DWI data were acquired with a Siemens 3 tesla Magnetom Skyra MRI scanner at the Clinical Research and Imaging Centre (CRiCBristol), Bristol, UK. Subjects were placed supine within the 32-channel receive only head-coil by an experienced radiographer, and head movement minimised by means of memory-foam padding. Children wore earplugs and were able to watch a film. A multiband echo-planar imaging sequence was used with the following parameters: TE = 70 ms; TR = 3150 ms; field of view 192 × 192 mm; 60 slices; 2.0 mm isotropic voxels; phase encoding in the anterior-posterior direction, in-plane acceleration factor = 2 (Griswold et al., 2002 (link)), through-plane multi-band factor = 2 (Setsompop et al., 2012 (link)a, b; Moeller et al., 2010 (link)). For the purpose of data averaging and eddy-current distortion correction, two sets of diffusion weighted images were acquired with b = 1,000 s mm-2 in 60 diffusion directions, equally distributed according to an electrostatic repulsion model, as well as 8 interspersed b = 0 images, with one data set acquired with positive phase encoding steps, then repeated with negative steps (so-called, “blip-up”, “blip-down”), giving a total of 136 images.
3 tesla magnetom skyra
Manufactured by Siemens
Sourced in Germany, United Kingdom
The 3 tesla Magnetom Skyra is a magnetic resonance imaging (MRI) system manufactured by Siemens. It utilizes a 3 tesla superconducting magnet to generate a strong magnetic field for high-resolution imaging of the human body.
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7 protocols using 3 tesla magnetom skyra
1
Multiband DWI Acquisition Protocol
2
Quantifying Muscle Mass and Fat Content
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Magnetic resonance imaging examinations were performed in supine position on a 3‐Tesla Magnetom Skyra (Siemens Healthineers, Erlangen, Germany) using an 18‐channel body surface coil in combination with a table‐mounted spine matrix coil. The complete imaging protocol and technical specificities have been described in detail elsewhere.8 For muscle segmentation, a T2*‐corrected, multi‐echo 3D‐gradient‐echo Dixon‐based sequence (multi‐echo Dixon) of the upper abdomen providing a coverage of approximately 40 to 50 cm with the following parameters was used (time to repetition (TR): 8.90 ms; time to echo (TEs): 1.23, 2.46, 3.69, 4.92, 6.15, and 7.38 ms; flip angle 4°, readout echo bandwidth 1080 Hz/pixel, matrix 256 × 256, slice thickness 4 mm). Data were acquired during a single breath‐hold of 15 s. The post‐processing algorithm using the Software MR LiverLab (Version VD13, Siemens Healthineers, Cary, USA) automatically calculated proton‐density fat‐fraction maps as DICOM‐files, which were used to simultaneously assess muscle mass and fat content.
3
Multiband DWI Acquisition Protocol
4
Neuroimaging of Prenatal Alcohol Exposure
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Imaging was conducted at the Cape Town Universities Brain Imaging Centre (CUBIC). A portion of participants (n = 13; n = 11 PAE, n = 2 Controls) received scans on a Siemens MAGNETOM 3‐Tesla Allegra MRI system (Erlangen, Germany) at CUBIC Tygerberg Hospital. The remaining participants received scans on a Siemens MAGNETOM 3‐Tesla Skyra (Erlangen, Germany) whole body scanner at CUBIC Groote Schuur Hospital. A 32‐channel head coil was used. 3D sagittal T1‐weighted MEMPRAGE (Multi‐Echo Magnetization Prepared Rapid Acquisition Gradient Echo) images were obtained. The Siemens MAGNETOM 3‐Tesla Allegra imaging parameters were as follows: repetition time (TR) = 2530 ms; echo time (TE) = 1.53, 3.21, 4.89, 6.57 ms; flip angle = 7.0°; voxel size 1.0 × 1.0 × 1.0 mm; inversion time (TI) = 1100 ms; field of view (FOV) = 160/160/128 mm; matrix =160 × 160, 128 slices; scan time: 6 min 45 s. The Siemens MAGNETOM 3‐Tesla Skyra imaging parameters were as follows: TR = 2530 ms; TE = 1.69, 3.54, 5.39, 7.24 ms; flip angle = 7.0°; voxel size 1.0 × 1.0 × 1.0 mm; TI = 1100 ms; FOV = 224/224/176 mm; matrix = 256 × 256, 176 slices; scan time: 5 min 21 s.
5
Multimodal MRI Neuroimaging Protocol
6
COVID-19 Brain MRI Imaging Protocol
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From March 2020 to March 2021, 481 brain MRI studies were performed on a Siemens MAGNETOM Skyra 3 Tesla resonator (SIEMENS S/N 145452, Software NUMARIS/4, Version syngo MR E11, Mexico City) with at least the following sequences: axial and coronal T2-weighted image (T2WI), axial T1-weighted image (T1WI), sagittal and coronal T1-fluid-attenuated inversion recovery (FLAIR), axial T2-FLAIR, axial diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC) map, axial gradient echo sequences (GRE), and three-dimensional time of light (3D TOF). Other sequences such as susceptibility-weighted images (SWI) and post-contrast T1-weighted sequences were acquired at the request of the radiologist.
A clinical-radiological correlation was performed, and SARS-CoV-2-positive patients (confirmed by RT-PCR test) were selected. Image analysis was performed by three radiology specialists, and case follow-up was performed by an imaging resident. In addition, published scientific literature was reviewed.
A clinical-radiological correlation was performed, and SARS-CoV-2-positive patients (confirmed by RT-PCR test) were selected. Image analysis was performed by three radiology specialists, and case follow-up was performed by an imaging resident. In addition, published scientific literature was reviewed.
7
3T MRI Infant Brain Acquisition
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Scans were performed on a Magnetom Trio Tim 3 Tesla or on Magnetom Skyra 3 Tesla (Siemens Medical, Erlangen, Germany) with a 32-channel adult head coil. Multi-echo volumetric magnetization prepared rapid gradient echo (MPRAGE) sequences (van der Kouwe et al., 2008 (link)) with volume navigators (vNav) for motion correction (Tisdall et al., 2012 (link)) were obtained in the sagittal plane with an average image resolution of 1 mm isotropic, higher than the typical clinical infant acquisition standard. A full list of acquisition parameters is described in detail in Table 2 . The subjects were imaged under sedation or during natural sleep. Images were assessed for quality and scans considered not suitable for segmentation, due to degradation by motion or other artifacts, were discarded.
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