Fmoc ala oh

Manufactured by Mimotopes

Sourced in Australia

Fmoc-Ala-OH is an amino acid building block used in solid-phase peptide synthesis. It consists of the amino acid alanine (Ala) with a 9-fluorenylmethyloxycarbonyl (Fmoc) protecting group. This protected amino acid can be used to incorporate alanine residues into peptide sequences during automated peptide synthesis.

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Lab products found in correlation

Acetonitrile, by Merck Group (2 mentions) Fmoc dab ivdde oh, by Chem-Impex (2 mentions) Fmoc thr tbu oh, by Mimotopes (2 mentions) 1 1 1 3 3 3 hexafluoro 2 propanol hfip, by Chem-Impex (2 mentions) Dansyl chloride, by Merck Group (1 mentions) Piperidine, by Merck Group (1 mentions) Diphenylphosphorylazide dppa, by Merck Group (1 mentions) Fmoc d leu oh, by Chem-Impex (1 mentions) Ethanedithiol edt, by Merck Group (1 mentions) Hydrazine, by Merck Group (1 mentions) Fmoc leu oh, by Mimotopes (1 mentions) Fmoc d phe oh, by Chem-Impex (1 mentions)

2 protocols using fmoc ala oh

Peptide Synthesis and Characterization

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Diisopropylethylamine (DIPEA) was obtained from Auspep (Melbourne, Australia). Fmoc-L-OctGly-OH and Fmoc-Dab(Boc)-OH were obtained from Try-lead Chem (Hangzhou, China). Fmoc-Dab(ivDde)-OH, Fmoc-D-Leu-OH, 1H-Benzotriazolium-1-[bis(dimethylamino)methylene]-5-chloro hexafluoro- phosphate-(1-),3-oxide (HCTU) and 1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) were obtained from Chem-Impex International (Wood Dale, IL, USA). Fmoc-Thr(tBu)-OH, Fmoc-Ala-OH and Fmoc-Gly-OH were obtained from Mimotopes (Melbourne, Australia). N-Fmoc-Amido-dPEG₂-OH was obtained from Peptides International (Louisville, KY, USA). Dichloromethane (DCM), dimethylformamide (DMF), diethyl ether and acetonitrile were obtained from Merck (Melbourne, Australia). Fmoc-Thr(tBu)-TCP-Resin was obtained from Intavis Bioanyltical Instruments (Köln, Germany). Piperidine, triisopropylsilane (TIPS), trifluoroacetic acid (TFA), dansyl-chloride, ethanedithiol (EDT) and diphenylphosphorylazide (DPPA) were obtained from Sigma-Aldrich (Castle Hill, Australia) Polymyxin B sulfate and colistin sulfate were research grade and obtained from BetaPharma (Shanghai, China).

Yun B., Roberts K.D., Thompson P.E., Nation R.L., Velkov T, & Li J. (2017). Design and Evaluation of Novel Polymyxin Fluorescent Probes. Sensors (Basel, Switzerland), 17(11), 2598.

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Synthesis of Peptides with Fmoc Chemistry

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The general synthetic methodology used for the synthesis of the peptides has been previously described in detail elsewhere by our group.^{43 (link)} The materials and synthesis protocol used are also presented below.
Piperidine, diisopropylethylamine (DIPEA) and trifluoroacetic acid (TFA) were purchased from Auspep (Melbourne, Australia). Fmoc-Dab(Boc)-OH, was purchased from Try-lead Chem (Hangzhou, China). Fmoc-d-Phe-OH, Fmoc-Dab(ivDde)-OH, 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) and 1H-benzotriazolium-1-[bis(dimethylamino)methylene]-5-chloro hexafluoro phosphate-(1-),3-oxide (HCTU) were purchased from Chem-Impex International (Wood Dale, IL, USA). Fmoc-Ala-OH, Fmoc-Leu-OH and Fmoc-Thr(tBu)-OH were purchased from Mimotopes (Melbourne, Australia). Dimethylformamide (DMF), methanol (MeOH), diethyl ether, dichloromethane (DCM), hydrochloric acid (HCl) and acetonitrile were purchased from Merck (Melbourne, Australia). Fmoc-Thr(tBu)-TCP-Resin was purchased from Intavis Bioanayltical Instruments (Germany). Triisopropylsilane (TIPS), 1,2-ethanedithiol (EDT), diphenylphosphorylazide (DPPA) and hydrazine were obtained from Sigma-Aldrich (Castle Hill, Australia).

Jiang X., Patil N.A., Azad M.A., Wickremasinghe H., Yu H., Zhao J., Zhang X., Li M., Gong B., Wan L., Ma W., Thompson P.E., Yang K., Yuan B., Schreiber F., Wang L., Velkov T., Roberts K.D, & Li J. (2021). A novel chemical biology and computational approach to expedite the discovery of new-generation polymyxins against life-threatening Acinetobacter baumannii. Chemical Science, 12(36), 12211-12220.

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