Inveon pet system

Manufactured by Siemens

Sourced in Germany

The Inveon PET system is a preclinical Positron Emission Tomography (PET) imaging platform designed for small animal research. It provides high-resolution imaging capabilities for various applications in life sciences, including the study of disease models and the evaluation of novel therapeutic compounds.

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Lab products found in correlation

Wizard gamma counter, by PerkinElmer (1 mentions)

Close spelling variants of this product

Inveon preclinical small-animal PET/computerized tomography (CT) system Inveon PET/CT system Inveon small-animal PET/CT system Inveon micro-CT/SPECT/PET system Inveon Dedicated PET System Inveon preclinical PET/CT system Inveon PET/CT Multimodality System INVEON PET/CT imaging system Inveon Dedicated PET (dPET) System Inveon small-animal PET system

6 protocols using inveon pet system

Stereotaxic FDG-PET Imaging in Crows

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Immediately following the terminal rest period of the experimental
stimulation protocol, we hooded and removed the subject from its cage,
anesthetized it with five percent isoflurane in oxygen with a flow rate of
300–800 mL/min via a special nose cone manufactured from a 50-mL syringe
tube, and then positioned it in the scanner. We obtained high resolution FDG-PET
images using a Siemens Inveon PET system for 10 min, starting 25 min after FDG
injection (except for one subject, which was imaged after 27 min). Following
imaging, we executed a 13 min attenuation scan and then reconstructed using
vendor supplied 3D OSEM/MP algorithm with attenuation and scatter corrections
applied to the data. The image matrix was 128 × 28 × 159. We
stereotaxically aligned the PET images to the jungle crow (Corvus
macrorhynchos) brain atlas (Marzluff et al. 2012 (link); Izawa and Watanabe 2007). For consistent
stereotactic transformations of scans from the same subject, we estimated and
applied nine affine parameters to the images using algorithms for automated
human brain image analysis adapted for crow brains (NEUROSTAT, University of
Utah; Minoshima et al. 1992 (link)). We
estimated that aligned precision was one to two millimeters.

Swift K.N., Marzluff J.M., Templeton C.N., Shimizu T, & Cross D.J. (2020). Brain activity underlying American crow processing of encounters with dead conspecifics. Behavioural brain research, 385, 112546.

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In Vivo Brain [18F]-FDG PET Imaging in Rats

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Using a previously described methodology^{21 (link)}, approximately 0.2 MBq/g of [¹⁸F]-FDG were injected in the tail vein under short-term anesthesia by inhalation of an isoflurane-oxygen mixture (2%–1.5 v/v) in the SD- and KD-rats. Then, the rats were put in their home cage back, in a quiet environment. The brain [¹⁸F] FDG-PET was recorded 45 min later with an Inveon PET system (Siemens. Knoxville. TN. USA), under the same isoflurane-oxygen anesthesia and with a 30-min emission sequence followed by a 10-min transmission sequence with Co-57 providing an attenuation correction map. Their respiration was monitored and maintained constant throughout the experiment. As previously described^{21 (link)}, the brain [¹⁸F]-FDG PET images were reconstructed in kBq/ml using an OSEM-3D iterative method involving 4 iterations with 12 subsets and corrected for attenuation. The images were finally displayed with 0.26 × 0.26 × 0.80 mm³ voxels, reoriented and cropped to suppress most of the extracerebral signal.

Doyen M., Lambert C., Roeder E., Boutley H., Chen B., Pierson J., Verger A., Raffo E., Karcher G., Marie P.Y, & Maskali F. (2024). Assessment of a one-week ketogenic diet on brain glycolytic metabolism and on the status epilepticus stage of a lithium–pilocarpine rat model. Scientific Reports, 14, 5063.

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TAZ Knockdown in Mice: Metabolic Profiling

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Maintenance and animal experiments were performed according to the guidelines from the German Animal Welfare Act and approved by the Bayerisches Landesamt für Gesundheit und Lebensmittelsicherheit, Germany (AZ: 55.2.2–2535-804). Doxycycline (625 mg/kg) was administered as part of the standard rodent chow to WT C57BL/6N mice and transgenic (ROSA26H1/tetO-shRNA:TAZ) animals [1 (link), 6 (link), 73 (link)]. Doxycycline was withdrawn from female mice for 1 week before mating and during the mating period to avoid male infertility. Doxycycline treatment was resumed upon successful mating (copulatory plugs) and continued until the end of experiment at an age of 30- 50 weeks, unless indicated otherwise. The genotype of the pups was assessed by PCR, as described previously [1 (link)]. Mouse line and transgene induction were identical to our previous studies [6 (link)]. For analysis of in vivo metabolism, animals were fasted for 12 h. Radiotracers were administered via intraperitoneal (i.p.) injection of 7–15 MBq ¹⁸F-FDG, or via intravenous (i.v.) injection of 7–15 MBq ¹⁸F-FTOa, or 7–15 MBq ¹⁸F-FASu. 5 min prior analysis, anaesthesia was started, using 2% isoflurane. Static 30-min PET imaging (60–90 min) followed by postmortem organ tissue counting was performed using a Inveon PET System, Siemens Medical Solutions (Erlangen, Germany) and Wizard Gamma Counter, PerkinElmer (Waltham, MA).

