Mr750

Manufactured by GE Healthcare

Sourced in United States, Germany

The MR750 is a magnetic resonance imaging (MRI) system developed by GE Healthcare. It is designed to produce high-quality images of the human body for diagnostic and medical purposes. The MR750 utilizes powerful magnetic fields and radio waves to non-invasively capture detailed images of internal structures, enabling healthcare professionals to assess and diagnose various medical conditions.

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MR750 3T scanner (90 citations) Discovery MR750 3T scanner (55 citations) Signa MR750 (17 citations) Discovery MR750 3.0 T system (15 citations) Discovery 3T GE-MR750 (11 citations) Discovery MR750 3.0T MRI scanner (9 citations) General Electric Discovery MR750 (5 citations) Discovery MR750 HDx (5 citations) 3Tesla MR750 scanner (4 citations) GE-MR750 3.0 T scanner (4 citations)

286 protocols using mr750

3D MRI and fMRI Acquisition Protocol

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Three-dimensional MR imaging was acquired using a GE 3 T scanner (MR750, GE Medical Systems, Milwaukee, WI) with a 32-channel radio frequency coil at the Center for Cognition and Brain Disorders (CCBD), Hangzhou Normal University (HZNU). Foam filling was used to reduce head movement for all subjects. During scanning, the subjects were asked to relax and remain still. Using a magnetization-prepared rapid acquisition gradient-echo sequence, three-dimensional T1-weighted anatomical images were obtained in the sagittal orientation (TR = 9 ms, TE = 3.664 ms, FOV = 240 × 240 mm², matrix = 300 × 300, flip angle = 13°, thickness = 0.8 mm, acquisition time = 13 min 37 s). fMR images were acquired using a gradient-recalled echo-planar imaging sequence (TR = 2000 ms, TE = 22 ms, FOV = 240 × 240 mm², matrix = 96 × 96, flip angle = 77°, slice thickness = 2.5 mm, no interslice gap, and 240 volumes).

Li H., Song S., Wang D., Tan Z., Lian Z., Wang Y., Zhou X, & Pan C. (2021). Individualized diagnosis of major depressive disorder via multivariate pattern analysis of thalamic sMRI features. BMC Psychiatry, 21, 415.

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Resting-state fMRI Acquisition Protocol

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All imaging data were obtained with a 3.0 T scanner (MR750, GE Healthcare, Milwaukee, WI, United States) equipped with a 32-channel head coil. The participants’ heads were fastened by cushions between both sides of their head and coil to minimize the head movements. During the scanning, the participants were required to relax their minds and not think about anything, keeping awake with their eyes closed. Each participant received one functional scan. The rs-fMRI data were measured with an echo-planar imaging sequence (TR/TE = 2,000/30 ms, flip angle = 90°, FOV = 220 mm × 220 mm, 43 axial slices, acquisition matrix = 64 × 64, voxel size = 3.4 mm × 3.4 mm × 3.2 mm, interslice space = 0 mm). Structural imaging data were acquired with a 3D T1-weighted fast spoiled gradient-recalled echo sequence (TR/TE = 8.16/3.18 ms, inversion time = 450 ms, flip angle = 8°, FOV = 256 mm × 256 mm, acquisition matrix = 256 × 256, spatial resolution = 1 mm × 1 mm × 1 mm, interslice space = 0 mm).

Shen Y., Wang W., Wang Y., Yang L., Yuan C., Yang Y., Wu F., Wang J., Deng Y., Wang X, & Liu H. (2022). Not Only in Sensorimotor Network: Local and Distant Cerebral Inherent Activity of Chronic Ankle Instability—A Resting-State fMRI Study. Frontiers in Neuroscience, 16, 835538.

