Cladribine

Manufactured by Cayman Chemical

Sourced in United States

Cladribine is a synthetic purine nucleoside analogue. It is a white, crystalline powder that is soluble in water and various organic solvents.

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Lab products found in correlation

3 protocols using cladribine

Catalog of Diverse Chemical Compounds

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Individual chemicals, i.e., albendazole, alexidine, azelastine, bosutinib, carmofur, cladribine, digoxigenin, dronedarone, emetine, miconazole, pentamidine, pitavastatin, sertraline, solifenacin, sulcanozole, tadalafil, terfenadine, thioridazine, trifluorothymidine, and toremifene were purchased from Cayman Chemical Company (Ann Arbor, MI, USA). Additionally, 10-deacetylbaccatin, allyl-thiourea, aminoacridine, bazedoxifene, cephalomannine, cetrimonium bromide, ciclopirox, clomifene, cytarabine, fenbendazole, ouabain, oxethazaine, penfluridol, pyrithione zinc, tioconazole, thioguanine, and vinorelbine were purchased from Sigma-Aldrich. Flubendazole was purchased from LKT Laboratories, Inc. (St. Paul, MN, USA), and gemcitabine and niclosamide were purchased from AdipoGen^® Life Science (Liestal, Switzerland), whereas thonzonium bromide and pralatrexate were purchased from MedChemExpress (Monmouth Junction, NJ, USA).

Dell’Anno I., Melani A., Martin S.A., Barbarino M., Silvestri R., Cipollini M., Giordano A., Mutti L., Nicolini A., Luzzi L., Aiello R., Gemignani F, & Landi S. (2022). A Drug Screening Revealed Novel Potential Agents against Malignant Pleural Mesothelioma. Cancers, 14(10), 2527.

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Characterization of Nucleoside Analogue Uptake

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NBMPR‐P was purchased from Toronto Research Chemicals. NBMPR was purchased from Tocris Bioscience. Clofarabine, cladribine, and lamivudine were purchased from Cayman Chemical. Sterile 1X Phosphate Buffered Saline was purchased from Research Products International. Heparin was purchased from Alfa Aesar. Poly‐L‐lysine was purchased from Sciencell. PEG‐400 was purchased from Sigma‐Aldrich. Collagenase type 1 was purchased from Worthington Biochemical Corporation. Additional reagents were purchased from Thermo Fisher Scientific unless otherwise noted.

Miller S.R., Jilek J.L., McGrath M.E., Hau R.K., Jennings E.Q., Galligan J.J., Wright S.H, & Cherrington N.J. (2021). Testicular disposition of clofarabine in rats is dependent on equilibrative nucleoside transporters. Pharmacology Research & Perspectives, 9(4), e00831.

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Cytotoxicity Assessment of Chemotherapeutics

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Cells were plated in 96-well plates at 1 ×10⁴/well (suspension) and 3 × 10³/well (adherent) and exposed to cytarabine (Ara-C), fludarabine, or cladribine (Cayman Chemicals), or hydroxyurea (HU; Sigma) in triplicate. Relative cell numbers were quantified at the indicated time points by CellTiter-Glo (Promega) for suspension cultures or by AlamarBlue (Thermo Fisher) for adherent cells. Plates were read with a BMG LABTECH FluoroQuant Optima plate reader. Relative cell viability data normalized to vehicle controls set at 100% were used to calculate IC₅₀ values by fitting a four-parameter (variable slope) dose–response curve. GraphPad Prism version 7 software was used.

Venugopal K., Feng Y., Nowialis P., Xu H., Shabashvili D.E., Berntsen C.M., Kaur P., Krajcik K.I., Taragjini C., Zaroogian Z., Casellas Román H.L., Posada L.M., Gunaratne C., Li J., Dupéré-Richer D., Bennett R.L., Pondugula S., Riva A., Cogle C.R., Opavsky R., Law B.K., Bhaduri-McIntosh S., Kubicek S., Staber P.B., Licht J.D., Bird J.E, & Guryanova O.A. (2021). DNMT3A Harboring Leukemia-Associated Mutations Directs Sensitivity to DNA Damage at Replication Forks. Clinical Cancer Research, 28(4), 756-769.

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