4 hydroxydiclofenac

Manufactured by Cayman Chemical

4-hydroxydiclofenac is a chemical compound used for research and laboratory applications. It is a metabolite of the pharmaceutical drug diclofenac. The product is supplied as a powder and is suitable for in vitro studies.

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Lab products found in correlation

S mephenytoin, by Cayman Chemical (4 mentions) 4 hydroxy s mephenytoin, by LGC (3 mentions) Phenacetin, by Merck Group (3 mentions) Coumarin, by Merck Group (3 mentions) Testosterone, by Cayman Chemical (3 mentions) Diclofenac sodium salt, by Cayman Chemical (3 mentions) Dextrorphan tartrate, by Cayman Chemical (3 mentions) 7 hydroxycoumarin, by Chem Service (3 mentions) 4 aminobenzoic acid, by Merck Group (2 mentions) Chlorzoxazone, by Merck Group (2 mentions) Dextromethorphan hydrobromide, by Merck Group (2 mentions) 6β hydroxytestosterone, by Merck Group (2 mentions) Paclitaxel, by Cayman Chemical (2 mentions) Benzydamine hydrochloride, by Merck Group (2 mentions) Kynuramine hydrobromide, by Santa Cruz Biotechnology (2 mentions) 6 hydroxychlorzoxazone, by LGC (2 mentions) 1 hydroxymidazolam, by LGC (2 mentions) 7 hydroxycoumarin β d glucuronide sodium salt, by Merck Group (2 mentions) 4 hydroxyquinoline, by Cayman Chemical (2 mentions) Benzydamine n oxide, by Santa Cruz Biotechnology (2 mentions)

4 protocols using 4 hydroxydiclofenac

High-Throughput Cytochrome P450 Profiling

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Acetaminophen, astemizole, bupropion, N‐acetyl‐p‐aminobenzoic acid, 4‐aminobenzoic acid, benzydamine hydrochloride, chlorzoxazone, coumarin, dextromethorphan hydrobromide, 7‐Ethoxy resorufin, 7‐Hydroxycoumarin β‐D‐glucuronide sodium salt, 7‐Hydroxycoumarin sulfate potassium salt, 6β‐hydroxy testosterone, irinotecan, midazolam, phenacetin, resorufin, SN38, and sulfamethazine were purchased from Sigma Aldrich. Dextrorphan tartrate, diclofenac sodium salt, 4‐hydroxydiclofenac, hydroxy bupropion, S‐mephenytoin, 4‐hydroxyquinoline, paclitaxel, and testosterone were purchased from Cayman Chemical. 7‐hydroxycoumarin was purchased from Chem Service. Benzydamine N‐oxide, kynuramine hydrobromide, and N‐acetyl sulfamethazine were obtained from Santa Cruz Biotechnology. Carbazeran, 4‐hydroxyCarbazeran, 6‐hydroxychlorzoxazone, 6α‐hydroxy paclitaxel, 1′‐hydroxymidazolam, and 4‐hydroxy‐S‐mephenytoin were obtained from Toronto Research Chemicals.

Li A.P., Ho M.D., Alam N., Mitchell W., Wong S., Yan Z., Kenny J.R, & E. C. A. Hop C. (2020). Inter‐individual and inter‐regional variations in enteric drug metabolizing enzyme activities: Results with cryopreserved human intestinal mucosal epithelia (CHIM) from the small intestines of 14 donors. Pharmacology Research & Perspectives, 8(5), e00645.

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Metabolism Assay for Pharmacological Compounds

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Astemizole, irinotecan hydrochloride, diclofenac sodium salt, 7-ethyl-10-hydroxycamptothecin (SN38), 4-hydroxydiclofenac, s-mephenytoin, and testosterone were purchased from Cayman Chemical (Ann Arbor, MI). 7-Hydroxy Coumarin was purchased from Chem Service (West Chester, Pennsylvania). 7-Hydroxy Coumarin sulfate potassium salt was obtained from Santa Cruz Biotechnology (Dallas, Texas). Coumarin, 6β-hydroxytestosterone, 7-Hydroxy Coumarin β-D-glucuronide sodium salt, (2S, 3S)-hydroxy were purchased from Sigma-Aldrich (St. Louis, MO). Midazolam, 1'-hydroxyMidazolam, O-desmethyl astemizole, and 4-hydroxy-s-mephenytoin were obtained from Toronto Research Chemicals (Toronto, Canada).