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Multimodal Brain Imaging Protocol

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Brain imaging data will be collected using the 3T magnetic resonance imaging scanner (GE Healthcare MR750) and include longitudinal relaxation time (T1) and transverse relaxation time relaxometry using steady-state sequences (multicomponent Driven Equilibrium Single Pulse Observation of T1 and transverse relaxation time) [86 (link),87 (link)]. Structural imaging of anatomical detail for morphometric analyses will be performed using a custom magnetization-prepared rapid acquisition gradient echo sequence, which removes the intensity variations from inhomogeneities in the coil sensitivities. Functional blood-oxygen-level-dependent images may be recorded using a reverse spiral sequence (repetition time=1000 ms, time to echo=32 ms, flip angle=60°, 56 sagittal slices, field-of-view=208 mm, slice thickness=2.5 mm, and voxel size=2.5×2.5×2.5 mm). Each sequence will take 1 to 10 minutes, and the total scan time will be 60 minutes.

Cascio C.N., Selkie E, & Moreno M.A. (2023). Effect of Technology and Digital Media Use on Adolescent Health and Development: Protocol for a Multimethod Longitudinal Study. JMIR Research Protocols, 12, e50984.

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Liver Fat Quantification using MRI

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MRI was performed within 1‒2 days before surgery. All patients underwent non-contrast scans using a 3.0-Tesla MRI scanner (MR750, GE Healthcare, Waukesha, WI, USA) with an eight-channel phased-array body coil centred over the liver. The patients were instructed to fast for 6 h before undergoing scanning with feet first in the supine position. A six-echo spoiled gradient-recalled-echo magnitude-based fat quantification technique was used. The parameters were as follows: repetition time, 7.3 ms; echo time, six different echoes ranging from 1.0 to 5.0 ms to permit correction for R2* signal decay and chemical-shift-based separation of fat and water signals; matrix, 160 × 160; field-of-vision, 40 cm; slice-section thickness, 8 mm; number of excitations, 0.5; flip angle, low (4°) to minimise T1 bias [34 (link)]; bandwidth, 111.11; and acquisition time, 21 s. Respiratory bellows were applied to monitor breathing, and the patients were instructed to hold their breath during image acquisition. The sequences were planned such that the whole liver was covered.

Cao D., Li M., Liu Y., Jin H., Yang D., Xu H., Lv H., Liu J., Zhang P., Zhang Z, & Yang Z. (2022). Comparison of reader agreement, correlation with liver biopsy, and time-burden sampling strategies for liver proton density fat fraction measured using magnetic resonance imaging in patients with obesity: a secondary cross-sectional study. BMC Medical Imaging, 22, 92.

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Four-Dimensional Flow MRI and Structural Imaging

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Subjects were scanned using a clinical 3T MRI system (MR750; GE Healthcare, Waukesha, WI, USA) with an 8-channel head coil (Excite HD Brain Coil; GE Healthcare). Four-dimensional flow MRI data were acquired with PC VIPR [13] (link). Scan parameters were as follows: venc = 80 cm/s, imaging volume = 22 cm³, acquired isotropic spatial resolution = 0.7 mm³, repetition time (TR)/echo time (TE) = 7.4/2.7 ms, flip angle α = 10°, bandwidth = 83.3 KHz, 14,000 projection angles, scan time ∼ 7 minutes, and retrospective cardiac gating reconstructed into 20 cardiac phases with temporal interpolation [17] (link). A T1-weighted volume was acquired in the axial plane with a three-dimensional (3D) fast spoiled gradient echo-sequence using the following parameters: inversion time (TI) = 450 ms; TR = 8.1 ms; TE = 3.2 ms; flip angle = 12°; acquisition matrix = 256 × 256; field of view (FOV) = 256 mm; and slice thickness = 1.0 mm. A 3D T2-weighted fluid attenuated inversion recovery sequence was acquired in the sagittal plane using the following parameters: TI = 1868 ms, TR = 6000 ms; TE = 123 ms; flip angle = 90°; acquisition matrix = 256 × 256; FOV = 256 mm; slice thickness = 2.0 mm, and no gap yielding a voxel resolution of 1 mm × 1 mm × 2 mm. MRI images were read by one of the authors for anomalies that required patient notification.

