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Foxm1 small interfering rna

Manufactured by Merck Group
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Sourced in United States

FOXM1 small interfering RNA is a laboratory reagent designed to target and downregulate the expression of the FOXM1 gene. It is a double-stranded RNA molecule that can induce post-transcriptional gene silencing through the RNA interference (RNAi) pathway. The core function of this product is to provide researchers with a tool to study the role of FOXM1 in various biological processes.

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Lab products found in correlation

Lipofectamine rnaimax, by Thermo Fisher Scientific (4 mentions)

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FOXM1

2 protocols using foxm1 small interfering rna

1

Silencing FOXM1 and FOXO3 in HDFs and Breast Cancer Cells

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HDFs were transfected with 45 nM siRNA Universal Negative Control #1 (Sigma-Aldrich, MO, USA), 45 nM FOXM1 small interfering RNA (SASI_Hs01_00243977, Sigma-Aldrich, MO, USA), or 45 nM FOXO3 small interfering RNA (SASI_HS01_00119127, Sigma-Aldrich, MO, USA) using Lipofectamine RNAiMAX (Thermo Fisher Scientific, CA, USA) according to manufacturer’s instructions. MCF-7 and MDA-MB-231 were transfected with 20 nM siRNA. Cells were analyzed 72 h post transfection, and depletion efficiency was validated by qPCR.
Vaz S., Ferreira F.J., Macedo J.C., Leor G., Ben-David U., Bessa J, & Logarinho E. (2021). FOXM1 repression increases mitotic death upon antimitotic chemotherapy through BMF upregulation. Cell Death & Disease, 12(6), 542.
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2

Depletion of FoxM1 in Cells

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Cells were transfected 1 h after plating, with 45 nM FoxM1 small interfering RNA (SASI_Hs01_00243977 from Sigma-Aldrich, MO, USA) using Lipofectamine RNAiMAX (Thermo Scientific) according to manufacturer’s instructions. Phenotypes were analyzed and quantified 72 h post transfection, and depletion efficiency monitored by western blotting.
Macedo J.C., Vaz S., Bakker B., Ribeiro R., Bakker P.L., Escandell J.M., Ferreira M.G., Medema R., Foijer F, & Logarinho E. (2018). FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence. Nature Communications, 9, 2834.
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