6 mam

Manufactured by Lipomed

Sourced in Switzerland

6-MAM is a laboratory standard used for analytical purposes. It serves as a reference material for the identification and quantification of 6-Monoacetylmorphine, a metabolite of heroin, in various samples and matrices.

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Lab products found in correlation

Codeine, by Lipomed (3 mentions) Morphine, by Lipomed (3 mentions) Ammonium formate, by Merck Group (2 mentions) Morphine d3, by Lipomed (2 mentions) Formic acid, by BD (1 mentions) Ammonium hydroxide, by BD (1 mentions) Ammonium carbonate, by BD (1 mentions) Heroin hydrochloride, by Lipomed (1 mentions) 6 mam d3, by Lipomed (1 mentions) Formic acid, by Merck Group (1 mentions) Methamphetamine, by Lipomed (1 mentions) Amphetamine, by Lipomed (1 mentions)

Close spelling variants of this product

6-MAM-d3 (2 citations)

4 protocols using 6 mam

Quantitative Analysis of Opioids

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All the solvents used in this study were high-performance liquid chromatography (HPLC) grade and were purchased from BDH (Poole, UK). Ammonium formate was obtained from Sigma Aldrich (Steinheim, Germany). Morphine, 6-MAM, codeine, 6-AC, and their corresponding internal standards were purchased from Lipomed (Arlesheim, Switzerland). SPE cartridges (Clean Screen^®, CSDAU203) were obtained from United Chemical Technologies (Bristol, PA, USA). Stomach wall tissues were homogenized using Stomacher^® 400 and Stomacher 80 bags (dimensions: 101 × 152 mm with filter) purchased from Seward limited company (West Sussex, UK).

Al-Asmari A.I., Alharbi H, & Zughaibi T.A. (2022). Post-Mortem Analysis of Heroin Biomarkers, Morphine and Codeine in Stomach Wall Tissue in Heroin-Related Deaths. Toxics, 10(8), 473.

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Quantification of Opioid Compounds

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Morphine, Morphine-d3, 6-MAM, 6-monoacetylMorphine-d3 (6-MAM-d3), codeine, codeine-d3, and 6-AC were purchased from Lipomed (Arlesheim, Switzerland). Methanol (HPLC grade), acetonitrile (HPLC grade), ammonium carbonate, formic acid, and ammonium hydroxide were obtained from BDH (Poole, UK). Ammonium formate was obtained from Sigma-Aldrich (Steinheim, Germany). Clean Screen^® solid phase extraction (SPE) cartridges (CSDAU203) were obtained from United Chemical Technologies (Bristol, PA, USA).

Al-Asmari A.I., Alharbi H., Al-Zahrani A.E, & Zughaibi T.A. (2023). Heroin-Related Fatalities in Jeddah, Saudi Arabia, between 2008 and 2018. Toxics, 11(3), 248.

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Analytical Method for Opioid Compounds

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Heroin hydrochloride, heroin-d₃, 6-MAM, 6-MAM-d₃, 6-MAM-d₆, morphine-d₃, M6G, M6G-d₃, M3G, and M3G-d₃ were obtained from Lipomed (Lipomed GmbH, Arlsheim, Switzerland); morphine from NMD (NMD Grossisthandel AS, Oslo, Norway); and morphine-d₆ from Toronto Research Chemicals Inc. (Toronto, Ontario, Canada). Standard compounds were stored according to supplier recommendations. HPLC-grade methanol and acetonitrile were purchased from Labscan Ltd. (Poch SA, Gliwice, Poland); analytical grade ammonium formate and formic acid from Merck (Whitehouse Station, NJ, USA). All water used was provided by a MilliQ A10 purification system (Merck, Darmstadt, Germany). Stock and working solutions were prepared as described previously [11 (link)].

Gottås A., Arnestad M., Halvorsen P.S., Bachs L.C, & Høiseth G. (2016). Pharmacokinetics of heroin and its metabolites in vitreous humor and blood in a living pig model. Forensic Toxicology, 34(2), 277-285.

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Quantification of Drug Concentrations

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Amphetamine, methAmphetamine, MDMA, MDEA, MDA, morphine, codeine, 6-MAM, cocaine and BE (Lipomed, Weil am Rhein, Germany) were dissolved in a solution of 0.9 % NaCl (B. Braun, Melsungen, Germany) and diluted. The mouth rinse solution in study A had a concentration of 1.0 μg/ml. The incubation drug solution in study B had a concentration of 10 μg/ml.

Riedel A., Neukamm M.A., Klima M., Henkel K., Auwärter V, & Altenburger M.J. (2023). Drugs in dental biofilm and enamel – A pilot study. Heliyon, 10(1), e23177.

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