C57b6 j wild type mice

All experiments were conducted in accordance with National Institutes of Health (NIH) Guide for the Care and Use of Laboratory Animals and approved by the Institutional Animal Care and Use Committee of the University of California, San Francisco (AN170302; AN184326). Male and female C57B6/J wild-type (WT) mice were received from Jackson Laboratories. Male CCR2^RFP/+ CX3CR1^GFP/+, male and female PV-CrexAi32 and male Thy-1-YFP-H (in C57 background) mice were bred inhouse. Mice were 3–5 months of age at the time of surgeries. Animal shipments were received at least one week prior to start of experimentation to allow animals to habituate to the new surroundings. Mice were group housed (by sexes and injury state) in environmentally controlled conditions with a reverse light cycle (12:12 h light: dark cycle at 21 ± 1 °C; ~50% humidity) and provided food and water ad libitum.