After pleural injury, computer randomization was used to assign the animal to one of four interventions: 1) a novel pectin based bioadhesive, 2) fibrin sealant patches (EVARREST™, Ethicon, Somerville, NJ), 3) fibrin sealant bio-adhesive glue (EVICEL™ Fibrin Sealant [Human], Ethicon, Somerville, NJ), or 4) surgically stapled wedge resection of the effected lung. The standardized parenchymal resection removed only the lacerated tissue. Manufacturer guidelines for use were strictly followed during use of the commercially available products. Once interventions were applied, gross evidence of air leak seal and changes in tidal volume were observed and recorded. Following the initial assessment, defined as early success, a 20Fr chest tube (Cardinal Health, Dublin, OH) was placed in the left hemithorax and the thoracotomy was closed using running #0 silk suture (Ethicon, Somerville, NJ) sutures. Animals were observed and ventilated for at least 30 minutes to detect the subsequent development of a late air leak; absence of an air leak was defined as late success. Chest tubes were placed on water seal using an Atrium Oasis™ chest drainage system (Getinge AB, Wayne, NJ). The water seal chamber was used for semi-quantitative air leak detection and trending.
Evicel fibrin sealant human
Manufactured by Johnson & Johnson
Sourced in United States
EVICEL™ Fibrin Sealant is a sterile, non-pyrogenic, biodegradable, and colorless solution containing human-derived fibrinogen and thrombin. It is intended for use as a tissue sealant to control bleeding and to promote tissue healing.
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Lab products found in correlation
3 protocols using evicel fibrin sealant human
1
Comparative Evaluation of Lung Sealants
2
Laparoscopic Splenectomy Technique
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The spleen is then released from its remaining retroperitoneal attachments. The specimen is removed from a Pfannenstiel incision (approximately 6 cm) in an impermeable extraction bag (Endocatch, Ethicon EndoSurgery) that was passed through a 15-mm port. Care is taken not to crush the specimen in order to compromise pathological assessment. The peritoneum is closed with one vicryl and the fascia with a one PDS loop, and this is then visualised laparoscopically to ensure optimal closure. The resection site is inspected and haemostasis ensured. The stump is only secured with interrupted PDS 3/0 sutures if there are areas of parenchymal fractures or ongoing bleeding. A combination of absorbable haemostatic material (SURGICEL SNoW, Ethicon Endosurgery) and haemostatic glue (EVICEL Fibrin Sealant (Human), Ethicon Endosurgery) can be applied. A 20F Wallace drain is placed adjacent to the resection line of the pancreas with a loop in the splenic bed with 2–3 additional side holes at this site and secured. The fascial defects on all ports larger than 5 mm are closed using an absorbable multifilament suture and skin closed using absorbable monofilament.
3
Cardiac Cell Transplantation for MI
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MI was induced in nude (NU-Foxn1nu) mice (Charles River Laboratories, Wilmington, MA, USA) by permanent ligation of the left anterior descending coronary artery (LAD). Then 3.6 mm3 of SIS-ECM (depth 3 mm, width 3 mm, height 0.4 mm) was seeded with 3.6 × 105 Isl1+ CPCs and incubated in DM2 medium without growth factors for 7 days before transplantation. Fibrin gel (EVICEL® Fibrin Sealant (Human); Ethicon, Somerville, MA, USA) was applied to the edges of SIS-ECM patches containing Isl1+ CPC-differentiated cardiac cells with DM2 medium for attachment of the patches to the infarcted region of the left ventricle after induction of MI or to the left ventricle of normal hearts.
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