After the injection of 131I-CLR1404, planar whole-body images at multiple time points were acquired on a dual-head scanner (Infinia Hawkeye, General Electric) using a scan speed of 10 cm/s, 256 × 1024 matrix, peak set at 364 keV ± 15% and scatter peaks of 312 keV ± 15% and 424 keV ± 15%, high energy all-purpose collimator, and display bone dual density. SPECT/CT images of specific regions of interest were acquired at multiple time points on a SPECT/CT scanner (Infinia Hawkeye, General Electric) using 128 × 128 matrix, 120 projections, 3° per stop, 30 s per stop, with peak set at 364 ± 15% and scatter peaks of 312 ± 15% and 424 ± 15%. The CT settings are helical using a pitch of 1.9, interval 4.42 mm, voltage 140 kV, current 2.5 mA, matrix 512 × 512, filter soft, and pixel 1.10 mm. Processing was performed with Volumetrix MI.
Infinia hawkeye
Manufactured by GE Healthcare
Sourced in United States
The Infinia Hawkeye is a state-of-the-art medical imaging system designed for nuclear medicine applications. It combines a high-performance gamma camera with a low-dose computed tomography (CT) scanner, enabling healthcare professionals to acquire both functional and anatomical data during a single patient examination. The Infinia Hawkeye provides clinicians with comprehensive information to support accurate diagnosis and effective treatment planning.
Automatically generated - may contain errors
Lab products found in correlation
Xeleris workstation, by GE Healthcare (4 mentions)
Discovery 670 gamma camera, by GE Healthcare (2 mentions)
Neuromatch software package, by GE Healthcare (2 mentions)
Electrochemiluminescence immunoassay, by Roche (2 mentions)
Chemiluminescence immunoassay, by Siemens (2 mentions)
Xeleris, by GE Healthcare (1 mentions)
24 protocols using infinia hawkeye
1
Multimodal Imaging of I-131 CLR1404 Biodistribution
2
Measuring Amyloid Burden through SAP Imaging
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Anterior and posterior whole-body images were acquired following 123I-SAP administration using a General Electric Infinia Hawkeye or Discovery 670 Gamma Camera (GE) with extended low-energy general-purpose collimators. Liver and spleen amyloid burden was scored by visual assessment into 4 categories (no visceral organ uptake on SAP scintigraphy, small, moderate, and large amyloid loads). Analysis was carried out by operators blinded to all other investigations and patient outcomes.2 (link)
3
SPECT Brain Imaging Protocol for Cerebral Hemodynamics
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SPECT brain scans were carried out in a dark and quiet environment according to our previous study [6 (link)]. 925 MBq of ethylcysteinate dimer (99mTC-ECD, China institute of atomic energy, China) was injected into the antecubital vein. The images were taken by the SPECT scanner (Infinia Hawkeye; General Electric Company, USA) after one hour. The images were taken per 6° during rotation of 360° and at a rate of 35 s per frame. The data were acquired on a 128 × 128 matrix.
ROI selection and data analysis were also according to previous studies [6 (link), 16 (link)]. NeuroMatch Software package (GE Medical Systems; Segami Corporation, Columbia, MD, USA) was used for the ROI selection. Four slices of cerebral hemisphere were selected on orbitomeatal line (OML) + 55 mm, + 58 mm, + 61 mm, and + 64 mm.Six pairs of sphenoid mirrored ROIs over cortical gray matter were drawn at each slice of cerebral hemisphere. Four middle ROIs corresponding to the MCA territory were selected, and the mean value of four slices in each ROI was used for data analysis. However, mirrored ROIs were also drawn in one slice of cerebellar hemisphere (OML + 15 mm) for normalization of cerebral hemodynamic parameters.
ROI selection and data analysis were also according to previous studies [6 (link), 16 (link)]. NeuroMatch Software package (GE Medical Systems; Segami Corporation, Columbia, MD, USA) was used for the ROI selection. Four slices of cerebral hemisphere were selected on orbitomeatal line (OML) + 55 mm, + 58 mm, + 61 mm, and + 64 mm.Six pairs of sphenoid mirrored ROIs over cortical gray matter were drawn at each slice of cerebral hemisphere. Four middle ROIs corresponding to the MCA territory were selected, and the mean value of four slices in each ROI was used for data analysis. However, mirrored ROIs were also drawn in one slice of cerebellar hemisphere (OML + 15 mm) for normalization of cerebral hemodynamic parameters.
