Poly ethylene glycol methyl ether mpeg oh

Manufactured by Merck Group

Poly(ethylene glycol) methyl ether (mPEG-OH) is a water-soluble, non-toxic, and biocompatible polymer. It is commonly used as a building block in the synthesis of various chemical compounds and materials. The core function of mPEG-OH is to provide a stable, inert, and hydrophilic moiety that can be attached to other molecules or surfaces to modify their properties.

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Lab products found in correlation

4 dimethylaminopyridine dmap, by Merck Group (2 mentions) Dii 1 10 dioctadecyl 3 3 3030 tetramethylindocarbocyanine perchlorate d 307, by Thermo Fisher Scientific (1 mentions) Docetaxel dtx, by LC Laboratories (1 mentions) Cabazitaxel, by LC Laboratories (1 mentions)

Spelling variants of this product

Ethylene glycol (580 citations) Poly(ethylene glycol) methyl ether (19 citations) MPEG-OH (5 citations) Poly(ethylene glycol) methyl ether (mPEG, (4 citations)

2 protocols using poly ethylene glycol methyl ether mpeg oh

Synthesis and Characterization of DTX-Loaded Nanocarriers

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Docetaxel (DTX) was obtained from LC Laboratories (Woburn, MA). Carboxymethylcellulose (CMC) sodium salt (CEKOL 30000-P) was purchased from CPKelco (Atlanta, GA). Poly(ethylene glycol) methyl ether (mPEG − OH, MW = 2000), N-hydroxysuccinimide (NHS), 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide HCl (EDC.HCl), and 4-dimethylaminopyridine (DMAP) were purchased from Sigma Aldrich (Oakville, ON). Hydrophobic fluorescent dye DiI (1,10-dioctadecyl-3,3,3030-tetramethylindocarbocyanine perchlorate, D-307) was purchased from Invitrogen (Burlington, ON).Taxotere (native DTX) were purchased from the University Health Network pharmacy (Toronto, ON). For all the in vitro studies, free DTX was first dissolved in DMSO and then diluted with DMEM medium.

Roy A., Murakami M., Ernsting M.J., Hoang B., Undzys E, & Li S.D. (2014). Carboxymethylcellulose-based and docetaxel-loaded nanoparticles circumvent P-glycoprotein mediated multidrug resistance. Molecular pharmaceutics, 11(8), 2592-2599.

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Synthesis and Characterization of Cytotoxic Nanoparticles

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Podophyllotoxin (PPT) was obtained from Carbosynth (Berkshire, UK). Docetaxel (DTX), Paclitaxel (PTX) and Cabazitaxel (CBZ) were obtained from LC Laboratories (Woburn, MA). Cholchicin (Cho) and Vinblastin (Vin) were purchased from Sigma Aldrich (Oakville, ON). Carboxymethylcellulose (CMC) sodium salt (CEKOL 30000-P) was purchased from CPKelco (Atlanta, GA). Poly(ethylene glycol) methyl ether (mPEG−OH, MW = 2000), 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide HCl (EDC.HCl), and 4-dimethylaminopyridine (DMAP) were purchased from Sigma Aldrich (Oakville, ON). Hydrophobic fluorescent dye DiI (1,1`-dioctadecyl-3,3,3`,3`-tetramethylindocarbocyanine perchlorate, D-307) was purchased from Invitrogen (Burlington, ON). For all the in vitro studies, free drugs were first dissolved in DMSO and then diluted with DMEM medium.

Roy A., Ernsting M.J., Undzys E, & Li S.D. (2015). A highly tumor-targeted nanoparticle of podophyllotoxin penetrated tumor core and regressed multidrug resistant tumors. Biomaterials, 52, 335-346.

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