The instruments used in this study included XL-4450/LL-4450 (light source), VP-4450HD (processor), EC-L590ZW/EC-600ZP (scope) (Fujifilm Co., Tokyo, Japan) and CLV-290SL (light source), CV-290 (processor), and CF-H260AZI/CF-HQ290I (scope) (Olympus Co., Tokyo, Japan). The participating physicians were 22 expert endoscopists who had each performed > 1000 colonoscopies, including polypectomies. The snare used in this study included Snare Master 15 mm (Olympus Co., Tokyo, Japan), Profile 11 mm/13 mm and Captivator II 10 mm (Boston Scientific Co., Boston, MA, United States) in both groups. Additionally, as the biopsy forceps, Radial Jaw 4 JUMBO in the CP group and Radial Jaw 4 in the HP group (Boston Scientific Co., Boston, MA, United States) were used. In principle, the biopsy forceps were used for lesions < 4 mm, while the snare was used for lesions ≥ 4 mm because the histological complete resection rate for lesions ≥ 4 mm is lower with cold forceps polypectomy (CFP)[16 (link)]. The physicians decided whether to use the biopsy forceps or the snare. We determined the size of the lesion based on the outer diameter of the tip cup diameter of the biopsy forceps or the snare.
Vp 4450hd
Manufactured by Fujifilm
Sourced in Japan
The VP-4450HD is a lab equipment product from Fujifilm. It is a high-definition video processor designed for use in medical and scientific applications. The product's core function is to process and output high-quality video signals.
Automatically generated - may contain errors
Lab products found in correlation
Ll 4450, by Fujifilm (2 mentions)
Eg l590zw, by Fujifilm (2 mentions)
Gif h290z, by Olympus (2 mentions)
Gif h260z, by Olympus (2 mentions)
Gif hq290, by Olympus (2 mentions)
Cv 290, by Olympus (1 mentions)
Clv 290sl, by Olympus (1 mentions)
Radial jaw 4, by Boston Scientific (1 mentions)
Captivator 2 10 mm, by Boston Scientific (1 mentions)
Eg l600zw, by Fujifilm (1 mentions)
Ec l590zw, by Fujifilm (1 mentions)
Ec l600zp, by Fujifilm (1 mentions)
Lasereo laser endoscope system, by Fujifilm (1 mentions)
Cv 260sl, by Olympus (1 mentions)
Eg l600zw7, by Fujifilm (1 mentions)
Gif xp260n, by Olympus (1 mentions)
Evis lucera elite cv 290, by Olympus (1 mentions)
Gif xp290n, by Olympus (1 mentions)
Evis lucera cv 260, by Olympus (1 mentions)
Eg 580 nw, by Fujifilm (1 mentions)
6 protocols using vp 4450hd
1
Colonoscopic Polypectomy Techniques Comparison
2
Endoscopic Imaging of Early Gastric Cancer
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All examinations were carried out by 4 skilled endoscopists accredited by the Japan Gastroenterological Endoscopy Society, with EG-L590ZW and EG-L600ZW endoscopes corresponding to the LASEREO system, consisting of a VP-4450HD processor and an LL 4450 light source (FUJIFILM Co., Tokyo, Japan) (Video S1 ). Endoscopic video clips of the entire gastric mucosa were recorded for about a min using WLI, BLI-bright, and LCI after washing and removing gastric mucus (Figure 1 a,b). At this time, we paid particular attention to keeping the shooting speed as constant as possible. Next, a close-up movie of the EGCs was recorded for several seconds using WLI, BLI-bright, and LCI. At this time, we recorded a movie of the entire lesion in the front view from a short or middle distance (Figure 1 c,d,f). Then, low magnifying movies of EGC with the demarcation line at the oral or anal side of the lesion were recorded for several seconds using WLI and each IEE (Figure 1 e).
3
Advanced Colonoscopy Imaging Techniques
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All examinations were carried out using a LASEREO laser endoscope system (Fujifilm Co., Tokyo,
Japan) consisting of high-resolution colonoscopes (EC-L590ZW and EC-L600ZP), a light source
(LL-4450), and a video processor (VP-4450HD). This system utilizes a semiconductor laser as the
light source and has narrow-band light functions, which can produce 4 types of imaging including
WLI, BLI, BLI-bright, and LCI
12 (link)
13 (link)
14 (link)
. BLI is performed with a
combination of strong laser light at a wavelength of 410 nm and weak laser light at a wavelength
of 450 nm. BLI-bright is set by controlling the power of the 2 lasers and an appropriate
combination of WLI and BLI. LCI is a novel image-enhancement technology based on images captured
under conditions similar to those of BLI-bright
14 (link)
15 (link)
. It
utilizes digital processing to enhance slight color differences in hue in the red region of the
spectrum
22 (link)
(
Supplementary Fig. 1 ). Each observation mode can be switched easily by pushing a button on the colonoscope manipulation handle.