4
Cardiac Amyloidosis Imaging Protocol
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All patients were investigated with an Infinia Hawkeye hybrid single-photon-emission computed-tomography gamma camera (SPECT-CT; General Electric Medical Systems) with a low-energy, high-resolution collimator. An intravenous injection of ~750 MBq DPD was performed 3 h prior to the acquisition of a whole-body planar image, followed by a non-contrast, low-dose CT scan and a SPECT acquisition, which provided 60 projections, iteratively reconstructed into a 128 × 128 matrix (OSEM, 3 iterations, 10 subsets) with scatter and CT-based attenuation correction. Reconstruction of SPECT images was performed on the Xeleris workstation (GE Healthcare, Chicago, IL, USA). DPD scores were reported by two experienced clinicians using the Perugini grading system [21 (link)], with grade 0 being negative and grades 1–3 increasingly positive.
5
Resting SPECT/CT Imaging of Feet Before and After Revascularization
6
Thyroid Function Assessment Protocol
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Tg and TgAb levels were determined by electrochemiluminescence immunoassay (Roche Diagnostics GmbH, Mannheim, Germany) with a functional sensitivity of 0.100 ng/mL and 10 IU/mL, respectively. TSH was determined by chemiluminescence immunoassay (Siemens Healthcare Diagnostics Inc, New York, New York, USA), with a measuring range from 0.004 to 150μIU/mL. TgAb values>115 IU/mL were considered positive. Rx-WBS was obtained in the anterior and posterior projections using dual-head gamma cameras (Infinia Hawkeye; GE, Fairfield, Connecticut, USA) equipped with high-energy parallel-hole collimators, and a 20% energy window was centered at 364 keV, at a table speed of 20 cm/min for a total time of 15 min (256×1024 matrix).
7
Bone Scintigraphy with 99mTc-MDP
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Bone scintigraphy was performed using a dual-head gamma camera (Infinia Hawkeye, GE Healthcare, Milwaukee, WI, USA) equipped with a low-energy general-purpose collimator. Bone scan images were acquired 3–4 h after the intravenous injection of 740 MBq (20 mCi) of 99mTc-MDP at a scanning speed of 15 cm/min.
8
Planar γ-Imaging of 177Lu-3PRGD2 in U87MG Xenografts
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For the planar γ- imaging, the U87MG tumor-bearing nude mice were anesthetized with an intraperitoneal injection of sodium pentobarbital at a dose of 45.0 mg/kg. Each animal was administered with ~74 MBq of 177Lu-3PRGD2 in 0.2 mL of saline (n = 3 per group). Animals were placed on a two-head γ-camera (GE Infinia Hawkeye) equipped with a parallel-hole, low-energy, and high-resolution collimator. Images were acquired at 4 h and 24 h p.i., and stored digitally in a 128×128 matrix. The acquisition count limits were set at 500 k counts.
9
Tracking Dendritic Cell Migration
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DC migration studies were done at the fourth vaccination. Patients were randomized by side to have one inguinal vaccination site pre-treated with either 1 × 106 unpulsed DCs or Td toxoid (1 flocculation unit (Lf)). Saline was administered on the contralateral side. Vaccination site pretreatment was done 6 to 24 hours before DC vaccination. DCs were labeled with 10 μCi / 1 × 107 DC with 111In (GE Healthcare, Arlington Heights, IL) and divided equally in the two sites. Gamma camera images (GE Infinia Hawkeye) were taken immediately after injection and at 24 and 48 hours after injection to compare 111In-labeled DC migration from the inguinal injection sites to the inguinal lymph nodes.
10
SPECT Imaging for Longitudinal Brain Perfusion
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A SPECT study was performed twice in each patient using a dual-head, variable-angle SPECT gamma camera (Infinia Hawkeye; GE Healthcare, Haifa, Israel). The baseline study was performed at 15 minutes after intravenous injection of Tc-99m-hexamethylpropylenaminoxime, while the second SPECT study was performed at eight weeks after the same.14) (link) SPECT data were analyzed using Statistical Parametric Mapping 12 (SPM; Wellcome Department of Cognitive Neurology, Institute of Neurology, London, UK). All images were spatially normalized to the SPM SPECT template (Montreal Neurological Institute, McGill University, Montreal, Canada) using a 12-parameter affine transformation, followed by nonlinear transformations and trilinear interpolation. Images were resliced with a voxel size of 2 × 2 × 2 mm and smoothed with a 12-mm, full-width half-maximum Gaussian kernel. Normalized regional CBF maps were created using proportional scaling. Global counts were scaled to 50 ml/100 g/min.
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