Xn 10 automated hematology analyzer

Manufactured by Sysmex

Sourced in Japan

The Sysmex XN-10 is an automated hematology analyzer designed for clinical laboratory use. It provides accurate and reliable analysis of various blood parameters, including red blood cells, white blood cells, and platelets. The XN-10 utilizes advanced technology to deliver efficient and consistent results, supporting healthcare professionals in their diagnostic and monitoring processes.

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Lab products found in correlation

Peloris 2, by Leica (2 mentions) H e automated strainers, by Sakura Finetek (2 mentions) Midas 3 stainer, by Thermo Fisher Scientific (2 mentions) Asp300, by Leica (2 mentions) Apex software 1, by Mabtech (1 mentions) Elispot kit, by Mabtech (1 mentions) Vivid 3, by GE Healthcare (1 mentions) Vivid 7, by GE Healthcare (1 mentions) Access pct, by Beckman Coulter (1 mentions) Innovance d dimer assay, by Siemens (1 mentions) Napsin a, by Biocare Medical (1 mentions)

Spelling variants of this product

Sysmex XN-10 (50 citations) Automated hematology analyzer (35 citations) Hematology analyzer (32 citations) XN-10 hematology analyzer (9 citations) XN hematology analyzer (9 citations) XN‐10 analyzer (3 citations) Sysmex automated analyzer (3 citations)

8 protocols using xn 10 automated hematology analyzer

Asthma Diagnosis and Biomarker Quantification

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Urine and plasma protein levels were quantified by BCA assay following methanol precipitation and metabolite extraction as described above (Section 4.2).
Classification of patients as asthmatic was performed by pediatric pulmonologists at the hospital during outpatient visits in the two-year period following enrollment in this study. Asthma diagnosis was based on responsiveness to bronchodilators following episodic symptoms of airflow obstruction or airway hyperresponsiveness, as standardized pulmonary function testing such as spirometry could not be performed in patients under 5 years of age [41 ].
White blood cell count values, including total WBC, lymphocytes, eosinophils and neutrophils were obtained from Complete Blood Count (CBC) tests performed on a Sysmex XN 10 Automated Hematology Analyzer as part of the routine care for inpatients.

Teoh S.T., Leimanis-Laurens M.L., Comstock S.S., Winters J.W., Vandenbosch N.L., Prokop J.W., Bachmann A.S., Lunt S.Y, & Rajasekaran S. (2022). Combined Plasma and Urinary Metabolomics Uncover Metabolic Perturbations Associated with Severe Respiratory Syncytial Viral Infection and Future Development of Asthma in Infant Patients. Metabolites, 12(2), 178.

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Comprehensive Stroke Patient Profiling

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Baseline demographic and clinical characteristics of the stroke patients were collected (Table 1 and Table 2, respectively). These included patient sex, age, body mass index (BMI), stroke type, and comorbidities. Laboratory data of fecal samples were also collected, including complete and differential blood counts using an XN-10 automated hematology analyzer (Sysmex, Kobe, Japan), erythrocyte sedimentation rate (ESR) using a TEST 1 automated analyzer (Alifax, Padova, Italy), and serum levels of glucose, creatinine, total protein (TP), albumin, aspartate transaminase (AST), alanine transaminase (ALT), and C-reactive protein (CRP) using a Cobas 8000 c702 automated analyzer (Roche Diagnostics, Basel, Switzerland). The laboratory characteristics are summarized in Table 3.

Park S.Y., Lee S.P, & Kim W.J. (2021). Fecal Calprotectin Is Increased in Stroke. Journal of Clinical Medicine, 11(1), 159.

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SARS-CoV-2 T-cell Response Evaluation

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T-cell response was evaluated at four weeks after first dose and at two weeks after the second vaccine dose using human interferon gamma (IFN-γ) ELISpot kit (Mabtech, Nacka Strand, Sweden) according to manufacturer instructions. Briefly, peripheral blood mononuclear cells (PBMCs) were counted using an automated cell counter (Sysmex XN-10™ Automated Hematology Analyzer). ELISpot plates were blocked for 30 min with 10% FCS containing RPMI media prior to the addition of 250,000 PBMCs/well. The stimulation solutions were S-peptide consisting of 100 peptides from spike protein, and NMO-peptide pools consisting of 101 peptides from nucleocapsid (N), membrane (M), open reading frame (ORF) 1, non-structural protein (nsp) 3, ORF-3a, ORF-7a, and ORF8 proteins. ELISpot plates were then incubated for 20 hours at 37°C and 5% CO2, washed and developed using a conjugated secondary antibody that bound to membrane-captured IFN-γ. The plates were read using IRIS (Mabtech) and spots were analyzed using Apex software 1.1 (Mabtech) and converted to spot-forming units (SFU) per million cells.

