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Darunavir

Manufactured by MedChemExpress
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Darunavir is a laboratory product that functions as a protease inhibitor. It is used in scientific research and development.

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Lab products found in correlation

Dolutegravir, by MedChemExpress (3 mentions) Ritonavir, by MedChemExpress (3 mentions) Ledipasvir, by MedChemExpress (2 mentions) Daclatasvir, by MedChemExpress (2 mentions) Elbasvir, by MedChemExpress (2 mentions) Asunaprevir, by MedChemExpress (2 mentions) Sofosbuvir, by MedChemExpress (2 mentions) Grazoprevir, by MedChemExpress (2 mentions) Lopinavir, by MedChemExpress (2 mentions) Atazanavir sulfate, by MedChemExpress (2 mentions) Simeprevir, by MedChemExpress (2 mentions) Aβ1 40, by Fujifilm (1 mentions) Abacavir, by Merck Group (1 mentions) Elvitegravir, by MedChemExpress (1 mentions) Aβ1 42 elisa kits, by Fujifilm (1 mentions) Nelfinavir, by Merck Group (1 mentions) Efavirenz, by Merck Group (1 mentions) Lamivudine, by Merck Group (1 mentions) Nevirapine, by Merck Group (1 mentions) Ritonavir, by Merck Group (1 mentions)

5 protocols using darunavir

1

Evaluating Anti-HIV and Anti-Alzheimer's Compounds

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Zidovudine, abacavir, lamivudine, efavirenz, nevirapine, ritonavir, and nelfinavir were obtained from Sigma. Emtricitabine, tenofovir disoproxil fumarate, darunavir, dolutegravir and elvitegravir were obtained from MedChem Express. LysoSensor (DN160) was obtained from Fisher Thermo Scientific. Aβ1–40 and Aβ1–42 ELISA kits were obtained from Wako. ML-SA1 was obtained from Tocris Bioscience.
Hui L., Ye Y., Soliman M.L., Lakpa K.L., Miller N.M., Afghah Z., Geiger J.D, & Chen X. (2019). Antiretroviral drugs promote amyloidogenesis by de-acidifying endolysosomes. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 16(1), 159-168.
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2

High-Throughput ABCB1 Inhibition Assay

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[3H]-digoxin was purchased from Moravek Biochemicals (Brea, CA, USA). Abacavir, atazanavir, etravirine, lopinavir, maraviroc, rilpivirine, ritonavir, saquinavir, tenofovir DF, and zidovudine were obtained from the NIH AIDS Reagent Program. Asunaprevir, daclatasvir, darunavir, dolutegravir, elbasvir, grazoprevir, ledipasvir, sofosbuvir, and velpatasvir were acquired from MedChemExpress LLC (Middlesex County, NJ, USA). The model ABCB1 inhibitor CP100356 [76 (link)], the ATP bioluminescence assay kit, DMSO, Dulbecco’s Modified Eagle Medium, ethanol (EtOH), fetal bovine serum, nonessential amino acid solution, and penicillin–streptomycin solutions were purchased from Sigma-Aldrich (St. Louis, MO, USA). Hanks’ balanced salt solution, William’s medium E containing L-glutamine (WME), and the bicinchoninic acid protein assay kit were obtained from Thermo Fisher Scientific (Waltham, MA, USA). Krebs–Henseleit buffer was prepared as described by de Graaf et al. [31 (link)]. All other reagents were of analytical grade.
Huličiak M., Vokřál I., Holas O., Martinec O., Štaud F, & Červený L. (2022). Evaluation of the Potency of Anti-HIV and Anti-HCV Drugs to Inhibit P-Glycoprotein Mediated Efflux of Digoxin in Caco-2 Cell Line and Human Precision-Cut Intestinal Slices. Pharmaceuticals, 15(2), 242.
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3

