B6.129s6 ch25htm1rus j

All mice were specific pathogen-free, maintained under a 12-hr light-dark cycle (7AM to 7PM), and given a standard chow diet (Harlan irradiated laboratory animal diet) ad libitum. Within each experiment mice of all genotypes were age-matched at 6-10 weeks old at the beginning of infections. Whenever possible we used comparable numbers of each sex across all genotypes in an experiment. Mice work was not subjected to randomization or data blinding. C57BL/6J (B6), B6.129S-Il1rn^tm1Dih/J (Il1rn^−/−, Jax #004754)⁵⁸ , B6(Cg)-Ifnar1^tm1.2Ees/J (Ifnar^−/−, Jax #028288) and B6.129S6-^Ch25htm1Rus/J (Ch25h^−/−, JAx #016263)^{71 (link)} were originally purchased from Jackson Laboratories and subsequently bred at UC Berkeley. B6J.C3-Sst1^{C3HeB/FeJKrmn} mice (referred to as B6.Sst1^S throughout) were from the colony of I. Kramnik at Boston University and then transferred to UC Berkeley. Sting^gt/gt mice were previously described^{72 (link)}. All animals used in experiments were bred in-house unless otherwise noted in the figure legends. All animal experiments complied with the regulatory standards of, and were approved by, the University of California Berkeley Institutional Animal Care and Use Committee.