The surgical procedure for DBS lead and pulse generator implantation followed published methods.11 (link),12 (link),14 (link) Extending a previously described frame-based, stereotaxic anatomical localization protocol whereby the grey-white matter junction at the mid-subcallosal cingulate region is identified on high resolution T1 MRI structural images,11 (link),14 (link) target selection for this patient cohort also utilized an individualized pre-operative deterministic tractography map identifying the location of the intersection of 4 white matter bundles recently shown necessary for effective antidepressant effects.26 (link) The combined tractography and anatomical images guided standard localization of the DBS lead tip and trajectory using a surgical planning workstation (Stealth, Medtronic Inc). Bilateral DBS leads (Libra system, St Jude Medical, Plano, TX), each with 4 contacts (1.5 mm inter-contact spacing) were placed and secured and with the patient awake and alert, testing was initiated.
Libra system
Manufactured by Abbott
The Libra system is an automated clinical chemistry analyzer designed for high-volume diagnostic laboratories. It is capable of performing a wide range of clinical chemistry tests, including colorimetric, enzyme, and immunoassay analyses. The Libra system is intended for use in the in vitro diagnostic testing of patient samples.
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Lab products found in correlation
4 protocols using libra system
1
Stereotactic DBS Lead Implantation Protocol
2
Surgical Procedure for Deep Brain Stimulation
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The surgical procedure for DBS lead and pulse generator implantation followed published methods (15 (link)). The combined tractography and anatomical images guided standard localization of the DBS lead tip and trajectory using a surgical planning workstation (StealthStation S7, Medtronic Inc, Louisville, CO). Bilateral DBS leads (Libra system, St Jude Medical, Plano, TX), each with 4 contacts (1.5 mm inter-contact spacing) were inserted and secured and with the patient awake and alert for testing initiated thereafter. Placement of the implantable pulse generator (IPG) and extension cables was performed under general anesthesia following completion of intra-operative testing.
3
Implantable Deep Brain Stimulation for Essential Tremor
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Example 1
The system of the invention can be used to assist a person or subject having essential tremor. Totally Implantable Deep Brain Stimulation System in the ventral intermediate (VIM) nucleus of the thalamus can be implanted for the treatment of tremor due to essential tremor (e.g., the Libra System in the St. Jude Medical Deep Brain Stimulation System).
One or more sensing devices can be used to monitor action tremor, resting tremor, and daily movements. Each of the one or more sensing devices can include an accelerometer.
The one or more sensing devices are skin-coupled to the top of wrist, forearm, and top surface of hand. The device is in low power mode with accelerometer sensor set to detect tremors (3-10 Hz oscillations of the hand) based on set features (frequency and amplitude) while the subject is going about daily activity. Tremors, daily movements, and resting tremor are all catalogued by the sensor for 24-72 hours of continuous monitoring. Once the at least one sensing device is synced with an external smart device via Bluetooth low energy, this tremor information and duration of time the patient experienced tremors is all uploaded to the cloud where it is related to other sensor information collected from other sensing devices or to phone data collected about GPS, weather conditions, calendar activities, medication schedule, etc. for more in depth analytics.
4
Surgical Procedure for Deep Brain Stimulation
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