Li A.P., Amaral K, & Ho M.C. (2018). A Novel In vitro Experimental System for the Evaluation of Enteric Drug Metabolism: Cofactor-Supplemented Permeabilized Cryopreserved  Human Enterocytes (MetMax™ Cryopreserved Human Enterocytes). Drug Metabolism Letters, 12(2), 132-137.

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In Vitro Iohexol Elimination Assay

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Sterile sodium chloride (0.9% NaCl) and phosphate-buffered saline (PBS) were purchased from Baxter Healthcare Corporation (Deerfield, IL). Iohexol powder, paclitaxel, and gemcitabine were purchased from Toronto Research Chemicals Inc (Toronto, ON, Canada). Iohexol dosing solution was manufactured by GE Healthcare, (Shanghai, China) and obtained from the Hillman Cancer Research Pharmacy. All in vitro drug elimination incubations with iohexol were performed at 300 μg/mL which is at the upper range of the reported plasma concentrations [23 (link)]. [D₅]-iohexol (IS) was purchased from ALSACHIM (Graffenstaden, France). Carboplatin for dosing was manufactured by Ben Venue Labs Inc (Bedford, OH) and obtained from the Hillman Cancer Research Pharmacy. NADPH tetrasodium salt was purchased from Enzo Life Sciences (Farmingdale, NY). Carboplatin powder, MgCl₂, alamethicin, UDPGA sodium salt, phenacetin, dextromethorphan and midazolam methanolic solution was obtained from Sigma (St Louis, MO). [D₃]-dextrorphan and [D₄]-1-hydroxy midazolam were purchased from Sigma (St. Louis MO). 1-hydroxy midazolam, 4-hydroxy diclofenac, 4-hydroxy mephenytoin, dextrorphan tartrate, s-mephenytoin, SN-38, trifluoperazine, mycophenolic acid and naloxone were purchased from Cayman chemicals (Ann Arbor, MI).

Joshi A., Guo J., Holleran J.L., Kiesel B., Taylor S., Christner S., Parise R.A., Miller B.M., Ivy S.P., Chu E., Venkataramanan R, & Beumer J.H. (2020). EVALUATION OF THE PHARMACOKINETIC DRUG-DRUG INTERACTION POTENTIAL OF IOHEXOL, A RENAL FILTRATION MARKER. Cancer chemotherapy and pharmacology, 86(4), 535-545.

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Acquisition of Enzyme Substrates

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Dextrorphan tartrate, diclofenac sodium salt, 4-hydroxydiclofenac, S-mephenytoin, 4-hydroxyquinoline, paclitaxel, and testosterone were purchased from Cayman Chemical (Ann Arbor, MI). 7-Hydroxy coumarin was purchased from Chem Service (West Chester, PA). Benzydamine N-oxide, 7-Hydroxy coumarin sulfate potassium salt, kynuramine hydrobromide, and N-acetyl sulfamethazine were obtained from Santa Cruz Biotechnology (Dallas, TX). 4-Acetamidobenzoic acid, p-acetamidophenyl b-D-glucuronide sodium salt, 4-aminobenzoic acid, benzydamine hydrochloride, chlorzoxazone, coumarin, dextromethorphan hydrobromide, 6b-hydroxytestosterone, 7-Hydroxy coumarin b-D-glucuronide sodium salt, 7-ethoxycoumarin, paracetamol sulfate potassium, phenacetin, and sulfamethazine were purchased from Sigma-Aldrich (St. Louis, MO). Carbazeran, 4-hydroxyCarbazeran, 6-hydroxychlorzoxazone, 6a-hydroxypaclitaxel, acetaminophen glutathione disodium salt, midazolam, 19-hydroxymidazolam, and 4-hydroxy-S-mephenytoin were obtained from Toronto Research Chemicals (Toronto, ON, Canada). All other drug-metabolizing enzyme substrates were obtained from Sigma-Aldrich.

Li A.P., Alam N., Amaral K., Ho M.D., Loretz C., Mitchell W, & Yang Q. (2018). Cryopreserved Human Intestinal Mucosal Epithelium: A Novel In Vitro Experimental System for the Evaluation of Enteric Drug Metabolism, Cytochrome P450 Induction, and Enterotoxicity. Drug metabolism and disposition: the biological fate of chemicals, 46(11).

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