Parp 1078 1

Manufactured by Abcam

Sourced in China

PARP (1078–1) is a recombinant human PARP1 protein. PARP1 is an enzyme involved in the cellular response to DNA damage. It catalyzes the addition of poly(ADP-ribose) chains to target proteins, which can lead to various cellular effects.

Automatically generated - may contain errors

Lab products found in correlation

Drp1 8570, by Cell Signaling Technology (2 mentions) Apocynin, by Selleck Chemicals (1 mentions) Chloroquine, by Merck Group (1 mentions) β actin a1978, by Merck Group (1 mentions) Gapdh af0006, by Beyotime (1 mentions)

2 protocols using parp 1078 1

Isorhamnetin Regulates Mitochondrial Dynamics

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Isorhamnetin was purchased from Must Biotechnology (Chengdu, China); chloroquine from Sigma-Aldrich; Mn-TBAP from Focus Biomolecules; apocynin was purchased from Selleck Chemicals (Shanghai, CA). The antibodies against cleaved-caspase 3 (9661), pro-caspase 3 (9668S), p62 (5114S), phospho-CamkII (T286, 12,716), phospho-Drp1 (S616, 3455), phospho-Drp1 (S637, 4876), and Drp1 (8570) were purchased from Cell Signaling Technology; PARP (1078–1) was purchased from Epitomics; β-actin (A1978) and LC3 (L754S) from Sigma-Aldrich; Bax (510804), Cleaved-PARP (380374), Bak (380976), NOX2 (381293), NOX4 (380874) and COX IV (200147) from Zen-Bio. Cytochrome. C (13156) and CamkII (5306) were purchased Santa Cruz Biotechnology.

Hu J., Zhang Y., Jiang X., Zhang H., Gao Z., Li Y., Fu R., Li L., Li J., Cui H, & Gao N. (2019). ROS-mediated activation and mitochondrial translocation of CaMKII contributes to Drp1-dependent mitochondrial fission and apoptosis in triple-negative breast cancer cells by isorhamnetin and chloroquine. Journal of Experimental & Clinical Cancer Research : CR, 38, 225.

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Antibodies for Apoptosis and Mitochondrial Dynamics

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Arnidiol was isolated from Tephroseris kirilowii (Turcz.) Holub. Antibodies against C-Caspase 3 (9661S), phospho-Drp1 (S616, 3455), phospho-Drp1 (S637, 4876), and Drp1 (8570) were purchased from Cell Signaling Technology (Boston, MA, USA); GAPDH (AF0006) was purchased from Beyotime (Shanghai, China); COX4 (200147) and Cleaved-PARP (380374) were purchased from Zen-bio (Chengdu, China); PARP (1078–1) was purchased from Epitomics (Burlingame, USA); ROCK1 (ab45171), phospho-Cofilin (S3, ab12866) were purchased from Abcam (Cambridge, UK); PP2A (610555) was purchased from BD Biosciences (Franklin, NJ, USA). Cofilin (sc-376,476), Cytochrome. C (sc-13,156), Fis1 (sc-376,447), MFF (sc-398,617), Mfn1 (sc-166,644), Mfn2 (sc-515,647), OPA1 (sc-393,296), PP1 (sc-7482) were purchased from Santa Cruz Biotechnology (Dallas, TX, USA).

Hu J., Zhang H., Li J., Jiang X., Zhang Y., Wu Q., Shen L., Shi J, & Gao N. (2020). ROCK1 activation-mediated mitochondrial translocation of Drp1 and cofilin are required for arnidiol-induced mitochondrial fission and apoptosis. Journal of Experimental & Clinical Cancer Research : CR, 39, 37.

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