1 1 dioctadecyl 3 3 3 3 tetramethylindotricarbocyanine iodide

Cepharanthine was purchased from Saen Chemical Technology Co., Ltd. (Shanghai, China). Labrafac lipophile WL 1349 was supplied by Gattefosse (Lyon, France). Soy Lecithin and coumarin-6(Cou6) were purchased from Yuanye Bio-Technology Co., Ltd. (Shanghai, China). Poloxamer188 was supplied by BASF (Ludwigshafen, Germany). 1,1′-Dioctadecyl-3,3,3′,3′-tetramethylindotricarbocyanine iodide (DiR) was purchased from Dalian Meilun Biotechnology Co., Ltd. (Dalian, China). Hoechst 33258 and all kinds of enzyme-linked immunosorbent assay (ELISA) kits were purchased from Solarbio (Beijing, China). 1,1′-Dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate (DiI) and 4′,6-diamidino-2-phenylindole (DAPI) were purchased from Beyotime Institute of Biotechnology Co., Ltd. (Jiangsu, China). 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) was purchased from Sigma-Aldrich (Louis, USA).

PTX, dithiothreitol (DTT), 1,1'-dioctadecyl-3,3,3',3'-tetramethylindotricarbocyanine iodide (DiR), and 2-(4-Amidinophenyl)-6-indolecarbamidine dihydrochloride (DAPI) were supplied from Meilun Biotech (Dalian, China). Perfluorooctanol, octanol, coumarin-6, 1-Ethyl-3-(3-dimethyllaminopropyl) carbodiimide hydrochloride (EDCI), 4-dimethylaminopyrideine (DMAP) and hydrogen peroxide (H₂O₂) were all bought from Aladdin Biochemical Technology Co. Ltd. (Shanghai, China). 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-methyl (polyethylene glycol)-2000 (DSPE-PEG_2k) was provided from Shanghai Advanced Vehicle Technology Co. Ltd. (Shanghai, China). Cell culture reagents and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) were derived from Gibco (Beijing, China). Calcein-AM/PI double stain kit, Annexin V-FITC/PI apoptosis assay kit and Microtubule Tracker Red were purchased from Beijing Solarbio Science & Technology Co., Ltd. TUNEL apoptosis detection kit and Ki67 cell proliferation kit were supplied from Service biotech Co., Ltd. (China). Hoechst 33342 was provided by BD Biosciences (USA). The other reagents used in this paper were of analytical.