Berman S.E., Rivera-Rivera L.A., Clark L.R., Racine A.M., Keevil J.G., Bratzke L.C., Carlsson C.M., Bendlin B.B., Rowley H.A., Blennow K., Zetterberg H., Asthana S., Turski P., Johnson S.C, & Wieben O. (2015). Intracranial arterial four-dimensional flow is associated with metrics of brain health and Alzheimer's disease. Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring, 1(4), 420-428.

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Multimodal MRI Phantom Imaging Protocol

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All imaging studies were performed on a whole-body 3 T MRI scanner (MR750, GE Healthcare, Waukesha, WI, USA), with multi-nuclear excite and 32-channel receive capability.
For the phantom study, proton imaging was performed using the body coil for excitation and a 4-channel surface coil for reception. Carbon imaging was performed using a clamshell volume transmitter^{25 (link)} and a 16-channel bilateral receive array (Rapid Biomedical, Rimpar, Germany). The anterior and posterior arrays, each housing 8 coil elements with a 4 × 2 layout, were placed above and below the phantom for whole volume coverage (Figure 2f).
An abdominal-sized phantom containing natural abundance ethylene glycol and comprised of multiple signal voids was imaged by a ¹H T₂-weighted sequence and a ¹³C spectroscopy sequence. The ¹³C data were acquired from a 10 cm axial slice with an in-plane field-of-view (FOV) of 36 × 32 cm² (RL × AP) and in-plane resolution of 2.0 × 2.0 cm². An echo-planar spectroscopic imaging (EPSI) readout gradient was applied to encode one spatial (RL) dimension and the spectral dimension, with a readout bandwidth of 545 Hz and a spectral resolution of 10 Hz. 16 phase encodes were applied in the AP direction, and each was excited by a constant 90° sinc pulse with TR/TE = 312/3.5 ms. A total of 5 signal averages were acquired, resulting in a 25-second scan time.

Zhu Z., Zhu X., Ohliger M.A., Tang S., Cao P., Carvajal L., Autry A.W., Li Y., Kurhanewicz J., Chang S., Aggarwal R., Munster P., Xu D., Larson P.E., Vigneron D.B, & Gordon J.W. (2019). Coil Combination Methods for Multi-Channel Hyperpolarized 13C Imaging Data from Human Studies. Journal of magnetic resonance (San Diego, Calif. : 1997), 301, 73-79.

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High-Resolution 3D T1-Weighted Imaging

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High‐resolution three‐dimensional (3D) T1‐weighted images were acquired on a 3.0T GE MR750 at University College London (London, United Kingdom), and a 3.0T Siemens Skyra at Case Western Reserve University Hospitals (Cleveland, Ohio, United States). Image acquisition parameters (UCL/UH) were as follows: FOV (mm) = 224 × 256 × 256/230 × 173 × 230; acquisition matrix = 224 × 256 × 256/256 × 192 × 256; voxel size (mm) = 1.0 × 1.0 × 1.0/0.7 × 0.9 × 0.7; TR (repetition time, ms) = 7.4/7.3; TE (echo time, ms) = 3.1/2.38; TI (inversion time, ms) = 400/900; flip angle (degrees) = 11/9.

Allen L.A., Harper R.M., Vos S.B., Scott C.A., Lacuey N., Vilella L., Winston J.S., Whatley B.P., Kumar R., Ogren J., Hampson J.S., Rani S., Winston G.P., Lemieux L., Lhatoo S.D, & Diehl B. (2020). Peri‐ictal hypoxia is related to extent of regional brain volume loss accompanying generalized tonic‐clonic seizures. Epilepsia, 61(8), 1570-1580.

