The rats of Antibiotic+Statin group were i.g. administrated with Rosuvastatin (10 mg/kg body weight/day; AstraZeneca China, J20120006) dissolved in water for 4 weeks after 8 days administration of Ceftriaxone sodium. The rats from Statin group were i.g. administrated with Rosuvastatin (10 mg/kg body weight/day; AstraZeneca China, J20120006) for 4 weeks. The rats of control Water group were i.g. given same volume of water for 4 weeks.
Rosuvastatin
Manufactured by AstraZeneca
Sourced in China, United Kingdom
Rosuvastatin is a pharmaceutical compound used in the production and analysis of various lab equipment. It is a synthetic statin drug that functions as an inhibitor of the enzyme HMG-CoA reductase, a key enzyme involved in the biosynthesis of cholesterol. Rosuvastatin is commonly utilized in research and development processes within the pharmaceutical industry.
Automatically generated - may contain errors
Lab products found in correlation
Atorvastatin, by Merck Group (2 mentions)
Valsartan, by Merck Group (1 mentions)
Losartan, by Merck Group (1 mentions)
Ranitidine, by Merck Group (1 mentions)
Enalapril, by Merck Group (1 mentions)
Clonazepam, by Merck Group (1 mentions)
Clopidogrel, by Merck Group (1 mentions)
Chlorpheniramine, by Merck Group (1 mentions)
Atenolol, by Merck Group (1 mentions)
Loratadine, by Merck Group (1 mentions)
Bromazepam, by Merck Group (1 mentions)
Acetaminophen, by Merck Group (1 mentions)
Diazepam, by Merck Group (1 mentions)
Cyproterone, by Merck Group (1 mentions)
Crestor, by AstraZeneca (1 mentions)
Lc ms grade formic acid, by Merck Group (1 mentions)
Methanol, by Merck Group (1 mentions)
Ammonium acetate, by Merck Group (1 mentions)
Caffeine, by Merck Group (1 mentions)
Acetonitrile, by Merck Group (1 mentions)
9 protocols using rosuvastatin
1
Rosuvastatin and Ceftriaxone Experiment
2
Pharmaceutical Solutions Preparation Protocol
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
All drugs were purchased from Sigma-Aldrich Co. (USA), except rosuvastatin, which was a gift from Laboratories Astra-Zeneca, SA de CV (Mexico). rosuvastatin, L-NAME, 4-AP, TEA, glibenclamide, clotrimazole, and cycloheximide were dissolved in distilled water. Solutions of 10−5 M ODQ, 10−4 M KT 5823, 10−5 M apamin plus 10−5 M charybdotoxin, and 10−3 M indomethacin were prepared using 1.39 M dimethyl sulfoxide, 1.01 M ethyl acetate, 1.73 M acetic acid, and 9.4×10−3 M sodium bicarbonate, respectively. Fresh solutions were made for each experiment.
3
Analytical Standards Acquisition for LC-MS
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
Chemicals and analytical reagents such as nitric acid and sulphuric acid were purchased from Merck (Darmstadt, Germany). Grade solvents used in HPLC and LC-MS, such as acetonitrile, methanol and isopropanol, were acquired from Sigma-Aldrich (Massachusetts, USA). Mobile phase additives, namely LC-MS grade formic acid and ammonium acetate, were acquired from Sigma-Aldrich and Merck, respectively. Analytical standards of acetaminophen, atenolol, bromazepam, caffeine, carbamazepine, cyproterone, clonazepam, clopidogrel, diclofenac, enalapril, loratadine, losartan, midazolam orphenadrine, propranolol, sildena l, atorvastatin, ranitidine, diazepam, chlorpheniramine and valsartan were acquired from Sigma-Aldrich. Cocaine and benzoylecgonine were acquired from Cerillant (Texas, USA). The other pharmaceuticals were bought in several suppliers: citalopram (Alcytam®: Torrent, Brazil), chlortalidone (Higroton®: Novartis, Swiss), rosuvastatin (Crestor®: AstraZeneca, UK) and generic paroxetine medication (Medley, Brazil).
4
Huh7 Cells Statin Treatment Protocol
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
Human HCC cell line Huh7 was obtained from American Type Culture Collection (ATCC; USA) and maintained in Dulbecco’s modified Eagle’s medium (DMEM) (Gibco; USA) containing 10% fetal bovine serum (FBS), 1% non-essential amino acid, 1% L-glutamine, and 1% penicillin-streptomycin (Gibco) in a humidified incubator (Thermo Fisher; USA) at 37 °C under 5% CO2 atmosphere. For transfection, cells were plated on cell culture dishes at 70% confluence, and transfected on the following day with FuGENE HD transfection reagent (Roche; Switzerland). For treatment with statins, the HMG-CoA-reductase inhibitors fluvastatin (Sigma-Aldrich; USA), simvastatin (Sigma-Aldrich), atorvastatin (Sigma-Aldrich), rosuvastatin (Astra Zeneca; London, UK), lovastatin (Sigma-Aldrich), and pravastatin (Sigma-Aldrich) were dissolved in DMSO, and cells were treated with each of the six types of statin (final concentration 5 or 25 μM by dilution in medium) for three or 9 days and subjected to luciferase reporter assay, enzyme-linked immunosorbent assay (ELISA), and Western blotting. DMSO alone was used as negative control.
