Cinnarizine

Manufactured by Merck Group

Sourced in Germany, United States

Cinnarizine is a laboratory equipment product. It is a chemical compound used in various research and analytical applications.

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Lab products found in correlation

6 protocols using cinnarizine

Quantitative Analysis of Pharmaceutical Compounds

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Tetrahydrofuran (HPLC grade), curcumin, cinnarizine and fenofibrate were purchased from Sigma-Aldrich (Steinheim, Germany). Betamethasone valerate was obtained from Caelo (Hilden, Germany). Sodium azide, hydrochloric acid and sodium hydroxide were ordered from Carl Roth (Karlsruhe, Germany), flufenamic acid from TCI (Zwijndrecht, Belgium) and dibucaine from Molekula (München, Germany). Phosphoric acid was from Merck (Darmstadt, Germany). Lipofundin® MCT/LCT 10% and Propofol-Lipuro® 10 mg/mL were from B.Braun (Melsungen, Germany), Disoprivan® 1% was from AstraZeneca (Wedel, Germany).

Francke N.M, & Bunjes H. (2020). Influence of drug loading on the physical stability of phospholipid-stabilised colloidal lipid emulsions. International Journal of Pharmaceutics: X, 2, 100060.

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Solubility Enhancement Formulations

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Cinnarizine,
griseofulvin,
haloperidol, indomethacin, ketoconazole, niclosamide, porcine pancreatin
(8 × USP specifications activity), soybean oil (long-chain triglyceride),
Cremophor EL (surfactant), and Carbitol (cosolvent) were purchased
from Sigma-Aldrich (St. Louis, USA). Danazol was purchased from Toronto
Research Chemicals, Inc. (Toronto, Canada), and felodipine was a gift
from AstraZeneca (Mölndal, Sweden). Captex 355 (medium-chain
triglyceride) and Capmul MCM EP (medium-chain mono-, di-, and triglyceride)
were donated by Abitec (Janesville, USA), and Maisine 35–1
(long-chain mono-, di-, and triglyceride) was a gift from Gattefossé
(Lyon, France). FaSSIF powder was bought from biorelevant.com (Croydon,
UK). HPLC-solvents were bought from VWR International (Spånga,
Sweden).

Alskär L.C., Keemink J., Johannesson J., Porter C.J, & Bergström C.A. (2018). Impact of Drug Physicochemical Properties on Lipolysis-Triggered Drug Supersaturation and Precipitation from Lipid-Based Formulations. Molecular Pharmaceutics, 15(10), 4733-4744.

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Dissolution Study of Pharmaceutical Compounds

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Itraconazole, naproxen and phenytoin were obtained from Chemie Brunschwig (Basel, Switzerland). Cinnarizine, ketoconazole, probenecid, sodium chloride, sodium hydroxide and sodium phosphate dihydrate were obtained from Sigma-Aldrich (Steinheim, Germany). Dimethyl sulfoxide was obtained from VWR Chemicals (Søborg, Denmark). SIF powder was obtained from Biorelevant (South Croydon, UK). HPMCAS-L was gifted by Dow Wolf Cellulosics (Bomlitz, Germany) and PVPVA64 was obtained from BASF (Basel, Switzerland). All materials were used as received.

Blaabjerg L.I., Grohganz H., Lindenberg E., Löbmann K., Müllertz A, & Rades T. (2018). The Influence of Polymers on the Supersaturation Potential of Poor and Good Glass Formers. Pharmaceutics, 10(4), 164.

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Synthesis and Characterization of Liquid Crystalline Polymers

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Molecules 1 and 3 were purchased at Synthon Chemicals. Molecule 2 was kindly provided by Philips Research Organics. Molecule 1 shows the following phase behavior: C_r 21.5°C SmA 33.5°C N 40.5°C I. Molecule 4 was purchased from Ciba. Typically, thin polymer films were fabricated from a mixture containing 69 wt % molecule 1, 15 wt % monomer 2, 15 wt % monomer 3, and 1 wt % photoinitiator 4. Tinuvin 328 was purchased from Ciba. 4-(Dimethylamino)azobenzene (methyl yellow), ibuprofen, and cinnarizine were purchased from Sigma-Aldrich. Sulfuric acid (95 wt %, Sigma-Aldrich) was diluted with deionized water to an aqueous solution of 0.1 M. Glass substrates with interdigitated indium tin oxide electrodes were purchased from Suzhou Walthy.

Zhan Y., Zhou G., Lamers B.A., Visschers F.L., Hendrix M.M., Broer D.J, & Liu D. (2020). Artificial Organic Skin Wets Its Surface by Field-Induced Liquid Secretion. Matter, 3(3), 782-793.

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In Vitro Permeability Assay Protocol

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Bovine bile, bovine serum albumin (BSA), calcein, cinnarizine, 4-bromophenylboronic acid (4-BPBA), maleic acid, pancreatin from porcine pancreas (≥3 × USP specifications), propylene glycol, soybean oil, and tris(hydroxymethyl)aminomethane (Tris) were purchased from Sigma Aldrich (St. Louis, MO, USA) at analytical grade. Acetonitrile (ACN), ammonium phosphate monobasic, ethanol absolute, hydrochloric acid (37%), methanol, potassium dihydrogen phosphate, and sodium hydroxide were purchased from VWR Chemicals (Leuven, Belgium). Kolliphor RH 40 and Maisine 35-1 were kindly donated by BASF (Ludwigshafen, Germany) and by Gattefossé (Saint-Priest, France), respectively. Lipoid S PC was obtained from Lipoid (Ludwigshafen, Germany). The PermeaPad^® barriers (25 mm) were generously donated by InnoME (Espelkamp, Germany). All water used in the experiments was of purified quality obtained from SG ultra-clear UV apparatus from Holm & Halby Service (Brøndby, Denmark).

Klitgaard M., Müllertz A, & Berthelsen R. (2021). Estimating the Oral Absorption from Self-Nanoemulsifying Drug Delivery Systems Using an In Vitro Lipolysis-Permeation Method. Pharmaceutics, 13(4), 489.

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Formulation and Characterization of Fenofibrate and Cinnarizine

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Fenofibrate (≥ 99%) and cinnarizine (≥ 99%) were purchased from Sigma-Aldrich (Gillingham, Kent, UK). Gelucire ® Sodium chloride (≥ 99%) was obtained from Chem-Supply (Gillman, South Australia, Australia) and an analytical grade hydrochloric acid (36% assay) was purchased from Biolab Pty. Ltd. (Clayton, Victoria, Australia). Water was sourced from a Millipore water purification system using a Quantum TM EX Ultrapure Organex cartridge (Millipore, Sydney, Australia).

Vithani K., Goyanes A., Jannin V., Basit A.W., Gaisford S, & Boyd B.J. (2019). A Proof of Concept for 3D Printing of Solid Lipid-Based Formulations of Poorly Water-Soluble Drugs to Control Formulation Dispersion Kinetics. Pharmaceutical research, 36(7).

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