Phenol

Manufactured by Novo Nordisk

Sourced in Denmark

Phenol is a chemical compound commonly used in laboratory settings. It is a colorless to light-pink crystalline solid with a distinctive odor. Phenol serves as a core ingredient in various analytical and experimental procedures, providing essential functions for researchers and scientists.

Automatically generated - may contain errors

Lab products found in correlation

Sb202190, by Bio-Techne (1 mentions) Su3327, by Bio-Techne (1 mentions) Apidra, by Sanofi (1 mentions) Insuman infusat, by Sanofi (1 mentions) Recombinant human insulin, by Roche (1 mentions) M cresol, by Merck Group (1 mentions) Novorapid, by Novo Nordisk (1 mentions) Humalog, by Eli Lilly (1 mentions) Zinc chloride, by Novo Nordisk (1 mentions) Glycerol, by Novo Nordisk (1 mentions) Metacresol, by Novo Nordisk (1 mentions) Strat m membrane, by Merck Group (1 mentions) Sepineo p 600, by Seppic (1 mentions)

2 protocols using phenol

Insulin Formulations and Kinase Inhibitors

Check if the same lab product or an alternative is used in the 5 most similar protocols

phenol (CAS No.108-95-2) and m-cresol (CAS No. 108-39-4) were obtained from Sigma–Aldrich. Jun N-terminal kinase (JNK) inhibitor SU3327 (10–20 μM in dimethyl sulfoxide (DMSO)) and p38 Inhibitor SB202190 (1–2 μM in DMSO) were from Tocris Bioscience.
The following formulations of insulin or insulin analogs were used, each at 100 I.U./ml: Apidra (3.15 mg/ml m-cresol, Sanofi-Aventis), Insuman Infusat (2.7 mg/ml phenol, Sanofi-Aventis), Humalog (3.15 mg/ml m-cresol, Eli Lilly), NovoRapid (1.72 mg/ml m-cresol and 1.5 mg/ml phenol, Novo Nordisk). Recombinant human insulin (Roche Diagnostics GmbH) was dissolved in phosphate buffer at 3 mg/ml (equivalent to 100 U/ml).

Weber C., Kammerer D., Streit B, & Licht A.H. (2014). Phenolic excipients of insulin formulations induce cell death, pro-inflammatory signaling and MCP-1 release. Toxicology Reports, 2, 194-202.

+ Open protocol

+ Expand

Transdermal Insulin Delivery Optimization

Check if the same lab product or an alternative is used in the 5 most similar protocols

Insulatard Penfil (INS) 100 IU/mL (human insulin, isophane, long-acting; excipients: zinc chloride, glycerol, metacresol, phenol, disodium phosphate dihydrate, sodium hydroxide, hydrochloric acid, protamine sulphate, water for injection) was purchased from Novo Nordisk (Bagsværd, Denmark). Sepineo™ P 600 and Sepineo™ PHD 100 were donated by Seppic (Paris, France). glycerol 85% was purchased from Galfarm (Krakow, Poland). Phosphate-buffered saline (PBS) pH = 7.4 was purchased from Sigma-Aldrich Co. (St. Louis, MO, USA). All chemicals used in the study were of analytical grade. The Strat-M^® membrane was purchased from Merck Millipore (Burlington, MA, USA).

Ostróżka-Cieślik A., Wilczyński S, & Dolińska B. (2023). Hydrogel Formulations for Topical Insulin Application: Preparation, Characterization and In Vitro Permeation across the Strat-M® Membrane. Polymers, 15(17), 3639.

+ Open protocol

+ Expand

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Revolutionizing how scientists
search and build protocols!