Foxn1cre

All mouse experiments were approved by the Institutional Animal Care and Use Committee of Carnegie Institution for Science. Lmnb1^f/f allele was derived from Lmnb1^{tm1a(EUCOMM)Wtsi} by the EUCOMM project. The conditional Lmnb2 allele, Lmnb2^f/f, was derived from Lmnb2^{tm1a(KOMP)Wtsi} (KOMP project) by breeding with ACTB‐FLPe mice to remove neomycin cassette flanked by Frt sites. Lmna^f/f and Lmnb1^−/− alleles were generated in house by Dr. Youngjo Kim and were reported previously (Kim & Zheng, 2013). All mice were further backcrossed to the C57BL/6 background for at least 6 generations. LckCre, Foxn1Cre, K5CreET^T2, K8CreER^T2, and OT‐II mice were purchased from the Jackson Laboratory. K5CreET^T2 and K8CreER^T2 mice were further backcrossed to the C57BL/6 background for at least 2 generations. 20‐mon‐old female C57BL/6 mice were purchased from National Institution on Aging. Other mice in cohort experiments at the indicated ages were raised by the mouse facility of Carnegie Institution for Science. All animals were housed under a 12‐/12‐hr light–dark cycle and fed ad libitum.