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163 protocols using discovery mr750w

1

Dynamic Contrast-Enhanced MRI Protocol

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At site A, MR imaging was performed with one of the following MR systems: at 1.5 T (Optima-MR450w or Signa-HDxt; GE Healthcare, Waukesha, Wis) with an eight- or 12-channel phased-array coil or at 3.0 T (Discovery-MR750 or Discovery-MR750w; GE Healthcare) with a 12- or 32-channel phased-array coil. Dynamic contrast–material enhanced T1-weighted MR imaging was performed by using a three-dimensional spoiled gradient-echo acquisition with spectrally selective intermittent fat inversion (LAVA) with true in-plane spatial resolution of 1.1–1.5 × 1.9–2.0 mm (1.5 T) and 1.3 × 1.6–1.7 mm (3.0 T) with 5 mm (1.5 T) and 3.4 mm (3.0 T) section thicknesses. Image acquisition time was approximately 22 seconds (1.5 T) or 20 seconds (3.0 T).
At site B, MR imaging was performed with either a 1.5-T MR system (Signa-HDxt; GE Healthcare) with an eight-channel phased-array coil or a 3.0-T MR system (Discovery-MR750w; GE Healthcare) with a 32-channel phased-array coil. Dynamic MR imaging was performed with LAVA with a real spatial resolution of 1.1–1.2 × 2.1–2.4 mm (1.5 T) and 1.1–1.2 × 1.8–2.0 mm (3.0 T) with 5 mm (1.5 T) and 4 mm (3.0 T) section thicknesses. Image acquisition time was approximately 16 seconds at both 1.5 T and 3.0 T. Detailed MR parameters are in Table E1 (online).
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2

Multimodal MRI of Newborn Piglet Brain

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Magnetic resonance imaging (MRI) was performed using the Discovery MR750w 3.0T MR scanning device (GE Discovery MR750w) and a standard 32-channel head coil. Animals were positioned in a home-made wooden fixation box, and inhalation anesthesia was appropriately administered. Animals in both groups underwent conventional MRI (including T1- and T2-weighted imaging and T2-weighted fluid-attenuated inversion recovery imaging) and DKI scans at 3, 6, 9, 12, 16, and 24 h postoperatively. All sequences were scanned with coronal position. To ensure consistency of scanning layers at different time points of the same newborn piglet, the positioning line of each scan is maintained. DKI scanning involved a single-shot spin-echo imaging with the repetition time of 4500 ms and with minimal echo time; the direction of the diffusion-sensitive gradient was 20; the b values were 0, 1000, and 2000 s/mm2; the matrix was 128 × 128; and the field of view was 220 × 220 mm2. The layer thickness was 3.0 mm, the layer spacing was 0.5 mm, the number of excitations was 2, and the scanning time was 14 min and 45 s. Parameters for both DKI and diffusion tensor imaging were obtained simultaneously.
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3

Pelvic MRI Screening for Normal Subjects

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All pelvic MRI data were acquired using a 3-T scanner (Discovery MR750w; GE Healthcare, Waukesha, WI, USA). Two radiologists with 18 and 3 years of radiological experience, respectively, performed visual examinations to confirm that the subjects did not have mass lesions in the pelvic MRIs (T2-weighted image, T1-weighted image, and diffusion-weighted image). Any disagreements in interpretation were resolved by consensus following the discussion. Radiologists diagnosed all enrolled subjects as normal.
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4

Spinal Cord MRI at 14 Days Post-Injury

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Magnetic resonance imaging (MRI) was used to evaluate the intraspinal spinal cord at 14 dpi using a 3.0-Tesla MR system (Discovery MR750w, General Electric, Milwaukee, WI, USA) with a rat whole body coil. Sagittal T2 and T2 fat-suppressed images were obtained with the following parameters: repetition time = 4079 ms; echo time = 21 ms; field of view = 10 cm × 8 cm; slice thickness = 1.5 mm.
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5

3T MRI Protocols for Brain Imaging

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MRI was performed at both the University of Fukui and Osaka University. At the University of Fukui, a 3-T MR scanner (Discovery MR 750; General Electric Medical Systems) was used for high-resolution T1-weighted anatomical MRI (repetition time = 6.38 ms, echo time = 1.99 ms, flip angle = 11°, field of view = 256 × 256 mm2, 256 × 256 matrix size, 172 slices, voxel dimensions = 1.0 × 1.0 × 1.0 mm3). At Osaka University, two kinds of 3-T MR scanners (Discovery MR 750w and Signa Excite HDxt; General Electric Medical Systems) were used for high-resolution T1-weighted anatomical MRI (repetition time = 880 ms, echo time = 0.016 ms, flip angle = 5°, field of view = 256 × 256 mm2, 256 × 256 matrix size, 480 slices, voxel dimensions = 0.94 × 0.94 × 0.94 mm3; and repetition time = 10.084 ms, echo time = 3.04 ms, flip angle = 18°, field of view = 512 × 512 mm2, 512 × 512 matrix size, 248 slices, voxel dimensions = 0.43 × 0.43 × 0.43 mm3).
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6