Antiretroviral Drugs' Effects on Cells

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Atazanavir, ritonavir and darunavir were from Medchem Express. Cells were treated in appropriate media for 14 days with DMSO (control) or drugs dissolved in DMSO at 10–20 μM (Cmax plasma concentrations) according to the literature (Auclair et al., 2014 (link)). Cells were then washed with PBS and placed in serum‐free DMEM. Cells and conditioned media were collected after 24 h for analyses.
Kuehnemann C., Hughes J.B., Desprez P., Melov S., Wiley C.D, & Campisi J. (2022). Antiretroviral protease inhibitors induce features of cellular senescence that are reversible upon drug removal. Aging Cell, 22(1), e13750.
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4

Antiviral Drug Screening Protocol

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Acetaminophen (catalog number HY-66005), arbidol hydrochloride (HY-14904A), aspirin (HY-14654), atazanavir sulfate (HY-17367A), baloxavir marboxil (HY-109025), daclatasvir (HY-10466), darunavir (HY-17040), dolutegravir (HY-13238), efavirenz (HY-10572), elbasvir (HY-15789), etravirine (HY-90005), galidesivir (BCX4430, HY-18649A), ganciclovir (HY-13637), glecaprevir (HY-17634), hydroxychloroquine (HY-B1370), indomethacin (HY-14397), ledipasvir (HY-15602), lopinavir (HY-14588), losartan (HY-17512), nafamostat mesylate (HY-B0190A), nitazoxanide (HY-B0217), ombitasvir (HY-13997), oseltamivir (HY-13318), penciclovir (HY-17424), perindopril salt (HY-B0130A), raltegravir (HY-10353), remdesivir (GS-5734, HY-104077), rilpivirine (HY-10574), ritonavir (HY-90001), simeprevir (HY-10241), sofosbuvir (HY-15005), and β-d-N4-hydroxycytidine (HY-125033) were purchased from MedChemExpress (Monmouth Junction, NJ, United States). Amodiaquin dihydrochloride dihydrate (A2799), artesunate (A3731), chloroquine phosphate (PHR1258), mefloquine hydrochloride (PHR1705), peramivir trihydrate (SML2486), ribavirin (R9644), teicoplanin (T0578), and toremifene citrate salt (T7204) were purchased from Sigma-Aldrich (St, Louis, Missouri, United States). Favipiravir (T-705) was provided by the Toyama Chemical Co., Ltd. (Japan). The drug solutions were filtered through a 0.22 μM membrane and were stored at −80°C.
Bang M.S., Kim C.M., Kim D.M, & Yun N.R. (2022). Effective Drugs Against Severe Fever With Thrombocytopenia Syndrome Virus in an in vitro Model. Frontiers in Medicine, 9, 839215.
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5

Evaluation of Protease and Proteasome Inhibitors

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Saquinavir (Cat no. HY-17007), Ritonavir (Cat no. HY-90001), Indinavir (Cat no. HY-B0689), Nelfinavir Mesylate (Cat no. HY-15287A), Amprenavir (Cat no. HY-17430), Lopinavir (Cat no. HY-14588), Atazanavir sulfate (Cat no. HY-17367A), Fosamprenavir (Cat no. HY-78726), Tipranavir (Cat no. HY-15148), Darunavir (Cat no. HY-17040), Boceprevir (Cat no. HY-10237), Telaprevir (Cat no. HY-10235), Simeprevir (Cat no. HY-10241), Asunaprevir (Cat no. HY-14434), Grazoprevir (Cat no. HY-15298), Carfilzomib (Cat no. HY-10455), and Bortezomib (Cat no. HY-10227) were purchased from MedChemExpress. GC376 (Cat no. T5188) were purchased from TargetMol.
Fu L., Ye F., Feng Y., Yu F., Wang Q., Wu Y., Zhao C., Sun H., Huang B., Niu P., Song H., Shi Y., Li X., Tan W., Qi J, & Gao G.F. (2020). Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease. Nature Communications, 11, 4417.
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