Chatsiricharoenkul S., Niyomnaitham S., Posen H.J., Toh Z.Q., Licciardi P.V., Wongprompitak P., Duangchinda T., Pakchotanon P., Chantima W, & Chokephaibulkit K. (2022). Safety and immunogenicity of intradermal administration of fractional dose CoronaVac®, ChAdOx1 nCoV-19 and BNT162b2 as primary series vaccination. Frontiers in Immunology, 13, 1010835.

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Venous Blood Analysis and Echocardiography in PCI

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Venous blood samples were drawn from antecubital veins immediately after obtaining ECG. Whole blood counting parameters were analyzed by a Sysmex K-1000 and Sysmex XN-10 Automated Hematology Analyzer (Sysmex Corporation, Kobe, Japan) autoanalyzer within 5 min of blood sampling. Whole blood sample collected in tripotassium ethylenediamineteteraacetic acid (EDTA) (7.2 mg) tubes. In all study participants transthoracic echocardiography was performed before primary PCI in the coronary care unit. Estimated glomerular filtration rate (eGFR) was calculated using with the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI). All echocardiographic measurements were made using commercially available devices (Vivid 3 ® and Vivid 7 ® , GE Medical System, Horten, Norway) with a 3.5-MHz transducer. To evaluate left ventricular ejection fraction (LVEF) the Simpson's method was used [17] .

Celık T., Balta S., Demır M., Yıldırım A.O., Kaya M.G., Ozturk C., Demırkol S., Unlu M., Kılıc S., Aydın İ, & Iyısoy A. (2016). Predictive value of admission red cell distribution width-platelet ratio for no-reflow phenomenon in acute ST segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Cardiology journal, 23(1).

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Comprehensive Hematology and Biochemistry Profiling

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Complete blood counts and biochemical parameters of the patients were measured.
Complete blood counts were analyzed using a Sysmex XN-10 Automated Hematology
Analyzer (XN series, Sysmex Corporation, Kobe, Japan) according to the
manufacturer’s instructions. Serum procalcitonin levels were measured with a
Unicel-DXI (Beckman Coulter Inc., Brea, CA, USA) using a commercial
chemiluminescence immunoassay test kit (Access PCT; Beckman Coulter Inc.). 25-OH
vitamin D and parathormone levels were measured using a Beckman Coulter Unicell
DXI 800 immunoassay analyzer (Beckman Coulter Inc.) with commercial
chemiluminescence immunoassay kits supplied or validated by the manufacturer.
Other biochemical parameters were measured using a Beucher Coulter AU 5800
(Beckman Coulter GmbH, Krefeld, Germany) with commercial test kits produced or
validated by the manufacturer.
Serum creatinine, lactate, phosphorus, calcium, and albumin levels were analyzed
using standardized laboratory procedures. Serum procalcitonin levels were
measured using an immunoluminometric assay, and C-reactive protein levels were
measured using nephelometry. Serum parathyroid hormone levels were measured by
immunoradiometric assays, and 25-OH vitamin D levels were measured by
chemiluminescent immunoassay.

Erdoğan M, & Fındıklı H.A. (2021). Novel biomarker for predicting sepsis mortality: vitamin D receptor. The Journal of International Medical Research, 49(8), 03000605211034733.

