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Dasatinib

Manufactured by ChemScene
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Sourced in United States

Dasatinib is a broad-spectrum kinase inhibitor. It functions by inhibiting the activity of multiple tyrosine kinases, including Bcr-Abl, Src family kinases, c-Kit, and PDGFR. Dasatinib is commonly used in research applications to investigate the role of these kinases in various cellular processes and disease models.

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Lab products found in correlation

Ponatinib, by ChemScene (1 mentions) Potassium dihydrogen phosphate, by Nacalai Tesque (1 mentions) Isopropanol, by Nacalai Tesque (1 mentions) Phosphoric acid, by Nacalai Tesque (1 mentions) Bosutinib, by Cayman Chemical (1 mentions) Methanol hplc grade, by Nacalai Tesque (1 mentions) Pooled human serum, by Cosmo Bio (1 mentions) Hplc grade acetonitrile, by Merck Group (1 mentions) Nilotinib, by ChemScene (1 mentions) Verteporfin, by Fujifilm (1 mentions) Anti mouse cd45 antibody, by BD (1 mentions)

2 protocols using dasatinib

1

Quantification of Tyrosine Kinase Inhibitors

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Dasatinib (98.44%), nilotinib (99.77%), and ponatinib (98.96%) were obtained from ChemScene; bosutinib (≥98%) was obtained from Cayman Chemical; HPLC‐grade acetonitrile was obtained from Merck KGaA; and potassium dihydrogen phosphate, phosphoric acid, HPLC‐grade methanol, and isopropanol were obtained from Nacalai Tesque. Pooled human serum was obtained from Cosmo Bio.
Yokoyama Y., Nozawa E., Morita M., Ishikawa E., Mori T., Sakurai M., Kikuchi T., Matsuki E., Yamazaki R., Kataoka K., Jibiki A., Kawazoe H., Suzuki S, & Nakamura T. (2022). Simultaneous quantification of dasatinib, nilotinib, bosutinib, and ponatinib using high‐performance liquid chromatography–Photodiode array detection. Journal of Clinical Laboratory Analysis, 36(8), e24598.
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2

Antibody-based Cellular Assay Reagents

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Verteporfin and reduced-form GSH were purchased from Wako Pure Chemical Industries (Osaka, Japan). Dasatinib and menadione was obtained from Chemscene (Princeton, NJ, USA) and Sigma Aldrich (St. Louis, MO, USA), respectively. An anti-human CD19 antibody and anti-mouse CD45 antibody were purchased from BD Biosciences (San Jose, CA, USA).
Morishita T., Hayakawa F., Sugimoto K., Iwase M., Yamamoto H., Hirano D., Kojima Y., Imoto N., Naoe T, & Kiyoi H. (2016). The photosensitizer verteporfin has light-independent anti-leukemic activity for Ph-positive acute lymphoblastic leukemia and synergistically works with dasatinib. Oncotarget, 7(35), 56241-56252.
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