High-resolution structural imaging was acquired on a Siemens 3.0 T Magnetom Trio Tim MR scanner (the first dataset) or General Electric (GE) Discovery MR750 3.0 T scanner (the second dataset) using protocols described elsewhere (Xi et al., 2016 (link); Cui et al., 2017a (link),b (link)). All the imaging data were collected in the Department of Radiology, Xijing Hospital. A custom-built head coil cushion and earplugs were used to minimize head motion and dampen scanner noise. During data acquisition, subjects were asked to remain alert with eyes closed and keep their head still. Participants in dataset 1 underwent scanning using a 3.0-T Siemens Magnetom Trio Tim scanner and an eight-channel phased array head coil (Siemens, Germany). Participants in dataset 2 underwent scans on a GE Discovery MR750 3.0-T scanner and an eight-channel phased array head coil (Milwaukee, WI, United States). Detailed parameters of high-resolution T1-weighted anatomical data are listed in Table 2 . As performed previously (Cui et al., 2018 (link)), steps for the following analysis are shown in Figure 1 .
Discovery mr750 3.0t scanner
Manufactured by GE Healthcare
Sourced in United States
The Discovery MR750 3.0T scanner is a magnetic resonance imaging (MRI) system developed by GE Healthcare. It operates at a field strength of 3.0 Tesla and is designed to provide high-quality images for medical diagnostic purposes.
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Lab products found in correlation
8 channel head coil, by GE Healthcare (6 mentions)
8 channel phased array receiving coil, by GE Healthcare (2 mentions)
Magnetom trio tim scanner, by Siemens (1 mentions)
Eight channel phased array head coil, by GE Healthcare (1 mentions)
Eight channel phased array head coil, by Siemens (1 mentions)
32 channel head coil, by GE Healthcare (1 mentions)
Omniscan, by GE Healthcare (1 mentions)
Discovery mr750w 3.0t scanner, by GE Healthcare (1 mentions)
Skyra 3.0t scanner, by Siemens (1 mentions)
Somatom definition flash, by Siemens (1 mentions)
Eight channel head coil, by GE Healthcare (1 mentions)
Mimics innovation suite 16, by Materialise (1 mentions)
Lenstar ls 900, by Haag-Streit (1 mentions)
Matlab 2018a, by MathWorks (1 mentions)
45 protocols using discovery mr750 3.0t scanner
1
High-Resolution Structural Brain Imaging
2
3T MRI Protocol for Brain Iron Quantification
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Participants were scanned on a GE Discovery MR750 3.0T scanner, equipped with an 8-channel phased array receiving coil, at the MR center, Karolinska University Hospital, Stockholm. A structural T1-weighted 3D IR-SPGR image was obtained with the following parameters: repetition time (TR) = 6.96 ms, echo time (TE) = 2.62 ms, 176 axial slices with slice thickness of 1 mm, in-plane resolution = 0.94 × 0.94 mm2, field of view (FOV) = 24 cm, flip angle = 12°. For brain iron quantification, a 3D multi-echo Gradient Recalled Echo (meGRE) sequence was used with the following parameters: TR = 27.2 ms, 124 axial slices of 1.2 mm thickness, in-plane resolution = 0.94 × 0.94 mm2, FOV = 24 cm, flip angle = 17°. The first TE was 1.9 ms, and it was followed by 7 consecutive TEs with a constant interval of 3.18 ms between them.
3
Multimodal Neuroimaging of Alzheimer's Disease
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Image acquisitions were performed in Shanghai Key Laboratory of Magnetic Resonance on a 3T MR scanner (Discovery MR750 3.0T scanner, GE Healthcare, US) with a 64 channel head coil. A high-resolution three-dimensional T1-weighted imaging was performed with the following parameters: slice number = 192, slice thickness = 1 mm, repetition time (TR) = 2,530 ms, echo time (TE) = 2.98 ms, field of view (FOV) = 224 mm × 224 mm, gap = 0 mm, acquisition matrix = 64 × 64.
Resting-state data were performed with the following parameters: slice number = 35, slice thickness = 3.5 mm, repetition time (TR) = 500 ms, echo time (TE) = 30 ms, field of view (FOV) = 224 mm × 224 mm, gap = 0.525 mm, acquisition matrix = 64 × 64, flip angle = 60°, total time = 8 min 7 s.
During the scan, participants were asked to relax with their eyes closed but not to fall asleep. Images of patients with AD were acquired at baseline and week 12, respectively. Healthy subjects received the fMRI scan only one time at baseline.
Resting-state data were performed with the following parameters: slice number = 35, slice thickness = 3.5 mm, repetition time (TR) = 500 ms, echo time (TE) = 30 ms, field of view (FOV) = 224 mm × 224 mm, gap = 0.525 mm, acquisition matrix = 64 × 64, flip angle = 60°, total time = 8 min 7 s.
During the scan, participants were asked to relax with their eyes closed but not to fall asleep. Images of patients with AD were acquired at baseline and week 12, respectively. Healthy subjects received the fMRI scan only one time at baseline.
4
Simultaneous EEG-fMRI Neuroimaging Protocol
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Brain magnetic resonance images were obtained with a Discovery MR750 3.0T scanner (General Electric, Milwaukee, WI, USA), equipped with a 32-channel array head coil. Blood-oxygen level-dependent (BOLD) contrast images were acquired for the rs-EEG-fMRI and EEG-fMRI EC-EO conditions using an echo-planar reconstruction (spatial resolution = 4 × 4 × 4 mm3 voxels, TR = 2000 ms, TE = 40 ms). High resolution structural sagittal T1-weighted images (spoiled gradient-recalled sequence; resolution of 1 × 1 × 1 mm3 voxels; TR = 8.1 ms; and TE = 3.2 ms) were collected following the simultaneous EEG-fMRI recordings, after the EEG cap was removed from the participant’s head.