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Venous Blood Collection and Plasma Preparation

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Venous blood samples were collected at baseline from all participants using a 21-gauge needle. The blood was drawn into 3.5-mL VACUETTE 9NC coagulation 3.2% trisodium citrate (0.109 mol/L) tubes (Greiner Bio-One). All tubes were kept in a vertical position with no agitation during transportation to the laboratory. The samples were processed within 2 hours of extraction. Platelet-poor plasma (PPP) was obtained by centrifugation, as our group described previously.^{19 (link)} In brief, the samples underwent centrifugation at 1500g for 30 minutes at 4 °C, with no brake application. The resulting PPP was then collected and stored at –80 °C for future use. The levels of D-dimer and sP-selectin in the PPP of both the case and control groups were measured using commercially available kits. The INNOVANCE D-Dimer Assay (Siemens Healthineers) was used to measure D-dimer, with a lower detection limit of 0.19 mg/L fibrinogen-equivalent units. For sP-selectin, the Human sP-selectin/CD62P Immunoassay (R&D Systems) was used according to the manufacturer’s guidelines. The results were expressed as µg/L for D-dimer and ng/mL for sP-selectin, respectively. The assessment of blood cell count, platelets, and hemoglobin levels was performed using standardized clinical laboratory procedures with a Sysmex XN-10 Automated Hematology Analyzer (Sysmex).

Sánchez-López V., Marín-Romero S., Ferrer-Galván M., Elías-Hernández T., Lobo Beristain J.L., Ballaz Quincoces A., Jara-Palomares L., Rodríguez Martorell F.J., Castro M.J., Marín Hinojosa C., López-Campos J.L, & Otero-Candelera R. (2024). Occult cancer in patients with unprovoked venous thromboembolism: A nested case-control study. American Journal of Clinical Pathology, 161(5), 501-511.

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Bone Marrow Histopathological Assessment

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Bone marrow aspirate and biopsy specimens were processed using the automated tissue processors Leica ASP300S and Leica Peloris II (Leica Biosystems Division of Leica Microsystems Inc.). Three micron-section tissue slides were cut from the processed paraffin blocks and stained with hematoxylin and eosin (H&E) using H&E automated strainers (Sakura Finetek USA; Leica Biosystems, Division of Leica Microsystems). Morphologic assessment of the H&E-stained specimens was performed by a board-certified hematopathologist. Wright–Giemsa stain was performed on peripheral blood sample with the Midas III Stainer (Fisher Scientific, Part of Thermo Fisher Scientific; Sysmex America, Inc.; Sigma-Aldrich). Complete blood count (CBC) was performed on a Sysmex XN-10 Automated Hematology Analyzer (Sysmex America) and followed with a manual differential.

El Hussein S., Evans A.G., Fitzsimmons J.M., Leong N., Buldo M., Segal J.P., Jajosky A.N., Rothberg P.G., Liesveld J.L, & Oltvai Z.N. (2023). Clonal cytopenia of undetermined significance (CCUS)-associated reversion of donor-derived, transient αβ T-cell large granular clonal lymphocytosis, emerging post-transplant in a patient with a history of γδ T-cell large granular lymphocytic leukemia. Cold Spring Harbor Molecular Case Studies, 9(2), a006241.

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EBUS-Guided FNA Specimen Processing

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EBUS-guided FNA specimen was processed by the direct smear method, fixed with 95% ethanol for 15 min prior to processing. The specimens were then processed using the automated tissue processors Leica ASP300S and Leica Peloris II (Leica Biosystems Division of Leica Microsystems Inc.). Three micron-section tissue slides were cut from the processed paraffin blocks and stained with hematoxylin and eosin (H&E) using H&E automated strainers (Sakura Finetek, Inc.; Leica Biosystems, Division of Leica Microsystems Inc.). Immunohistochemical stains were performed as follows: TTF-1 (Agilent), Napsin A (Biocare Medical; Agilent), P40 (Biocare Medical; Leica Biosystems, Division of Leica Microsystems Inc.), and PD-L1 22c3 (Agilent). Morphologic assessment of the H&E-stained FNA biopsy specimens, as well as interpretation of immunohistochemical stains, was performed by a board-certified anatomic pathologist. Wright–Giemsa stain was performed on peripheral blood sample with Midas III Stainer (Fisher Scientific, Part of Thermo Fisher Scientific; Sysmex America, Inc.; Sigma-Aldrich, Inc.). Complete blood count (CBC) was performed on a Sysmex XN-10 Automated Hematology Analyzer (Sysmex America, Inc.) and followed with a manual differential.

Nkosi D., Miller C.A., Jajosky A.N, & Oltvai Z.N. (2022). Incidental discovery of acute myeloid leukemia during liquid biopsy of a lung cancer patient. Cold Spring Harbor Molecular Case Studies, 8(4), a006201.

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