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256 slice ct

Manufactured by Philips
Sourced in Japan

The Philips 256 Slice CT is a high-resolution computed tomography (CT) imaging system. It features a 256-slice detector configuration, enabling rapid image acquisition and detailed visualization of anatomical structures.

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6 protocols using 256 slice ct

1

CT Imaging of iBead Phantoms

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Clinical CT imaging and analysis of iBead containing phantoms was performed on a 256 Slice CT (Philips, Andover, MA) with the following settings to determine the attenuation: 465 mAs tube current, 80 keV tube voltage, 1 mm slice thickness, 0.5mm overlap. The average attenuation of an 80 mm2 rectangular region in the middle slice of a given phantom was measured using OsiriX Software (V.5.02 64-bit).
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2

Comprehensive in vitro characterization of radiopaque beads

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The full description of in vitro characterization may be found in supplemental information. Briefly, bead size and appearance was evaluated with light microscopy. Iodine content was determined with elemental analysis (MEDAC Ltd, UK). Doxorubicin and Lipiodol elution was measured in a Caleva USP2 dissolution bath monitored by a Cary 50 UV-visible spectrophotometer (Varian, Australia) and elemental analysis, respectively. Attenuation of homogeneous radiopaque bead phantoms was measured with 256 Slice CT (Philips Healthcare, Cleveland, OH) to relate radiopaque bead concentration to attenuation. MicroCT imaging and analysis of phantoms was performed with a SkyScan 1172 high-resolution micro-CT (Skyscan, Konitch, BE) to evaluate the radiopacity of each individual bead, as well as, intra-bead distribution of iodine/Lipiodol.
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3

Abdominal CT Imaging Protocol for Surgery

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All patients underwent an abdominal contrast-enhanced CT scan preoperatively. Contrast-enhanced CT scan was performed on three CT scanners including a 16-slice CT (Toshiba Medical Systems, Japan), a 64-, and a 256-slice CT (Philips Healthcare, Netherlands). CT scans used the same CT scanning parameters: tube voltage of 120 kVp, tube current of 125 to 300 mAs, pitch of 0.6 to 1.25 mm, slice thickness of 3 to 5 mm, and reconstruction interval of 3 to 5 mm.
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4

Hepatic Artery Embolization in Vx2 Tumors

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All animal studies were conducted under an animal use protocol approved by the Institutional Animal Care and Use Committee. Additional details may be found in supplemental information. Briefly, Vx2 tumors were propagated as described by Ranjan et al. [17 (link)]. Femoral access and catheter placement in the proper hepatic artery was conducted with a 3F sheath (Cook, Bloomington, IN) and a 2.4 Fr microcatheter (Terumo, Somerset, NJ) under fluoroscopic guidance. Routine fluoroscopy was conducted using the 9900 Elite Digital Mobile Super C-arm (GE Healthcare/OEC Medical Systems, Inc., Waukesha, WI). Radiopaque beads (100–300 μm) were mixed 1:20 in saline/Isovue 300 contrast and delivered under fluoroscopic monitoring at a rate of approximately 1 ml/min (including agitation time) until stasis in the main hepatic artery was determined angiographically.
Harvested liver tissue was imaged on 256 slice CT (Philips Healthcare). To resolve individual radiopaque beads within tissue an Inveon microCT (Siemens Preclinical Solutions, Knoxville, TN) was used.
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5

Abdominal CT Enhancement Imaging Protocols

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Abdominal CT enhancement examinations were performed on all patients within 1 month before the operation. Enhanced CT scan in the first hospital was performed using three CT scanners, including a 64-slice CT, a 256-slice CT (Philips Healthcare), and a 16-slice CT (Toshiba Medical System). Contrast-enhanced CT scan in the second hospital was performed using two CT scanners, including a 40-slice CT (Siemens AG) and a 320-slice CT (Toshiba Medical Systems). CT scan parameters of the two hospitals were uniform and included the following: tube voltage at 120 kVp, tube current ranging from 125 to 300 mAs, pitch ranging from 0.6 to 1.25 mm, slice thickness ranging from 3 to 5 mm, and reconstruction interval from 3 to 5 mm. A high-pressure syringe was used to administer the non-ionic contrast agent Ultravist (Bayer Schering Pharma) (1.5 ml/kg) at a rate of 3.0 ml/s. CT scans of the arterial phase and portal vein phase were performed at 25 to 35 s and 55 to 75 s after administration of the non-ionic contrast agent.
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6

Quantifying Contrast Agent Distribution in Agarose Phantoms

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The distribution of conjugated iodine contrast agent within the bead agarose phantoms was imaged on a clinical 256 Slice CT (Philips, Andover, MA) to determine the overall attenuation. The following settings: 465 mAs tube current, 120 kV tube voltage, 2 mm thickness, 0.5 mm overlap were used. The average attenuation of a 92.4 mm2 cylindrical region along the phantom was selected and measured in grey scale using OsiriX (V.5.02 64-bit) and later converted into HU from a two point regression curve for water and air. Dox content was calculated based on the total bead volume in the phantom and amount of Dox-loaded (37.5 mg/mL).
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