+ Expand
All examinations were carried out using a LASEREO laser endoscope system (Fujifilm Co., Tokyo,
Japan) consisting of high-resolution colonoscopes (EC-L590ZW and EC-L600ZP), a light source
(LL-4450), and a video processor (VP-4450HD). This system utilizes a semiconductor laser as the
light source and has narrow-band light functions, which can produce 4 types of imaging including
WLI, BLI, BLI-bright, and LCI
12 (link)
13 (link)
14 (link)
. BLI is performed with a
combination of strong laser light at a wavelength of 410 nm and weak laser light at a wavelength
of 450 nm. BLI-bright is set by controlling the power of the 2 lasers and an appropriate
combination of WLI and BLI. LCI is a novel image-enhancement technology based on images captured
under conditions similar to those of BLI-bright
14 (link)
15 (link)
. It
utilizes digital processing to enhance slight color differences in hue in the red region of the
spectrum
22 (link)
(
4
Diagnostic Capability of DCSS for Early Gastric Lesions
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We sought to assess the diagnostic capability of the DCSS using white light, non-magnified images by retrospectively analyzing of our database. This system uses only white light, non-magnified images. We enrolled 855 cases who underwent EGD and were diagnosed with early gastric carcinoma (EGC) or malignant lymphoma (ML) at Chiba University Hospital and Chiba Foundation for Health Promotion and Disease Prevention from September 2014 to January 2019. For GC, we included only cases in the early stage that were considered eligible for endoscopic treatment, and excluded cases in the advanced stage that were eligible for surgery or chemotherapy. Multiple endoscopists captured the endoscopic images using standard endoscopes [GIF-H260, GIF-XP260NS, GIF-H260Z, GIF-Q260J, GIF-H290, GIF-HQ290, GIF-H290Z, GIF-H290T, GIF-XP290N (Olympus Corporation, Tokyo, Japan], EG-580NW, EG-590WR, and EG-L600ZW7 (Fujifilm, Tokyo)] and standard video processors [EVIS LUCERA CV-260, CV-260SL, EVIS LUC-ERA ELITE CV-290 (Olympus), Advancia VP-4450, VP-4450HD, and LASEREO VP-7000 (Fujifilm)].
5
Gastric Lesion Evaluation with Endoscopic Imaging
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Four datasets were used for training, validation, and testing the models, including training and validating set (Dataset 1), image test set (Dataset 2), video test set (Dataset 3), and prospective test set (Dataset 4). The detailed information of four dataset were presented in the supplementary materials.
Inclusion criteria: the lesions were viewed at WL and WM mode. Exclusion criteria: the lesions were hard to evaluate because of poor-quality views, resulting from active bleeding, thick white coats, blurs, defocus, mucus, and so on.
Two senior endoscopists were involved in labeling images, selecting and editing videos, both of whom had an experience of EGD over 5 years.
The equipment used in this study included standard gastroscopes [(EG-L590ZW; Fujifilm, Tokyo, Japan), (GIF-HQ290, GIF-H260Z, GIF-H290Z; Olympus Medical Systems, Tokyo, Japan)] and video systems [(ELUXEO 7000, LASEREO7000 and VP-4450HD; Fujifilm, Tokyo, Japan), (EVIS LUCERA CV-260/CLV-260 and EVIS LUCERA ELITE CV-290/CLV-290SL; Olympus Medical Systems, Tokyo, Japan)].
Inclusion criteria: the lesions were viewed at WL and WM mode. Exclusion criteria: the lesions were hard to evaluate because of poor-quality views, resulting from active bleeding, thick white coats, blurs, defocus, mucus, and so on.
Two senior endoscopists were involved in labeling images, selecting and editing videos, both of whom had an experience of EGD over 5 years.
The equipment used in this study included standard gastroscopes [(EG-L590ZW; Fujifilm, Tokyo, Japan), (GIF-HQ290, GIF-H260Z, GIF-H290Z; Olympus Medical Systems, Tokyo, Japan)] and video systems [(ELUXEO 7000, LASEREO7000 and VP-4450HD; Fujifilm, Tokyo, Japan), (EVIS LUCERA CV-260/CLV-260 and EVIS LUCERA ELITE CV-290/CLV-290SL; Olympus Medical Systems, Tokyo, Japan)].
6
Endoscopic Ultrasound for Lesion Evaluation
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EUS was performed using conventional echoendoscopes (GF-UCT240, GF-UE260-AL5, GF-UCT260, TGF-UC260J, or GF-UM2000: Olympus Corporation, Tokyo, Japan; EG-530UR, EG-580UR, or EG-580UT: Fujifilm Corporation, Tokyo, Japan; EG-3830UT or EG-3870UTK: Pentax Lifecare Division, Hoya Co, Ltd, Tokyo, Japan) at 5-20 MHz or mini-probes (UM-2R, frequency 12 MHz, UM-3R, frequency 20 MHz, or UM-DP20-25R, frequency 20 MHz: Olympus Corporation; P-2726-12, frequency 12 MHz or P-2726-20, frequency 20 MHz: Fujifilm Corporation) and ultrasound systems (EU-ME1 or EU-ME2: Olympus Corporation; VP-4450HD, SU-1, or SP900: Fujifilm Corporation; ARIETTA 850, Prosound F75, or Prosound SSD α-10: Hitachi Aloka Medical, Tokyo, Japan). The lesion was scanned after removing mucus and foam and filling the upper gastrointestinal tract with degassed water. The frequency was set high (12 or 20 MHz) for the observation of the originating layer of the lesion and was changed to a lower one (5-7.5 MHz) when the entire image could not be obtained.
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