Rocuronium bromide

Manufactured by Fresenius

Sourced in Germany

Rocuronium Bromide is a neuromuscular blocking agent used in medical settings. It is a non-depolarizing muscle relaxant that temporarily paralyzes skeletal muscles by blocking the action of acetylcholine at the neuromuscular junction. This product is primarily used to facilitate endotracheal intubation and provide muscle relaxation during surgical procedures.

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Lab products found in correlation

Normal saline, by Merck Group (1 mentions) Tentagel s ram, by Rapp Polymere (1 mentions) N n diisopropylethylamine dipea, by Iris Biotech (1 mentions) Rocuronium, by Fresenius (1 mentions) Morphine sulfate, by Pfizer (1 mentions) Desflurane, by Baxter (1 mentions)

2 protocols using rocuronium bromide

Synthesis of Polystyrene-PEG Block Copolymer Resin

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A polystyrene-poly(ethylene glycol) 2000 block-copolymer resin, modified with Knorr linker Tentagel S RAM was from Rapp Polymere GmbH (Tübingen, Germany). Fmoc-protected amino acids, 4-methyl piperidine were from Mosinter (Ningbo, China). 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate (HATU), 1-Hydroxy-7-azabenzotriazole (HOAt) and DL-Dithiothreitol (DTT) were from DEMO Medical (Shanghai, China). N,N-diisopropylethylamine (DIPEA) was from Iris Biotech GmbH (Marktredwitz, Germany), trifluoroacetic acid from Solvay S.A. (Bruxelles, Belgium), normal saline (sterile 0.9% NaCl solution), complete Freund’s adjuvant and trinitrobenzenesulfonic acid (TNBS) from Sigma-Aldrich Chemie Gmbh (Munich, Germany), bovine serum albumin (BSA) from Amresko, Rocuronium Bromide from Fresenius Kabi (Bad Homburg, Germany). All other reagents and solvents of the highest purity available were purchased from local manufacturers and used without additional purification.

Shelukhina I.V., Zhmak M.N., Lobanov A.V., Ivanov I.A., Garifulina A.I., Kravchenko I.N., Rasskazova E.A., Salmova M.A., Tukhovskaya E.A., Rykov V.A., Slashcheva G.A., Egorova N.S., Muzyka I.S., Tsetlin V.I, & Utkin Y.N. (2018). Azemiopsin, a Selective Peptide Antagonist of Muscle Nicotinic Acetylcholine Receptor: Preclinical Evaluation as a Local Muscle Relaxant. Toxins, 10(1), 34.

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Multimodal Perioperative Anesthesia Protocol

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General anesthesia was induced using propofol (1–3 mg/kg of TBW; 1%-emulsion, Fresenius Kabi, Lake Zurich, IL, USA), fentanyl (fentanyl citrate, Hospira, Lake Forest, IL, USA), and succinylcholine (1mg/kg per TBW; succinylcholine chloride, Hospira). Maintenance of anesthesia was achieved with desflurane (Baxter) and rocuronium (rocuronium bromide, Fresenius Kabi). The induction dose of fentanyl was administered based on lean body weight (1–2 mcg per kg). Postoperative analgesia was provided by 2–3 mg morphine only as needed (morphine sulfate, Hospira), 1000 mg acetaminophen (every 8 hours), and 30 mg ketorolac (every 8 hours), each prescribed around the clock and administered intravenously. Ondansetron (4–6 mg) was also given continuously every four to six hours for anti-emesis.

Williams E.F., Vaughns J.D., Mackey E.R., Muret J.C., Nadler E.P, & van den Anker J.N. (2020). Implications of Perioperative Polypharmacy in Adolescents Undergoing Bariatric Surgery - A Single Center Experience. Obesity surgery, 30(7), 2832-2835.

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