standard rodent chow and water ad libitum according the Institute of Comparative Medicine guidelines. All experiments involving mice were conducted under Columbia University IACUC-approved protocols.

Khan I.Z., Del Guzzo C.A., Shao A., Cho J., Du R., Cohen A.O, & Owens D.M. (2021). The CD200-CD200R axis promotes squamous cell carcinoma metastasis via regulation of cathepsin K. Cancer research, 81(19), 5021-5032.

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