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2 protocols using star cap 1500

1

Formulation Development of Atorvastatin Calcium

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Atorvastatin calcium was purchased from Evershine Chemical Company (Hangzhou, China), Plasdone S630 and Polyplasdone XL10 were received from ISP Corporation (Covington, USA), Starch 1500 and Star Cap 1500 were received from Colorcon (Kent, UK), Polyox N10 was received from Dow Chemical Company (Edegem, Belgium), Ac-Di-Sol was received from FMC Corporation (Philadelphia, USA). Silicified microcrystalline cellulose (Prosolv® SMCC) was received from JRS Pharma (Slough, UK). Sodium stearyl fumarate (Lubripharm®) was received from SPI Pharma (Septemes-Les Vallons, France). Nicotinamide, Tween 80, pullulans, sodium dodecyl sulphate (SDS), maltodextrin, Poloxamer F68 and Span 80 were purchased from Sigma Aldrich (Dorset, UK). All other chemicals used were of analytical grade and purchased from Fisher Scientific Ltd (Loughborough, UK).
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2

Levothyroxine Sodium Salt Hydrate Formulation

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Levothyroxine sodium salt hydrate (LTSS, purity >99%, Acros Organics, Geel, Belgium, lot A0141090, CAS 25416-65-3) is a commercial product and was used without a priori purification. The producer of LTSS mentions solely that the product is hydrated, without providing the exact water content. This content was previously established in our previous study [15 (link)] and confirmed by the current obtained experimental data, as shown in Section 3.2.
As excipients, starch (StarCap 1500, Colorcon, Harleysville, USA), lactose anhydrous (Sigma Aldrich, Darmstadt, Germany), D-mannitol (Sigma Aldrich, Darmstadt, Germany), D-sorbitol (Fisher Scientific, Loughborough, UK), gelatin (Merck, Darmstadt, Germany), calcium lactate pentahydrate (CaLact, Sigma Aldrich, Darmstadt, Germany), magnesium stearate (Mosselman, Mons, Belgium), methyl 2-hydroxyethyl cellulose (Tylose, Sigma Aldrich, Darmstadt, Germany), colloidal SiO2 (Aerosil 200, Evonik Degussa, Essen, Germany) and talc (Imerys Talc, Malanaggio, Italy) were selected. All the excipients were used as received, without further purification. For all compounds, the producers declared that they are suitable for use as excipients.
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