Multiparametric Prostate MRI Protocol

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All images were acquired on a 3 Tesla scanner (Discovery MR750w or Signa HDXT, GE Healthcare), and consisted of axial T1-weighted (repetition time, 450–750 msec; echo time, 7–12 msec; section thickness, 5 mm; intersection gap, 1 mm; field of view, 28–36 cm; matrix, 256×256–512*512), high-resolution axial/coronal/sagittal T2-weighted sequences (repetition time, 2500–6500 msec; echo time, 100–120 msec; section thickness, 3–5 mm; intersection gap, 0–1 mm; field of view, 14–24 cm; matrix, 256×192– 512*512), and diffusion weighted imaging with multiple b-values (repetition time, 3500–8500 msec; echo time, 60–100 msec; field of view, 16–20 cm; section thickness, 3–5 mm; intersection gap 0–1mm; field of view 14–24 cm; matrix 256 × 256; b values between 0 and 1000 sec/mm2). Apparent diffusion coefficient (ADC) maps were generated from DWI using a monoexponential model. Two board-certified radiologists (N.L.R., A.G.W.) with 4 and 6 years of experience in interpreting prostate MRI, who were blinded to all clinical data and the patients’ CCR scores, read all MRIs. Recorded MRI features, including PI-RADS version 2 score [16 (link)], extracapsular tumor extension (ECE), and quantitative metrics, are listed in Table 1.
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7

Multimodal Neuroimaging Protocol for Epilepsy

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All participants underwent whole-brain high-resolution T1-weighted structural MRI scans before electrode implantation to aid with electrode localization after surgery. In addition, resting state fMRI data were collected and used as functional connectivity priors for MVAR model estimation. The scanner was a 3T GE Discovery MR750W with a 32-channel head coil. The pre-electrode implantation anatomical T1 scan (3D FSPGR BRAVO sequence) was obtained with the following parameters: FOV = 25.6 cm, flip angle = 12 deg., TR = 8.50 ms, TE = 3.29 ms, inversion time = 450 ms, voxel size = 1.01.00.8 mm. For resting state-fMRI, 5 blocks of 5-minute gradient-echo EPI runs (650 volumes) were collected with the following parameters: FOV = 22.0 cm, TR = 2260 ms, TE = 30 ms, flip angle = 80 deg., voxel size = 3.45 3.45 4.0 mm. For each participant, resting state-fMRI runs were acquired in the same session but non-contiguously (dispersed within an imaging session to avoid habituation). Participants were asked to keep their eyes open, and a fixation cross was presented through a projector.
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8

T2-Weighted MRI of Tumor-Bearing Mice

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The T2-weighted MRI of tumor bearing mice were conducted by using 3.0 T clinical scanner (Discovery MR750w, GE, America) after tail intravenous injection with FeO/MoS2-BSA nanocomposites (200 µL, 400 µg mL–1) for 0, 4, 12, and 24 h. The T2-weighted imaging was disposed with the following optimal parameters of instrument (TE = 104.6 ms,TR = 3000 ms, FOV = 200 × 200 mm).
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9

Multimodal Neuroimaging Protocol for Brain Analysis

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High-resolution 3D T1-weighted structural images, DTI data, and resting-state blood-oxygen-level-dependent (BOLD) fMRI were obtained using a 3.0-Tesla MR system (Discovery MR750w, General Electric, Milwaukee, WI, United States) with a 24-channel head coil. The software packages FMRIB Software Library (FSL),1 Diffusion Toolkit (DTK),2 and Pipeline for Analyzing braiN Diffusion imAges (PANDA)3 were used for the DTI preprocessing steps. Resting-state BOLD data were preprocessed using SPM12 and Data Processing and Analysis for Brain Imaging (DPABI).4 The details are described in Supplementary Methods.
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10

Quantitative MRI Relaxation Mapping

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The phantoms were scanned by two-dimensional (2D) quantification of relaxation times and proton density by multiecho acquisition of a saturation-recovery using turbo spin-echo readout (QRAPMASTER) pulse sequence1 (link) using a 3.0T MRI system (Discovery MR750w, GE Healthcare). Imaging parameters were set as follows: TR, 4000 ms; TE, 16.9 and 84.5 ms; delay times, 146, 546, 1879, and 3879 ms; echo train length (ETL), 10; acceleration factor, 2; FOV 240 × 240 mm2; matrix, 512 × 512; bandwidth (BW), 31.25 Hz; slice thickness/gap, 4 mm/1 mm; slices, 20. T1 quantitative maps were retrieved on a commercially available standalone version of SyMRI 8.0.0 software (SyntheticMR, Linkoping, Sweden).
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