Midecamycin

Manufactured by MedChemExpress

Sourced in United States

Midecamycin is a macrolide antibiotic produced by the bacterium Streptomyces mycarofaciens. It functions as a protein synthesis inhibitor, binding to the 50S subunit of the bacterial ribosome and preventing the formation of the peptide bond during translation.

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3 protocols using midecamycin

Antiviral Compound Screening Protocol

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Carrimycin was provided by Shenyang Tonglian Group Co., Ltd. (Shenyang, China). Clarithromycin, midecamycin, erythromycin, roxithromycin, acetylspiramycin, azithromycin, clindamycin, remdesivir (RDV), and ammonium chloride (NH4Cl) were purchased from MedChemExpress (Monmouth Junction, NJ, USA). Ribavirin (RBV) and chloroquine (CQ) were purchased from Sigma–Aldrich (St. Louis, MO, USA).

Yan H., Sun J., Wang K., Wang H., Wu S., Bao L., He W., Wang D., Zhu A., Zhang T., Gao R., Dong B., Li J., Yang L., Zhong M., Lv Q., Qin F., Zhuang Z., Huang X., Yang X., Li Y., Che Y, & Jiang J. (2021). Repurposing carrimycin as an antiviral agent against human coronaviruses, including the currently pandemic SARS-CoV-2. Acta Pharmaceutica Sinica. B, 11(9), 2850-2858.

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Antiviral Screening of Small Molecules

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Human cervix adenocarcinoma (Hela), adenocarcinomic human alveolar basal epithelial cells (A549), human embryonic kidney cells (HEK293T) and human colon adenocarcinoma cell (Caco2) were obtained from American Type Culture Collection and maintained in complete DMEM medium (containing 2 mmol/L l‐Glutamine, 10% foetal bovine serum (Thermo Fisher Scientific), 100 μg/mL streptomycin and 100 U/mL penicillin) at 37°C with 5% CO₂ incubation. The interferon receptor knockout (IFNAR1 KO) HEK293T cells and retinoic acid‐inducible gene‐I (RIG‐I) KO HEK 293T cells were kept in our laboratory. The influenza virus strains used in this study were A/WSN/33(H1N1) (WSN), which was kept in our laboratory. The IAV‐luc (PR8) strain was a gift from Prof. Ling Chen (Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences). AZ and erythromycin were obtained from BBI Life Sciences. Ribavirin was obtained from Solarbio. Oseltamivir, midecamycin, spiramycin, acetylspiramycin, clarithromycin, dirithromycin, tamoxifen, fluvastatin, fluoxetine and clemastine were obtained from MedChemExpress. Amiodarone, amantadine, roxithromycin, delphinidin and bafilomycin A1 were obtained from Sigma. Chloroquine (CQ) and amlodipine (Norvasc) were obtained from Sangon Biotech.

Du X., Zuo X., Meng F., Han C., Ouyang W., Han Y., Gu Y., Zhao X., Xu F, & Qin F.X. (2020). Direct inhibitory effect on viral entry of influenza A and SARS‐CoV‐2 viruses by azithromycin. Cell Proliferation, 54(1), e12953.

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Rifamycin Compound Library Evaluation

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The 10 compounds in rifamycin
class used in this study were kindly provided by the Korea Chemical
Bank (www.chembank.org)
of the Korea Research Institute of Chemical Technology (Table S27). Rifamycin S (S4425), dirithromycin
(S4213), gamithromycin (S5328), spiramycin (S5744), kitasamycin (S3645),
acetylspiramycin (S3618), and josamycin (S4421) were purchased from
Selleckchem. Telithromycin (HYA0062), erythromycin ethylsuccinate
(HYB0957), tylosin (HYB0519A), midecamycin (HYB1908), tilmicosin (HYB0905),
tulathromycin A (HY15662), cadazolid (HY100436), radezolid (HY14800),
delplazolid (HY100180), lefamulin (HY16908A), pleuromutilin (HYN2301),
azamulin (HYW019847), valnemulin (HYB0027), chlortetracycline (HYB1327A),
demeclocycline (HY121268), eravacycline (HY16980), rolitetracycline
(HY18257), minocycline (HY17412A), meclocycline (HYB1366), omadacycline
(HY14865), and sarecycline (HY13858A) were purchased from MedChemExpress.
Troleandomycin (ab141568) was purchased from Abchem. Eperezolid (B3390)
was purchased from APExBIO. BODIPYTR Cadeverine (D6251) was purchased
from Invitrogen. Other compounds and E. coli O128:B12
LPS were purchased from Sigma-Aldrich.

Choi Y., Choe H.W., Kook M., Choo S., Park T.W., Bae S., Kim H., Yang J., Jeong W.S., Yu J., Lee K.R., Kim Y.S, & Yu J. (2023). Proline-Hinged α-Helical Peptides Sensitize Gram-Positive Antibiotics, Expanding Their Physicochemical Properties to Be Used as Gram-Negative Antibiotics. Journal of Medicinal Chemistry, 67(3), 1825-1842.

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