5
Multiecho fMRI Preprocessing Protocol
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Scanning was performed using a General Electric Discovery MR750 3.0-T scanner, with a 32-channel head coil. Scan acquisition parameters are described in SI Appendix, Supplementary Methods . fMRI data were preprocessed using AFNI (68 (link)) (RRID: SCR_005927) to reduce noise and facilitate across-subject comparisons. Preprocessing included both standard and multiecho preprocessing using multiecho independent components analysis (69 (link)) as described in SI Appendix, Supplementary Methods .
6
Multimodal Neuroimaging in Reward Processing
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Data were acquired using a GE Discovery MR750 3.0 T scanner with a standard adult-sized coil (Milwaukee, WI). A full-brain high-resolution T1 SPGR PROMO scan was acquired that is used in preprocessing (TR =7000 ms, TE =2900 ms, flip angle = 8°, FOV =25.6 cm, slice thickness =1 mm, 208 sagittal slices; matrix = 256 × 256). Before the MID task, a fieldmap was acquired using spin-echo EPI (TR =7400 ms, TE =80 ms, FOV =21.6 cm, 90 × 90 matrix) with opposite phase encoding polarity (A→P, P→A). Two functional T2*-weighted BOLD MID runs were acquired in the axial plane using a multiband EPI sequence (MB factor = 6) of 60 contiguous axial 2.4 mm slices (TR =800 ms, TE =30 ms, flip angle = 52°, FOV =21.6 cm, 90 × 90 matrix, volumes = 407).
7
3T MRI Protocol for Quantitative Imaging
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MR images were all acquired using a Discovery MR750 3.0 T scanner (GE Healthcare, Milwaukee, WI, U.S.) with an eight-channel phased array body coil for signal reception. Images were acquired by spin echo and T1-weighted 3D gradient recalled echo with a 2-point Dixon fat/water separation method (LAVA FLEX). In each study, a T2-FS sequence and a CET1 sequence were included. Other sequences such as T1-weighted fat-saturated images and general T1-weighted and T2-weighted images without fat saturation were excluded for analysis due to the retrospective data imperfection. Intravenous administration was gadodiamide injection (Omniscan®, GE Healthcare, Ireland) using a weight-based dosing protocol (0.1 mmol/L per kg body weight), and the injection rate was 2.5 mL/s. All sequence parameters are described in Table 2 . All MR data were retrieved from the picture archiving and communication system (PACS) of our institute and saved in the DICOM format for further analysis.
8
Diffusion MRI Acquisition Protocol
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Diffusion data were acquired using a GE Discovery MR750 3.0T scanner with a standard 8-channel head coil at Xijing Hospital. During scanning, all participants were instructed to keep their eyes open, let their minds wander, and stay awake.19 (link) Diffusion-weighted sequences with single-shot echo planar imaging aligned to the anterior-posterior commissural plane were acquired using the following parameters: field of view (FOV) = 282 mm × 282 mm, repetition time (TR)/echo time (TE) = 8000/89 ms, flip angle = 90°, slice thickness = 2.2 mm, and 62 continuous axial slices with no gap. The diffusion sensitizing gradients were applied along 64 non-linear directions (b = 1000 s/mm2), combined with an acquisition without diffusion weighting (b = 0 s/mm2).
9
Multimodal Neuroimaging Protocol for fMRI
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Data were acquired on a General Electric Discovery MR750 3.0T scanner, using a 32-channel phased-array head coil. Functional images were acquired using a BOLD-contrast sensitive multi-echo echo-planar sequence [Array Spatial Sensitivity Encoding Technique (ASSET) acceleration factor = 2, TEs = 12.5, 27.6, and 42.7 ms, TR = 2,200 ms, flip angle = 75°, 64 × 64 matrix, in-plane resolution = 3.2 mm × 3.2 mm]. Whole-brain EPI volumes (MR frames) of 33 interleaved, 3.5 mm-thick oblique slices were obtained every 2.2 s. Slices were manually aligned to the AC-PC axis. A high-resolution T1 structural image was also obtained for each subject (TE = 3.47 ms, TR = 2.53 s, TI = 900 ms, flip angle = 7°, 172 slices of 1 mm × 1 mm × 1 mm voxels).
Foam pillows were provided for all participants to help stabilize head position and scanner noise was attenuated using foam ear plugs and a noise-canceling headset. This headset was also used to communicate with the participant during their time in the scanner. Heart rate was recorded via a sensor placed on the left middle finger and a belt monitored respiration.
Foam pillows were provided for all participants to help stabilize head position and scanner noise was attenuated using foam ear plugs and a noise-canceling headset. This headset was also used to communicate with the participant during their time in the scanner. Heart rate was recorded via a sensor placed on the left middle finger and a belt monitored respiration.
10
3D High-Resolution Brain Imaging
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T1‐weighted images were acquired on a GE Discovery MR750 3.0T scanner with a 32‐channel, phased array head coil, using a three‐dimensional high‐resolution BRAVO sequence. The image acquisition parameters: matrix of 256 × 256, voxel size of 1.0 × 1.0 × 1.0 mm3, field of view of 256 × 256 mm, bandwidth of 41.67 kHz, TR:7.2 msec, TE:2.7 msec, Flip angle:12°, 176 slices.
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