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2 protocols using diethylene glycol monoethyl ether

1

Transdermal Delivery of Licochalcone A and Glabridin

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Licochalcone A (LicA, purity >98%) and glabridin (Gla, purity >98%) were obtained from Nanjing Spring & Autumn Biological Engineering Co., Ltd. (Nanjing, China). Poly(acrylic acid) (commercial names: Carbomer 940 (CP)), isopropyl myristate (IPM, purity: 98%), diethylene glycol monoethyl ether (commercial names: Transcutol® P (TP), purity: 99%), and 1-methyl-2-pyrrolidinone (NMP, purity >99%) were purchased from Shanghai Macklin Biochemical Co., Ltd. (Shanghai, China). propylene glycol monocaprylate (commercial names: CapryolTM 90 (CP 90)) and polyglyceryl-3dioleate (commercial names: Plurol® Oleique CC 497 (POCC)) were supplied by Gattefossé (Lyon, France). Polyoxyethylenesorbitan monooleate (commercial names: Span 80 (SP)) and propylene glycol (PG, purity > 99%) were purchased from Damao Chemical Reagent Factory (Tianjin, China). Polyethylene glycol 400 (PEG 400) and cellophane membranes were purchased from Beijing Solarbio Technology Co., Ltd., Beijing, China. All other reagents were analytical grade.
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2

Hesperetin Formulation Development and Characterization

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Hesperetin (purity grade>98%) was purchased from Tianbao Biotechnology Co., Ltd (Xi'an, China). Triacetin was purchased from usolf Chemical Technology Co., Ltd (Shandong, China). Medium chain triglycerides was obtained from yuanye Bio-Technology Co., Ltd (Shanghai, China). Propylene glycol, ethanol were purchased from Chengdu Kelong Chemical Corporation (Sichuan, China). Diethylene glycol monoethyl ether, isopropyl myristate, ethyl oleate, castor oil were purchased from Shanghai Macklin Biochemical Co., Ltd (Shanghai, China). Sodium carboxymethyl cellulose was purchased from Titan Scientific Co., Ltd (Shanghai, China). Cycloheximide(purity grade≥94.0%) was obtained from BoMei Biotechnology Co.Ltd (Hefei, China). Formic acid, acetonitrile and methanol were HPLC grade and purchased from Kermel Reagent (Tianjin, China).
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