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Raptorfl fl

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Raptorfl/fl is a laboratory equipment product. It is a tool used for research purposes, but a detailed description of its core function cannot be provided while maintaining an unbiased and factual approach. Additional information or interpretation of its intended use is not available.

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Lab products found in correlation

Rictorfl fl, by Jackson ImmunoResearch (3 mentions) Lysm cre, by Jackson ImmunoResearch (2 mentions) Il1r1 mice, by Jackson ImmunoResearch (2 mentions) C57bl 6 wt, by Jackson ImmunoResearch (2 mentions) Raptorfl fl mice, by Jackson ImmunoResearch (2 mentions) Hcd2 cre mice, by Jackson ImmunoResearch (2 mentions) Il 23r ko mice, by Gene Tech (2 mentions) Rictorfl fl mice, by Jackson ImmunoResearch (2 mentions) Stat3fl fl, by Jackson ImmunoResearch (2 mentions) Mtorfl fl, by Jackson ImmunoResearch (1 mentions)

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Raptorfl/fl mice (8 citations)

4 protocols using raptorfl fl

1

Transgenic Mouse Models for Tumor Research

Cited 2 times
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PyMT transgenic, mTORfl/fl, Raptorfl/fl, LysM-Cre and DTASTOP85 (link) mouse was bought from Jackson Laboratory (stock number 002374). The Ncr1-Cre transgenic mouse was designed as previous described.64 (link) PDK1fl/fl mouse was kindly provided by D. Alessi, University of Dundee, Dundee, Scotland, UK. All mice were bred and maintained in specific pathogen-free animal facilities and all procedures involving animals were approved by the Animal Ethics Committee of Tsinghua University.
He Y., Du J, & Dong Z. (2020). Myeloid deletion of phosphoinositide-dependent kinase-1 enhances NK cell-mediated antitumor immunity by mediating macrophage polarization. Oncoimmunology, 9(1), 1774281.
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2

Genetically Engineered Mouse Models for Immunology Research

Cited 1 time
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C57BL/6 WT, MyD88−/− and Il1r1−/− mice on C57BL/6 background were purchased from the Jackson Laboratory. IL-23R KO mice were imported from Genetech. hCD2-Cre mice (Jackson Laboratory) were crossed with Raptorfl/fl mice, Rictorfl/fl mice (Jackson Laboratory) and Stat3fl/fl mice (Ding et al., 2016 (link)) to generate CD2-cre;Raptorfl/fl, CD2-cre;Rictorfl/fl and CD2-cre;Stat3fl/fl conditional KO (cKO) mice. Male and female mice were used in all experiments (6–12 weeks old) and were housed in specific pathogen free conditions. All experiments were in accordance with institutional guidelines and approved by the IACUC at the University of Louisville.
Cai Y., Xue F., Qin H., Chen X., Liu N., Fleming C., Hu X., Zhang H.G., Chen F., Zheng J, & Yan J. (2019). Differential Roles of the mTOR-STAT3 Signaling in Dermal γδ T Cell Effector Function in Skin Inflammation. Cell reports, 27(10), 3034-3048.e5.
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3

Genetically Engineered Mouse Models for Immunology Research

Cited 1 time
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C57BL/6 WT, MyD88−/− and Il1r1−/− mice on C57BL/6 background were purchased from the Jackson Laboratory. IL-23R KO mice were imported from Genetech. hCD2-Cre mice (Jackson Laboratory) were crossed with Raptorfl/fl mice, Rictorfl/fl mice (Jackson Laboratory) and Stat3fl/fl mice (Ding et al., 2016 (link)) to generate CD2-cre;Raptorfl/fl, CD2-cre;Rictorfl/fl and CD2-cre;Stat3fl/fl conditional KO (cKO) mice. Male and female mice were used in all experiments (6–12 weeks old) and were housed in specific pathogen free conditions. All experiments were in accordance with institutional guidelines and approved by the IACUC at the University of Louisville.
Cai Y., Xue F., Qin H., Chen X., Liu N., Fleming C., Hu X., Zhang H.G., Chen F., Zheng J, & Yan J. (2019). Differential Roles of the mTOR-STAT3 Signaling in Dermal γδ T Cell Effector Function in Skin Inflammation. Cell reports, 27(10), 3034-3048.e5.
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4

Genetic Manipulation of Myeloid Cells

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The mice with the myeloid deletion of PDK1 was achieved by crossing PDK1fl/fl to LysM-Cre purchased from the Jackson Laboratory. Raptorfl/fl and Rictorfl/fl mice were purchased from the Jackson Laboratory. This line was backcrossed with C57BL/B6 mice for at least 8 generations before use in subsequent experiments, and all mice in the present study were the background of C57BL/6. All mice were at the age of 6–12 weeks and were randomly divided into different groups. The mice were bred and maintained in specific pathogen-free animal facilities, and all procedures involving animals were approved by the Animal Ethics Committee.
Du J., Li G., Hua M., Han J., Hao Y., Zeng H., Li A, & Kong Y. (2020). PDK1/mTOR Signaling in Myeloid Cells Differentially Regulates the Early and Late Stages of Sepsis. Mediators of Inflammation, 2020, 5437175.
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