A commercially available product of edaravone for IV administration was not used in these studies. The formulation of the interventions, including the newly developed oral solution and suspension of edaravone, used in study 1 and study 2 are summarized in Table 1 . In study 1, the edaravone oral solution and suspension were used, including a formulation containing xanthan gum to modify the viscosity of the suspension. In cohort 1 of study 2, the same oral suspension as in study 1, but without xanthan gum, was used, while in cohort 2 an oral suspension with various ingredients was used. In addition to edaravone, commercially available typical substrates, rosuvastatin (Crestor tablets, AstraZeneca), sildenafil (Viagra tablets, Pfizer), and furosemide (Lasix tablets, Aventis Pharma) were used in cohort 1 of study 2.
Crestor tablets
Manufactured by AstraZeneca
Crestor tablets are a pharmaceutical product manufactured by AstraZeneca. The core function of Crestor tablets is to help lower cholesterol levels in the blood.
Automatically generated - may contain errors
2 protocols using crestor tablets
1
Evaluation of Edaravone Oral Formulations
2
Rosuvastatin Calcium Formulation Development
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Rosuvastatin calcium was generously supplied by Global Napi Pharmaceutical Company, Cairo, Egypt (Batch number: RV0140614). Cetyl alcohol (CA), Tween 80 (T80), mannitol, Aerosil 200 (Fumed silica), and polyethylene glycol 400 (PEG) were purchased from Sigma–Aldrich, St. Louis, MI, USA. Crestor® tablets, AstraZeneca, Giza, Egypt (Batch number: 170509) were purchased from the Egyptian market. Eudragit L100 was supplied by Rohm GmbH, Darmstadt, Germany.
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