Sham-operated animals underwent a similar procedure, with the exception of arterial occlusion. The ischemia reperfusion (IR) control group received DMSO (Amresco, USA, 1 µL/kg, iv) administration immediately after ischemia (n=6). Two different doses of salvinorin A (Sigma, USA, 10 and 20 µg/kg, iv) were administered with the onset of reperfusion (n=6). The 5th, 6th, and 7th groups received salvinorin A (20 µg/kg, iv) and LY294002 (Cayman Chemical, USA, inhibitor of PI3K, 10 µM), L-NAME (Cayman Chemical, inhibitor of NOS, 10 μM) or norbinaltorphimine (norBIN, Sigma, antagonist of KOR, 1 μM), injected topically through cranial window, after ischemia (n=6) as described in previous studies (19 (link)–21 (link)).
Salvinorin a
Manufactured by Cayman Chemical
Sourced in United States
Salvinorin A is a naturally occurring compound found in the leaves of the plant Salvia divinorum. It is a potent and selective kappa opioid receptor agonist, which means it binds to and activates a specific type of opioid receptor in the body. Salvinorin A is used for research purposes to study the effects of kappa opioid receptor activation on various biological processes.
Automatically generated - may contain errors
2 protocols using salvinorin a
1
Salvinorin A Neuroprotection in Ischemia-Reperfusion
2
Salvinorin A Intraperitoneal Injection
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Salvinorin A (Cayman Chemicals, Ann Arbor, MI, USA) was suspended in a 1% solution of Tween 80 and injected intraperitoneally (i.p.) 30 min before each test. The pretreatment time was based on literature data [31 (link),43 (link),44 (link)]. Control animals received vehicle only. The injection volume was 10 mL/kg.
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