N n diisopropylethylamine dipea

Manufactured by Iris Biotech

Sourced in Germany

N,N-diisopropylethylamine (DIPEA) is a commonly used organic base in chemical synthesis and laboratory applications. It functions as a mild base and nucleophilic catalyst, often employed in reactions involving acid-sensitive substrates.

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Lab products found in correlation

Normal saline, by Merck Group (1 mentions) Tentagel s ram, by Rapp Polymere (1 mentions) Rocuronium bromide, by Fresenius (1 mentions) Piperidine, by Biosolve (1 mentions) Salicylaldehyde, by Merck Group (1 mentions) Fmoc rink amide mbha resin, by Iris Biotech (1 mentions) O 7 azabenzotriazol 1 yl n n n n tetramethyluronium hexafluorophosphate hatu, by Merck Group (1 mentions) N n dimethylformamide (dmf), by Iris Biotech (1 mentions) Disodium hydrogen phosphate, by Merck Group (1 mentions)

2 protocols using n n diisopropylethylamine dipea

Synthesis of Polystyrene-PEG Block Copolymer Resin

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A polystyrene-poly(ethylene glycol) 2000 block-copolymer resin, modified with Knorr linker Tentagel S RAM was from Rapp Polymere GmbH (Tübingen, Germany). Fmoc-protected amino acids, 4-methyl piperidine were from Mosinter (Ningbo, China). 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate (HATU), 1-Hydroxy-7-azabenzotriazole (HOAt) and DL-Dithiothreitol (DTT) were from DEMO Medical (Shanghai, China). N,N-diisopropylethylamine (DIPEA) was from Iris Biotech GmbH (Marktredwitz, Germany), trifluoroacetic acid from Solvay S.A. (Bruxelles, Belgium), normal saline (sterile 0.9% NaCl solution), complete Freund’s adjuvant and trinitrobenzenesulfonic acid (TNBS) from Sigma-Aldrich Chemie Gmbh (Munich, Germany), bovine serum albumin (BSA) from Amresko, Rocuronium Bromide from Fresenius Kabi (Bad Homburg, Germany). All other reagents and solvents of the highest purity available were purchased from local manufacturers and used without additional purification.

Shelukhina I.V., Zhmak M.N., Lobanov A.V., Ivanov I.A., Garifulina A.I., Kravchenko I.N., Rasskazova E.A., Salmova M.A., Tukhovskaya E.A., Rykov V.A., Slashcheva G.A., Egorova N.S., Muzyka I.S., Tsetlin V.I, & Utkin Y.N. (2018). Azemiopsin, a Selective Peptide Antagonist of Muscle Nicotinic Acetylcholine Receptor: Preclinical Evaluation as a Local Muscle Relaxant. Toxins, 10(1), 34.

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Fmoc-based Solid Phase Peptide Synthesis Protocol

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All protected AAs, Fmoc‐Rink amide MBHA resin, N‐(9‐fluorenylmethyloxycarbonyloxy)‐succinimide (Fmoc‐OSu), N,N‐dimethylformamide (DMF), 1‐methyl‐2‐pyrrolidinone (NMP), dichloromethane (DCM), diethylether (Et₂O), 2,2,2‐trifluoroethanol (TFE), and N,N‐diisopropylethylamine (DIPEA) were purchased from Iris Biotech GmbH (Marktredwitz, Germany). Pseudoproline dipeptides, O‐(7‐azabenzotriazol‐1‐yl)‐N,N,N′,N′‐tetramethyluronium‐hexafluorophosphate (HATU), H‐Gly‐2‐Cl‐trityl resin, H‐Thr(tBu)‐2‐Cl‐trityl resin, Fmoc‐Gly‐NovaSyn‐TGT resin, Fmoc‐Dbz‐NovaSyn‐TGR resin, 4‐nitrophenylchloroformate, and disodiumhydrogenphosphate were from Merck (Darmstadt, Germany). 1‐Hydroxybenzotriazole (HOBt), 2‐(1H‐benzotriazol‐1‐yl)‐1,1,3,3‐tetramethyluronium hexafluorophosphate (HBTU), N,N′‐diisopropylcarbodiimide (DIC), trifluoroacetic acid (TFA), and piperidine were obtained from Biosolve (Valkenswaard, The Netherlands). HPLC‐grade acetonitrile (ACN), thiophenol, 4‐mercaptophenylacetic acid (MPAA), triisopropylsilane (TIS), thioanisole (TIA), tris(2‐carboxyethyl) phosphine hydrochloride (TCEP), guanidine hydrochloride (GuHCl), and salicylaldehyde were obtained from Sigma Aldrich (Vienna, Austria). HPLC‐grade trifluoroacetic acid (TFA) was from Alfa‐Aesar (Karlsruhe, Germany).

Grassi L., Roschger C., Stanojlović V, & Cabrele C. (2018). An explorative study towards the chemical synthesis of the immunoglobulin G1 Fc CH3 domain. Journal of Peptide Science, 24(12), e3126.

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