Kutschka I., Bertero E., Wasmus C., Xiao K., Yang L., Chen X., Oshima Y., Fischer M., Erk M., Arslan B., Alhasan L., Grosser D., Ermer K.J., Nickel A., Kohlhaas M., Eberl H., Rebs S., Streckfuss-Bömeke K., Schmitz W., Rehling P., Thum T., Higuchi T., Rabinowitz J., Maack C, & Dudek J. (2023). Activation of the integrated stress response rewires cardiac metabolism in Barth syndrome. Basic Research in Cardiology, 118(1), 47.

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Small Animal 18F-FP-(+)-DTBZ PET Imaging

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The small animal ¹⁸F-FP-(+)-DTBZ PET imaging followed a previously published protocol [38 (link)], and all PET images were acquired on a preclinical Inveon PET system (Siemens Medical Solutions, Knoxville, TN, USA). Each mouse was subjected to a 20-min static scan under isoflurane anesthesia (1.5% in oxygen gas) 30 min after receiving a single bolus injection of ¹⁸F-FP-(+)-DTBZ (22.76 ± 0.45 MBq in 0.1 mL saline) through a tail vein.
All image data were processed and analysed using PMOD image analysis software (v. 3.2; PMOD Technologies, Zurich, Switzerland). Each image was normalised according to the corresponding ¹⁸F-FP-(+)-DTBZ PET mouse template [39 ] and coregistered to the PMOD built-in T2-weighted magnetic resonance imaging (MRI) template. The built-in volume of interests (VOIs) of the striatum and the cerebellum from the MRI template were applied to normalised PET images for quantification. The striatal specific uptake ratio (SUr) was calculated as [(uptake in striatum − uptake in cerebellum)/ (uptake in cerebellum)], where the cerebellum was used as the reference region [38 (link)].

Weng C.C., Chen Z.A., Chao K.T., Ee T.W., Lin K.J., Chan M.H., Hsiao I.T., Yen T.C., Kung M.P., Hsu C.H, & Wey S.P. (2017). Quantitative analysis of the therapeutic effect of magnolol on MPTP-induced mouse model of Parkinson’s disease using in vivo 18F-9-fluoropropyl-(+)-dihydrotetrabenazine PET imaging. PLoS ONE, 12(3), e0173503.

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Cerebral Glucose Metabolism Changes with Acupuncture

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Cerebral images were acquired using PET during the first and final acupuncture sessions on day 1 and day 30. After 24 h of fasting, blood glucose values were measured from tail bleeds by the glucose oxidase method (Glucose Kit, bioMerieux, normal standard 3.95±1.31 mmol/L) before the rats were sent for PET scanning at the PET-CT Centre of the Experimental Animals Center of the People’s Liberation Army (PLA) General Hospital. A tracer (fludeoxyglucose (18F)), ¹⁸F-FDG, synthesised with Mini Tracer accelerator, 1.5 mci/500 g dosage) was injected via the tail vein 3 min after the start of the first acupuncture treatment, which continued for the next 10 min post-injection. After the treatment, rats were anaesthetised with 5% isoflurane in 100% oxygen 5 min before the scan.
FDG-PET images were acquired using a Siemens Inveon PET system (Siemens Medical Solutions) with a radial spatial resolution of 1.4 mm full-width at half-maximum (FWHM) at the centre of the field of view (FOV). Images were subsequently reconstructed using a filtered back projection (FBP) algorithm on a 128×128×159 matrix, where the voxel size equals 1.46×1.46×0.79. All scans were saved in Analyse 7.5 format.
Imaging was repeated on day 30, after completion of the 20th acupuncture treatment. After scanning, the Y-maze test of spatial learning and memory was also repeated and the final TRT of each group was recorded.

Lai X., Ren J., Lu Y., Cui S., Chen J., Huang Y., Tang C., Shan B, & Nie B. (2015). Effects of acupuncture at HT7 on glucose metabolism in a rat model of Alzheimer's disease: an 18F-FDG-PET study. Acupuncture in Medicine, 34(3), 215-222.

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PET-CT Imaging of Glucose Metabolism in Acupuncture Treated Rats

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PET-CT scans were obtained at the animal molecular imaging platform of Sun Yat-sen Medical College. 18 Tail blood glucose was measured before PET-CT using the glucose oxidase method. After the acupuncture treatment, rats were intravenously injected with 18F-FDG (1.5 mCi/kg) and scanned on a Siemens Inveon PET system (Siemens, Germany). The FDG-PET images were acquired at fullradial spatial resolution with a 1.4 mm radius at the center of the field of view. Images were then reconstructed using a 128 × 128 × 159 matrix and a filtered back projection algorithm. All images were saved in Analyze 7.5 format.
Acupuncture in Medicine, 37 (2) After the evaluation of glucose metabolism, all rats were sacrificed by exsanguination following an intraperitoneal dose of 45 mg/kg sodium pentobarbital. Asystole was used as the standard for confirmation of death. All efforts were made to minimize the number of animals used and their suffering.

Li J., Peng C., Lai D., He K., Wang Y., Zhang G., Wu Y., Nie B., Shan B., Tang C, & Lai X. (2019). Changes in cerebral glucose metabolism after acupuncture at KI3 in spontaneously hypertensive rats: a positron emission tomography study. Acupuncture in medicine : journal of the British Medical Acupuncture Society, 37(2).

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