Glpg1837

Manufactured by Selleck Chemicals

Sourced in United States

GLPG1837 is a laboratory reagent used in chemical research and analysis. It is a small molecule compound that can be utilized as a research tool in various experimental settings. The core function of GLPG1837 is to serve as a chemical probe or standard for analytical procedures, without further interpretation of its intended use.

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Lab products found in correlation

Vx 809, by Selleck Chemicals (2 mentions) Cftrinh 172, by Selleck Chemicals (2 mentions) Vx 770, by Selleck Chemicals (2 mentions) Pti 428, by MedChemExpress (1 mentions) Vx 445, by MedChemExpress (1 mentions) Drug like synthetic compounds, by ChemDiv (1 mentions) Ivacaftor, by Selleck Chemicals (1 mentions)

3 protocols using glpg1837

Screening for CFTR Modulators

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VX-809, VX-770, GLPG1837 and CFTR_inh-172 were purchased from Selleck Chemicals (Boston, MA). VX-445 and PTI-428 were purchased from MedChemExpress (Monmouth Junction, NJ). Potentiators P2, P3 and P5 are contained in an in-house repository (19 (link)). For screening, a collection of ~50,000 compounds containing diverse drug-like synthetic small molecules (ChemDiv Inc., San Diego, CA) and an in-house repository of mutant CFTR modulators was tested. Other chemicals were purchased from MilliporeSigma (Burlington, MA).

Phuan P.W., Haggie P.M., Tan J.A., Rivera A.A., Finkbeiner W.E., Nielson D.W., Thomas M.M., Janahi I.A, & Verkman A.S. (2020). CFTR modulator therapy for cystic fibrosis caused by the rare c.3700A>G mutation. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 20(3), 452-459.

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High-Throughput Screening of CFTR Modulators

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VX-809, VX-770, GLPG1837 and CFTR_inh-172 were purchased from Selleck Chemicals (Boston, MA). Potentiators P2 (PG-01^{43 (link)}), P3 (SF-03^{43 (link)}) and P5 (∆F508_act-02^{44 (link)}) were obtained from an in-house repository of CFTR modulators. For screening, 120,000 diverse drug-like synthetic compounds (ChemDiv Inc., San Diego, CA) were tested. Other chemicals were purchased from Sigma unless otherwise stated.

Phuan P.W., Tan J.A., Rivera A.A., Zlock L., Nielson D.W., Finkbeiner W.E., Haggie P.M, & Verkman A.S. (2019). Nanomolar-potency ‘co-potentiator’ therapy for cystic fibrosis caused by a defined subset of minimal function CFTR mutants. Scientific Reports, 9, 17640.

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Evaluation of CFTR Modulators

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Ivacaftor and GLPG1837 were from Selleckchem (S1144 and S8698, respectively, Munich, DE, USA). SBC040 and SBC219 were synthesized by J.L. Decout (University Grenoble Alpes, France). All compounds were solubilized in DMSO as 1000 X concentrated stock solutions to treat cells with 0.5 or 10 µM final concentration, using DMSO as a control vehicle at the same dilution (0.1% DMSO for all conditions). After two hours of treatment with these drugs, cells were used for cytotoxicity or TC transport assays (see below).

Mareux E., Lapalus M., Ben Saad A., Zelli R., Lakli M., Riahi Y., Almes M., Banet M., Callebaut I., Decout J.L., Falguières T., Jacquemin E, & Gonzales E. (2022). In Vitro Rescue of the Bile Acid Transport Function of ABCB11 Variants by CFTR Potentiators. International Journal of Molecular Sciences, 23(18), 10758.

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