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B ap15 hy 13989

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B-AP15 (HY-13989) is a small molecule compound that functions as a selective inhibitor of the deubiquitinating enzymes USP14 and UCHL5. It exhibits a potent and specific inhibitory activity towards these two deubiquitinating enzymes.

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Lab products found in correlation

Ab75817, by Abcam (2 mentions) Ab75851, by Abcam (2 mentions) Ab166917, by Abcam (2 mentions) Ab184177, by Abcam (2 mentions) Anti gapdh ap0063, by Bioworld Technology (2 mentions) Anti k48 linkage specific polyubiquitin, by Cell Signaling Technology (2 mentions) Anti usp2 ab168945, by Abcam (2 mentions) Ab124728, by Abcam (2 mentions) Ab67035, by Abcam (2 mentions) α1 antitrypsin ab207303, by Abcam (2 mentions) Anti rbx1 ab133565, by Abcam (2 mentions) Anti rbx2 ab181986, by Abcam (2 mentions) Anti antithrombin, by Abcam (2 mentions) Af1267, by Novus Biologicals (2 mentions) Anti gfp ap0675m and bs6507, by Bioworld Technology (2 mentions) Anti ubiquitin sc 8017 and horseradish peroxidase hrp conjugated secondary antibodies sc 2054 and sc 2055, by Santa Cruz Biotechnology (2 mentions)

2 protocols using b ap15 hy 13989

1

Comprehensive Ubiquitin System Protein Analysis

Check if the same lab product or an alternative is used in the 5 most similar protocols
Anti-USP2 (ab168945), anti-NAE1 (ab187142), anti-UBE2M (ab109507), anti-UBA3 (ab124728), anti-Cullin 1 (ab75817), anti-Cullin 2 (ab166917), anti-Cullin 3 (ab75851), anti-Cullin 4A (ab67035), anti-Cullin 4B (ab67035), anti-Cullin 5 (ab184177), anti-α1 antitrypsin (ab207303), anti-RBX1 (ab133565), and anti-RBX2 (ab181986) were obtained from Abcam (Cambridge, UK). Anti-antithrombin was purchased from Abcam (ab126598) and Novus biologicals (AF1267). Mouse IgG (magnetic bead conjugate) (5873), rabbit (DA1E) mAb IgG XP isotype control (magnetic bead conjugate) (8726), anti-HA (3724), anti-FLAG (14793), anti-USP2 (8036), and anti-K48-linkage–specific polyubiquitin (8081) were purchased from Cell Signaling Technology (Beverly, MA, USA). Anti-GFP (AP0675M and BS6507) and anti-GAPDH (AP0063) were obtained from Bioworld Technology (Louis Park, MN, USA). Anti-ubiquitin (sc-8017) and horseradish peroxidase (HRP)-conjugated secondary antibodies (sc-2054 and sc-2055) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA). ML364 (HY-100900), LDN-57444 (HY-18637), SJB-043 (HY-15757), P5091 (HY-15667), DUBs-IN-2 (HY-50737A), PR619 (HY-13814), MLN4924 (HY-70062), bortezomib (HY-10227), and b-AP15 (HY-13989) were purchased from MedChemExpress (Monmouth Junction, NJ, USA).
Xu D., Wu J., Chen J., Jiang L., Chen J., Bao W., Chen X., Yang Q., Zhang X., Yao L., Su H, & Liu J. (2021). Cullin 2-RBX1 E3 ligase and USP2 regulate antithrombin ubiquitination and stability. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 35(8), e21800.
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2

Comprehensive Ubiquitin System Protein Analysis

Check if the same lab product or an alternative is used in the 5 most similar protocols
Anti-USP2 (ab168945), anti-NAE1 (ab187142), anti-UBE2M (ab109507), anti-UBA3 (ab124728), anti-Cullin 1 (ab75817), anti-Cullin 2 (ab166917), anti-Cullin 3 (ab75851), anti-Cullin 4A (ab67035), anti-Cullin 4B (ab67035), anti-Cullin 5 (ab184177), anti-α1 antitrypsin (ab207303), anti-RBX1 (ab133565), and anti-RBX2 (ab181986) were obtained from Abcam (Cambridge, UK). Anti-antithrombin was purchased from Abcam (ab126598) and Novus biologicals (AF1267). Mouse IgG (magnetic bead conjugate) (5873), rabbit (DA1E) mAb IgG XP isotype control (magnetic bead conjugate) (8726), anti-HA (3724), anti-FLAG (14793), anti-USP2 (8036), and anti-K48-linkage–specific polyubiquitin (8081) were purchased from Cell Signaling Technology (Beverly, MA, USA). Anti-GFP (AP0675M and BS6507) and anti-GAPDH (AP0063) were obtained from Bioworld Technology (Louis Park, MN, USA). Anti-ubiquitin (sc-8017) and horseradish peroxidase (HRP)-conjugated secondary antibodies (sc-2054 and sc-2055) were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA). ML364 (HY-100900), LDN-57444 (HY-18637), SJB-043 (HY-15757), P5091 (HY-15667), DUBs-IN-2 (HY-50737A), PR619 (HY-13814), MLN4924 (HY-70062), bortezomib (HY-10227), and b-AP15 (HY-13989) were purchased from MedChemExpress (Monmouth Junction, NJ, USA).
Xu D., Wu J., Chen J., Jiang L., Chen J., Bao W., Chen X., Yang Q., Zhang X., Yao L., Su H, & Liu J. (2021). Cullin 2-RBX1 E3 ligase and USP2 regulate antithrombin ubiquitination and stability. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 35(8), e21800.
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