C57l j

Manufactured by Jackson ImmunoResearch

C57L/J is a mouse strain that can be used for research purposes. It is an inbred laboratory mouse strain.

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4 protocols using c57l j

Histologic Evaluation of Mouse Hearts

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Ten female and 10 male mice were obtained from The Jackson Laboratory (Bar Harbor, ME) as retired breeders (i.e., 5–10 months of age depending on the rotation time for the colony)(Flurky et al. 2009 ) from the following 16 inbred strains: A/J, BALB/cByJ, BALB/cJ, C3H/HeJ, C57BL/6J, C57BL/10J, C57BR/cdJ, C57L/J, DBA/2J, FVB/NJ, KK/HlJ, LP/J, PWD/PhJ, SWR/J, MRL/MpJ-Fas^lpr/J, and SJL/J. Mice were euthanized by CO₂ asphyxiation, weighed, and the hearts were removed and processed for histologic evaluation.
All protocols were reviewed and approved by The Jackson Laboratory Animal Care and Use Committee. Mouse handling and care were followed according to the Public Health Service animal welfare policies using IACUC approved methods.

Li Q., Berndt A., Sundberg B.A., Silva K.A., Kennedy V.E., Cario C.L., Richardson M.A., Chase T.H., Schofield P.N., Uitto J, & Sundberg J.P. (2016). Mouse genome-wide association study identifies polymorphisms on chromosomes 4, 11 and 15 for age-related cardiac fibrosis. Mammalian genome : official journal of the International Mammalian Genome Society, 27(5-6), 179-190.

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Genetic Diversity of Mouse Strains

Cited 1 time

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129S1/SvImJ, A/J, AKR/J, BALB/cByJ, BTBRT⁺tf/J, BUB/BnJ, C3H/HeJ, C57BL/10J, C57BL/6J, C57BLKS/J, C57BR/cdJ, C57L/J, CAST/EiJ, CBA/J, DBA/2J, FVB/NJ, KK/HlJ, LP/J, MRL/MpJ, NOD.B10Sn-H2^b/J (a congenic strain with the NOD genetic background but with a histocompatibility locus from a diabetes-resistant strain), NON/ShiLtJ, NZO/HlLtJ, NZW/LacJ, P/J, PL/J, PWD/PhJ, RIIIS/J, SJL/J, SM/J, SWR/J, and WSB/J were obtained from The Jackson Laboratory (Bar Harbor, ME). Three of the strains were not evaluated at all time points because of lymphoma development (AKR/J), lack of sufficient mice for analysis (CAST/EiJ), or self-mutilations resulting in euthanasia for humane purposes (SJL/J). (9 , 10 (link)) Taken together the strains selected were genetically diverse, which was estimated by SNP genotyping of over 100 strains into 7 distinct genetic groups, so that there were 3–7 strains representing each of the groups.(11 (link))

Linn S.C., Mustonen A.M., Silva K.A., Kennedy V.E., Sundberg B.A., Bechtold L.S., Alghamdi S., Hoehndorf R., Schofield P.N, & Sundberg J.P. (2018). Nail Abnormalities Identified in an Aging Study of 30 Inbred Mouse Strains. Experimental dermatology, 28(4), 383-390.

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Generating NZM2328.C57L/Jc1 Congenic Mice

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NZM2328 and C57L/J breeding pairs were obtained from the Jackson Laboratory (Bar Harbor, Maine). The NZM2328.C57L/Jc1 (NZM. Lc1) congenic line was generated using a microsatellite marker assisted speed congenic method described by Ge et al. [7 (link)]. Intrachromsomal recombinant strains of NZM.Lc1 were generated as described [3 (link)]. Mice were kept at the University of Virginia Center of Comparative Medicine under pathogen-free conditions. Female mice were used to determine their resistance to the development of cGN with severe proteinuria and early mortality. Male mice were used in the EAO model. The animal experimental protocols were approved by the Institutional Animal Care Committee. All mice were used in a manner in full compliance with federal regulations (PHS Policy and Animal Welfare Act).

Zhao Z., Qiao H., Ge Y., Kannapel C.C., Sung S.S., Gaskin F., Tung K.S, & Fu S.M. (2021). Autoimmune experimental orchitis and chronic glomerulonephritis with end stage renal disease are controlled by Cgnz1 for susceptibility to end organ damage. Clinical immunology (Orlando, Fla.), 224, 108675.

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Murine Radiation Exposure Study

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Experiments were conducted at Duke University (Durham, NC) and the University of Maryland School of Medicine (UMSOM, Baltimore, MD). All experiments were performed in compliance with the Animal Use Protocols approved by the Institutional Animal Care and Use Committee at each institution. To establish the natural history of disease progression across murine strains, age- and sex-matched C57L/J, CBA/J and C57BL/6J mice were purchased from Jackson Labs, Bar Harbor, ME, and allowed to acclimate for 2 weeks prior to radiation exposure. Age- and sex-matched sham-irradiated controls were included for comparison of normal lung tissue among mice. Animals were identified by ear tags with a unique ID number and cage card throughout the study. Animal holding rooms were maintained at 21±3°C with 30-70% relative humidity. A 12-h light/dark cycle was maintained with lights turned on at ∼07:00 h and off at ∼19:00 h. Animals were provided hyperchlorinated (10 ppm) water and fed 2018SX Teklad Global 18% Protein Extruded rodent diet ad libitum throughout the study.

Jackson I.L., Baye F., Goswami C.P., Katz B.P., Zodda A., Pavlovic R., Gurung G., Winans D, & Vujaskovic Z. (2017). Gene expression profiles among murine strains segregate with distinct differences in the progression of radiation-induced lung disease. Disease Models & Mechanisms, 10(4), 425-437.

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