Qx314 chloride qx314

Manufactured by Merck Group

QX314 chloride (QX314) is a chemical compound that is commonly used in laboratory settings. It is a quaternary ammonium salt with the chemical formula C14H26ClNO. QX314 has a specific function as a sodium channel blocker, which can be utilized in various experimental applications. However, a detailed description of its intended use would require further information that is not available within the scope of this request.

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Lab products found in correlation

Nicotine hydrogen tartrate salt, by Glentham Life Sciences (3 mentions) D 2 amino 5 phosphonopentanoic acid d ap5, by Bio-Techne (3 mentions) 4 aminopyridine 4 ap, by Merck Group (2 mentions) 6 cyano 7 nitroquinoxaline 2 3 dione cnqx, by Bio-Techne (2 mentions) Tetrodotoxin ttx, by Abcam (1 mentions) Aav5 ef1a dio hchr2 h134r eyfp wpre hgh, by Addgene (1 mentions) Methyllycaconitine mla, by Bio-Techne (1 mentions) Tetrodotoxin citrate ttx, by Abcam (1 mentions)

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QX314 chloride (2 citations)

3 protocols using qx314 chloride qx314

Pharmacological Tools for Neurophysiology

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Dihydro-β-erythroidine hydrobromide (DHβE), methyllycaconitine (MLA), picrotoxin (PTX), atropine sulfate (atropine), and 4-aminopyridine (4-AP) were obtained from Sigma-Aldrich. 6-Cyano-7-nitroquinoxaline-2,3-dione (CNQX), and d(−)-2-amino-5-phosphonopentanoic acid (d-AP5) were obtained from Tocris Bioscience. QX314 chloride (QX314) was from EMD-Millipore. Tetrodotoxin (TTX) was obtained from Abcam. Nicotine hydrogen tartrate salt was obtained from Glentham Life Sciences. AAV5.EF1a.DIO.hChR2(H134R)-eYFP.WPRE.hGH was obtained from Addgene.

Yan Y., Beckley N.A., Kim V.J, & Drenan R.M. (2019). Differential Nicotinic Modulation of Glutamatergic and GABAergic VTA Microcircuits. eNeuro, 6(6), ENEURO.0298-19.2019.

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Pharmacological Modulation of Neuronal Receptors

Cited 1 time

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Picrotoxin (PTX), atropine sulfate (atropine), acetylcholine chloride, and N-(5-Chloro-2-hydroxyphenyl)-N’-[2-chloro-5-(trifluoromethyl)phenyl]urea (NS1738) were obtained from Sigma. 6-Cyano-7-nitroquinoxaline-2,3-dione (CNQX), N-(5-chloro2,4-dimethoxyphenyl)-N′-(5-methyl-3-isoxazolyl)-urea (PNU-120596), methyllycaconitine (MLA), and D-(−)-2-Amino-5-phosphonopentanoic acid (D-AP5) were obtained from Tocris. QX314 chloride (QX314) was from EMD-Millipore. Nicotine hydrogen tartrate salt was obtained from Glentham Life Sciences. PA-Nic was synthesized as previously described (Banala et al., 2018 (link)) and was a generous gift from Dr. Luke Lavis (Janelia Research Campus, Howard Hughes Medical Institute).

Jin X.T, & Drenan R.M. (2022). Functional α7 nicotinic acetylcholine receptors in GABAergic neurons of the interpeduncular nucleus. Neuropharmacology, 208, 108987.

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Neurotransmitter Receptor Modulation Assay

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Picrotoxin (PTX), atropine sulfate (atropine), acetylcholine chloride, and 4-aminopyridine (4AP) were obtained from Sigma. 6-Cyano-7-nitroquinoxaline-2,3-dione (CNQX) and D-(-)−2-amino-5-phosphonopentanoic acid (D-AP5) were obtained from Tocris. QX314 chloride (QX314) was from EMD-Millipore. Tetrodotoxin citrate (TTX) was obtained from Abcam. Nicotine hydrogen tartrate salt was obtained from Glentham Life Sciences. Injectable heparin sodium was from Patterson Veterinary Supply.

Jin X.T., Tucker B.R, & Drenan R.M. (2020). Nicotine Self-Administration Induces Plastic Changes to Nicotinic Receptors in Medial Habenula. eNeuro, 7(4), ENEURO.0197-20.2020.

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