Fasted and anesthetized (2% isoflurane) animals were tail vein injected with 300 µCi[18F]FDG (IBA Molecular, Sterling, VA). After 60 minutes of FDG uptake, PET/CT images were acquired in the Inveon Preclinical System (Siemens Healthcare, PA) without attenuation correction. Images were processed using manufacturer recommended calibration procedures and a phantom of known volume and activity acquired prior to the study. OSEM3D-MAP reconstructions used Inveon Acquisition Workplace 1.5 for region-of-interest (ROI) analysis in the Inveon Research Workplace 4.1. The percent injected dose/gram of tissue (%ID/g) was calculated after decay corrections with the formula, %ID/gm = Ct/ID × 100, where Ct is the concentration of radiotracer in the tissue obtained from the PET images after ROI analysis.
Inveon preclinical system
Manufactured by Siemens
The Inveon Preclinical System is a modular, multi-modal imaging platform designed for small-animal research. It integrates various imaging technologies, including positron emission tomography (PET), single-photon emission computed tomography (SPECT), and computed tomography (CT), within a single system. The Inveon Preclinical System enables researchers to perform non-invasive, longitudinal studies on small animals, such as rodents, to investigate a wide range of biological and pharmacological processes.
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Lab products found in correlation
2 protocols using inveon preclinical system
1
PET/CT Imaging of Glucose Metabolism
2
PET/CT Imaging Protocol for Quantifying In Vivo Biodistribution
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For positron emission tomography/computed tomography (PET/CT) imaging animals were fasted, anesthetized (2% isoflurane in oxygen), and injected intravenous (iv) with 300 µCi [18F]-FDG (fluorodeoxyglucose) from IBA Molecular (Sterling, VA). After 60 min of FDG uptake, animals were positioned in the Inveon Preclinical System (Siemens Healthcare, Malvern, PA), and PET/CT images were acquired for 10 min with no attenuation correction. The PET images were processed using manufacturer recommended calibration procedures and a phantom of known volume and activity acquired prior to the study. OSEM3D-MAP reconstructions were done using Inveon Acquisition Workplace 1.5 and were used for region-of-interest analysis in the Inveon Research Workplace 4.1. The percent injected dose/gram of tissue (%ID/g) values were calculated after appropriate decay corrections using the formula, %ID/g = Ct/ID × 100, where Ct is the concentration of radiotracer in the tissue (MBq/cc), obtained from the PET mages after region-of-interest analysis.
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