5
Chemical Compound Preparation Protocol
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
All drugs except rosuvastatin were purchased from Sigma-Aldrich (St Louis, MO, USA). rosuvastatin was a gift from AstraZeneca (Mexico City, Mexico). All compounds were dissolved in distilled water. Fresh solutions were prepared for each experiment.
6
Rosuvastatin and Schisantherin A Formulations
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
The calcium tablet of rosuvastatin (lot 1902A44) was supplied by AstraZeneca Pharmaceutical Co., Ltd. WZ (lot180301), which contains 11.25 mg of Schisantherin A per capsule, was purchased from Sichuan Hezheng Pharmaceutical Co., Ltd. (China). rosuvastatin calcium gavage solution was prepared by dissolving the rosuvastatin calcium tablet powder in suspension with 0.5% sodium carboxymethylcellulose solution (25 mg/25mL) by ultrasound. The WZ gavage solution was prepared by dissolving the WZ contents after removing the capsule shell into suspension with 0.5% sodium carboxymethylcellulose solution (375.0 mg/25 mL) by ultrasound.
7
Rosuvastatin Mitigates Adriamycin-Induced Cardiotoxicity
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
The rats were randomized into the following groups (n=10/group): i) Control group, rats administered with 0.9% saline solution without ADR at 1 mg/kg/day for 14 days via intraperitoneal injection and with 0.9% saline without Rosuvastatin at a dosage of 1 mg/kg/day for 6 weeks by gavage administration; ii) ADR group, rats injected with equal volumes of ADR solution (ADR dissolved in 0.9% saline solution, 10 mg/ml) for 2 weeks plus administration of equal volumes of 0.9% saline solution without Rosuvastatin; iii) ADR+Rosuvastatin group, rats administered with equal volumes of ADR for 2 weeks and Rosuvastatin (1 mg/kg/day) (22 (link)) solution for 6 weeks (Rosuvastatin was dissolved in 0.9% saline solution, 10 mg/ml). All rats received the drug at 10 a.m. and the intraperitoneal injection at 9 a.m. (1 h prior to gavage). ADR was purchased from Haizheng Chemical Co., Ltd. (Zhejiang, China). Rosuvastatin was provided by AstraZeneca (London, UK). All examinations and sample collection (echocardiography, blood collection, and myocardial tissue collection) were performed at 12 weeks.
8
Rosuvastatin Reduces Aortic Aneurysm in ApoE-/- Mice
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
Rosuvastatin (AstraZeneca, Wilmington, DE) was dissolved in 30-μL polysorbate 80. Normal saline was added to yield 100 mg/kg stock solutions. The saline vehicle was prepared similarly without the addition of Rosuvastatin. The dose of Rosuvastatin was chosen to elicit pleiotropic effects in the absence of lipid lowering as previously reported [23 (link),24 (link)]. ApoE-/- mice undergoing Ang II infusion were randomized and treated with daily intraperitoneal (IP) injections of saline vehicle (n = 8) or Rosuvastatin (n = 10) for 35 days, beginning 21 days prior to pump implantation. After this period of time, all animals were sacrificed and post-mortem measurements of suprarenal (SR) and IR aortic diameters were performed. AAA severity was classified as follows: Type 1, SR/IR ratio < 2; Type 2, SR/IR ratio > 2; Type 3, presence of aortic dissection. Measurements of serum total cholesterol, triglycerides, high-density lipoprotein (HDL), and low-density lipoprotein (LDL) were performed using enzymatic assay kits.
9
Acute Coronary Syndrome Treatment
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
Patients admitted to the hospital with a diagnosis of ACS (including STEMI, NSTEMI, UA, and CAD) are treated with antibodies, anticoagulants, enhanced statins, beta receptor antagonists, ACEI, or ARB. Medications are started approximately within 2–3 h after stent implantation. The drugs used were Brilinta (AstraZeneca Pharmaceuticals, China), Metoprolol (AstraZeneca Pharmaceuticals, China), Clopidogrel (Shenzhen Xinitai Pharmaceuticals, China), Simvastatin (Hangzhou Merck), Rosuvastatin (AstraZeneca Pharmaceuticals, China), Valsartan, Olmesartan, Benazepril (Changzhou Siyao Pharmaceuticals, China).
About PubCompare
Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.
We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.
However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.
Ready to get started?
Sign up for free.
Registration takes 20 seconds.
Available from any computer
No download required
Revolutionizing how scientists
search and build protocols!