U18666A, Methyl-β-cyclodextrin (MbCD), Ro 48-8071, AY-9944, Amorolfine, Simvastatin, Clomiphene, and Alendronate were purchased from Sigma Aldrich (USA). Lovastatin, Fluvastatin, and Itraconazole were purchased from Wako Pure Chemical (Japan). Vorinostat was purchased from Cayman Chemical (USA). U18666A and MbCD were dissolved in water as 10 mM (U18666A) and 1 M (MbCD) stock, respectively. Other compounds were dissolved in dimethyl sulfoxide (DMSO) as 10 mM stock. On the day of the experiments, these compounds were diluted to the desired concentrations in maintenance medium.
Clomiphene
Manufactured by Merck Group
Sourced in United States
Clomiphene is a pharmaceutical product manufactured by Merck Group. It is a type of lab equipment used for various research and scientific applications. The core function of Clomiphene is to facilitate specific laboratory procedures and experiments.
Automatically generated - may contain errors
Lab products found in correlation
Itraconazole, by Fujifilm (1 mentions)
Amorolfine, by Merck Group (1 mentions)
Simvastatin, by Merck Group (1 mentions)
Alendronate, by Merck Group (1 mentions)
Vorinostat, by Cayman Chemical (1 mentions)
Ro 48 8071, by Merck Group (1 mentions)
Lovastatin, by Fujifilm (1 mentions)
Fluvastatin, by Fujifilm (1 mentions)
Methyl β cyclodextrin, by Merck Group (1 mentions)
Ay9944, by Merck Group (1 mentions)
Diagnostic kit, by Merck Group (1 mentions)
Alloxan, by Merck Group (1 mentions)
Vincamine, by Merck Group (1 mentions)
Mitoxantrone, by Santa Cruz Biotechnology (1 mentions)
Neomycin b, by Merck Group (1 mentions)
Ciprofloxacin, by Merck Group (1 mentions)
3 protocols using clomiphene
1
Chemical Compound Preparation Protocol
2
Evaluation of Clomiphene and Vincamine
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Clomiphene and diagnostic kits were purchased from Sigma, Germany. Vincamine and alloxan were purchased from Sigma, St.Lous. The other compounds employed in the research were analytical grade and originate from well-known sources.
3
Screening FDA-approved drugs for antiviral activity
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The primary fluorescence anisotropy screen used a collection of 1,120 FDAapproved drugs dissolved in DMSO at a concentration of 5 mM, acquired from Prestwick Chemical (Illkirch France). According to the manufacturer, the compounds were selected for their high chemical and pharmacological diversity and accessible information on bioavailability and safety in humans. For subsequent experiments, neomycin B, clomiphene and ciprofloxacin were obtained from Sigma-Aldrich (St. Louis USA), neamine from Toronto Research (Toronto Canada), and cyproheptadine and mitoxantrone from Santa Cruz Biotechnology (Dallas USA). Additional amounts of other compounds were obtained from the Prestwick stocks. The antiretroviral drugs zidovudine and nelfinavir used as positive controls in the anti-HIV activity assay were obtained through the AIDS Reagent Program (NIAID, NIH USA).
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