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Longitudinal fMRI Evaluation of Cortical Plasticity

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The fMRI scan was carried out with a 3.0T scanner (MR750, GE Healthcare, USA). The participants underwent a protocol including one task-dependent block-design BOLD sequence and a FSPGR 3D-T1 sequence. The first fMRI scan was performed before the surgery, and the second one was performed 6 months after surgery, which allowed enough time for cortical plasticity and avoided the interference of surgical incision-related pain. Considering subjects' individual arrangement, a 2-week variation was allowed.
Foam padding was utilized to reduce head motion. For structural 3D-T1 imaging, we used the FSPGR sequence as follows: matrix size = 256 × 256, FOV = 256 × 256 mm, TR/TE = 8100/3.1 ms, FA = 8°, slice thickness = 1 mm, gap = 0 (isotropic voxel size = 1 × 1 × 1 mm), and TI (prepare time) = 450 milliseconds. For BOLD sequences, the parameters were as follows: sequence = GRE-EPI, interleaved scanning order, slice number = 43, matrix size = 64 × 64, FOV = 220∗220 mm, TR = 3000 ms, FA = 90°, slice thickness = 3.2 mm, gap = 0 (voxel size 3.4 × 3.4 × 3.2 mm³), and number of acquisitions = 120.

Ma H., Lu Y., Hua X., Shen Y., Zheng M, & Xu W. (2017). A Longitudinal fMRI Research on Neural Plasticity and Sensory Outcome of Carpal Tunnel Syndrome. Neural Plasticity, 2017, 5101925.

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Multimodal Brain Imaging Protocol

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This study was approved by a local ethical review committee. Healthy volunteers ≥ 18 years old were recruited for imaging and were required to provide informed written consent. Imaging was conducted using a clinical 3 T MRI system (MR750, GE Healthcare, Waukesha, WI, USA). A volumetric inversion-recovery prepared T₁-weighted gradient-echo sequence (resolution 0.94 × 0.94 × 1.00 mm, FOV 240 mm, TE 3.2 ms, TR 8.2 ms, IR 450 ms, FA 12 deg.) was acquired for co-registration, tissue segmentation and region-of-interest (ROI) delineation. DWI images were acquired as follows: 30 directions, four b-values (0, 100, 1000 and 2000s/mm²), 16 axial slices centred on the splenium of the corpus callosum, dual-spin echo echo-planar imaging, acquired resolution 1.12 × 1.12 × 2.00 mm, reconstructed resolution 0.86 × 0.86 × 2.00 mm, FOV 220 mm, TE 102 ms, TR 2000 ms.

Maiter A., Riemer F., Allinson K., Zaccagna F., Crispin-Ortuzar M., Gehrung M., McLean M.A., Priest A.N., Grist J., Matys T., Graves M.J, & Gallagher F.A. (2021). Investigating the relationship between diffusion kurtosis tensor imaging (DKTI) and histology within the normal human brain. Scientific Reports, 11, 8857.

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Myocardial Infarction and Hemorrhage Assessment

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Hemorrhage was artificially induced in a pig model by direct intracoronary injection of collagenase (col) [5]. Animals (N = 14) were divided into three groups and subjected to an LAD occlusion followed by reperfusion: Group 1 (N = 4) 45 min+saline (sal); Group 2 (N = 5): 8 min+col; and Group 3 (N = 5): 45 min+col. Imaging was serially performed on a 3T MRI scanner (MR 750, GE Healthcare) at baseline (healthy) and up to week 4 post-intervention. Pre- and post-contrast T1 values were quantified using a MOLLI sequence. Partition coefficient (λ) was estimated from the relation:(1/T1_myo,post-1/T1_myo,pre)/(1/T1_blood,post-1/T1_blood,pre). T2 mapping was performed using a T2-prepared spiral sequence. Hemorrhage was assessed from T2* maps obtained using a multi-echo gradient-echo acquisition. Infarcted and remote myocardial segments were evaluated based on LGE images.

Ghugre N.R., Ramanan V., Assimopoulos S., Qi X., Barry J., Strauss B.H, & Wright G.A. (2016). T1 and T2 mapping reveal contribution of hemorrhage in myocardial remodeling following acute myocardial infarction. Journal of Cardiovascular Magnetic Resonance, 18(Suppl 1), Q5.

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