mpMRIs of the prostate were acquired at 3T Discovery MR750 magnet (GE, Waukesha, WI) with 32-channel phased array pelvis coil. Axial T2 weighted-MRI (T2w): 2D Fast spinecho, 1.25×1.25×2.5mm resolution; acquisition matrix = 256×256 and 72 slices (no gap); repetition time (TR)/echo time (TE)/Number of Excitations (NEX)=5700/85/1; echo train length =16; flip angle 120°; (i) Diffusion Weighted Imaging (DWI): single-shot echo-planar imaging (EPI) utilizing the diffusion-module and fat-suppression pulses; 2.5×2.5×2.5 mm resolution; acquisition matrix 128×128 and 36 slices; TR/TE/NEX 9500/53/1; b-values 50, 500 and 1000 s/mm2. The ADC map was calculated on the GE MR console, using a mono-exponential fit. (ii) Twelve DCE series were acquired with the same spatial resolution and spacing as the T2w, using a dynamic 3D fast spoiled gradient echo T1 weighted (T1w) sequence utilizing a parallel imaging, acceleration factor of 2; temporal resolution: 30–34s, TR=3.77–4.05 ms, TE=1.69–1.78 ms following intravenous bolus injection of a paramagnetic gadolinium chelate - 0.1 mmol of gadobenate-glumine (Bracco Diagnostics Inc., Princeton, NJ) per kilogram of body weight. The contrast is administered with a power injector (Spectris, Medrad Inc., Warrendale, PA) at 2 mL/s and followed by a 20-mL saline flush.
Gadobenate glumine
Manufactured by Bracco
Sourced in United States
Gadobenate-glumine is a contrast agent used in magnetic resonance imaging (MRI) procedures. It contains the active ingredient gadobenate dimeglumine, which is a paramagnetic compound that enhances the visibility of certain structures or tissues during MRI scans.
Automatically generated - may contain errors
Lab products found in correlation
2 protocols using gadobenate glumine
1
Multiparametric MRI of Prostate Cancer
2
Retrospective Review of Prostate mpMRI
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An Institutional Review Board (IRB) approved a protocol for retrospective review of mpMRI exams from prostate cancer patients. The IRB waived the need for informed consent. A total of 71 sequential patients, presenting for evaluation for radiation treatment (RT) between 2012 and 2015 and who underwent mpMRI exams on a 3T Discovery MR750 (GE, Waukesha, WI, USA) were identified from the departmental database.
mpMRI exam consisted in part of: (i) axial T2w-MRI of the pelvis: resolution 1.25 mm × 1.25 mm × 2.5 mm; field of view: 320 mm × 320 mm; slice thickness = 2.5 mm (no gap); 72 slices, and (ii) DCE-MRI—12 series of T1 weighted (T1w) at 30–34 s temporal resolution, TR = 3.77–4.05 ms, TE = 1.69–1.78 ms acquired following intravenous bolus injection of a paramagnetic gadolinium chelate—0.1 mmol of gadobenate-glumine (Bracco Diagnostics Inc., Princeton, NJ, USA) per kilogram of body weight. The contrast is administered with a power injector (Spectris, Medrad Inc., Warrendale, PA, USA) at 2 mL/s and followed by a 20-mL saline flush.
mpMRI exam consisted in part of: (i) axial T2w-MRI of the pelvis: resolution 1.25 mm × 1.25 mm × 2.5 mm; field of view: 320 mm × 320 mm; slice thickness = 2.5 mm (no gap); 72 slices, and (ii) DCE-MRI—12 series of T1 weighted (T1w) at 30–34 s temporal resolution, TR = 3.77–4.05 ms, TE = 1.69–1.78 ms acquired following intravenous bolus injection of a paramagnetic gadolinium chelate—0.1 mmol of gadobenate-glumine (Bracco Diagnostics Inc., Princeton, NJ, USA) per kilogram of body weight. The contrast is administered with a power injector (Spectris, Medrad Inc., Warrendale, PA, USA) at 2 mL/s and followed by a 20-mL saline flush.
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