Realtime hiv 1 test

Participants were 120 PLWH and 94 persons without HIV, aged 36 to 65, from the five-year Multi-Dimensional Successful Aging among HIV-Infected Adults study. Baseline data were examined in this study. The University’s Institutional Review Board approved this study, and all participants provided written, informed consent. In order to enroll a representative cohort of participants, exclusion criteria were minimal: 1) diagnosis of a psychotic disorder or mood disorder with psychotic features (asked at screening visit); 2) presence of a neurological condition (beyond HIV infection) known to impact cognitive functioning (e.g., Alzheimer’s disease, stroke, traumatic brain injury); 3) positive urine toxicology on the day of testing. An HIV/HCV finger stick point of care test (Abbott RealTime HIV-1 test, Abbott Laboratories, Illinois, USA) was used to test all participants for HIV infection. Of the participants who reported they were HIV- at screening, none tested positive for HIV nor HCV.

Data were collected as part of the NIMH-funded Multi-Dimensional
Successful Aging among HIV Infected Adults Study at University of California,
San Diego (UCSD), which is described in an earlier publication.³³ Briefly, the study recruited
community-dwelling PLWH and HIV-uninfected adults 35 to 65 years old. The
exclusion criteria were: 1) history of psychotic disorder or a mood disorder
with psychotic features; 2) the presence of a neurological condition not related
to HIV infection and known to affect cognitive functioning, such as
Alzheimer’s disease, stroke or traumatic brain injury; and 3) having a
positive urine toxicology test for drugs of abuse during the baseline visit.
During the screening, participants with unknown HIV status were tested with the
HIV/HCV finger stick point of care test (Abbott Real-time HIV-1 test, Abbott
Laboratories, Illinois, USA). Participants were compensated for participation.
The UCSD Institutional Review Board approved the study and participants provided
written informed consent to participate. The sample for the present
cross-sectional analyses is based on biomedical and psychosocial data from the
baseline visit and includes 65 PLWH and 62 HIV-uninfected participants who were
administered frailty assessment.¹

Participants were 90 HIV-positive and 94 HIV-negative persons, with balanced recruiting in each age decade (36–45, 46–55, 56–65), from the five-year Multi-Dimensional Successful Aging among HIV-Infected Adults study conducted at the University of California, San Diego (UCSD).^{16 (link)} Only baseline data were included in this analysis. The study received approval from the UCSD Institutional Review Board. Participants provided written, informed consent. Exclusion criteria for the parent study were diagnosis of a psychotic disorder and presence of a neurological condition known to impact cognitive functioning (e.g., stroke). Additional exclusion criteria for current analyses included being off ART, having detectable HIV viral load (>50 copies/ml), and meeting criteria for a current substance use disorder. HIV infection was screened via a fingerstick test (Medmira, Nova Scotia, Canada) and confirmed with an Abbott RealTime HIV-1 test (Abbott Laboratories, Illinois, USA) or by submitting specimens to a Clinical Laboratory Improvement Amendments (CLIA)-certified laboratory (ARUP Laboratories, Utah, USA) for HIV-1 viral load quantitation.