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Dextomitor

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Dextomitor is a veterinary laboratory equipment product manufactured by Zoetis. It is a device used for the administration of dexmedetomidine, a potent and selective alpha-2 adrenoceptor agonist, which is a commonly used sedative and analgesic agent in animal patients.

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Lab products found in correlation

Carprofen, by Zoetis (4 mentions) 1.7mm 30 degree scope, by Storz (2 mentions) 22 guage spinal needle, by BD (2 mentions) Nasopore, by Stryker (1 mentions)

4 protocols using dextomitor

1

Rabbit Model for Pathogenesis Study

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This study was approved by the Institutional Animal Care and Use Committee (IACUC Approval number 21687) at the University of Alabama at Birmingham (UAB). Pasteurella-free, female, New Zealand white rabbits (2–4 kg) were used for the study. Before initiation, rabbits were acclimatized to the animal facility for at least 1 week. For any procedure, rabbits were anesthetized with [ketamine (20 mg/kg) (MWI, Boise, ID), dextomitor (0.25 mg/kg) (Zoetis Inc., Kalamazoo, MI), buprenorphine (0.03 mg/kg) (Reckitt Benckiser Pharmaceuticals Inc., Richmond, VA), and carprofen (5 mg/kg) (Zoetis Inc., Kalamazoo, MI)] in a warm room for comfort. Rabbits did not receive any antibiotics before or during this study.
Cho D.Y., Skinner D., Hunter R.C., Weeks C., Lim D.J., Thompson H., Walz C.R., Zhang S., Grayson J.W., Swords W.E., Rowe S.M, & Woodworth B.A. (2020). Contribution of Short Chain Fatty Acids to the Growth of Pseudomonas aeruginosa in Rhinosinusitis. Frontiers in Cellular and Infection Microbiology, 10, 412.
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2

Rabbit Model of Sinusitis: Inoculation and Evaluation

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This study was approved by the institutional animal care and use committee (IACUC) at the University of Alabama at Birmingham. Pasteurella-free, female, New Zealand white rabbits (3–4 kg) were used for the study. Before study initiation, rabbits were acclimatized to the animal facility for at least 1 week. Rabbits were anesthetized with [ketamine (20 mg/kg) (MWI, Boise, ID), dextomitor (0.25 mg/kg) (Zoetis Inc., Kalamazoo, MI), buprenorphine (0.03 mg/kg) (Reckitt Benckiser Pharmaceuticals Inc., Richmond, VA), and carprofen (5 mg/kg) (Zoetis Inc., Kalamazoo, MI)] in a warm room. No rabbits were intubated or provided any inhalational anesthetic agents. Nasal endoscopy (1.7mm 30-degree scope, Karl Storz, Tuttlingen, Germany) was performed bilaterally to exclude pre-existing infection or abnormal lesions. A synthetic sponge (Merocel ®, Medtronics, FL) was inserted into the middle meatus to occlude the maxillary sinus outflow tract. The ipsilateral maxillary sinus was inoculated directly into the maxillary sinus laterally with 0.5 mL of wild-type P. aeruginosa (PAO-1) using a 22-guage spinal needle (Becton-Dickinson, Franklin Lakes, NJ). The concentration was adjusted to an OD600 = 0.6 in sterile saline (4.0 × 108 colony forming units (CFUs)).
Lim D.J., McCormick J., Skinner D., Zhang S., Elder J.B., Mclemore J.G., Allen M., West J.M., Grayson J.W., Rowe S.M., Woodworth B.A, & Cho D.Y. (2019). CONTROLLED DELIVERY OF CIPROFLOXACIN AND IVACAFTOR VIA SINUS STENT IN A PRECLINICAL MODEL OF PSEUDOMONAS SINUSITIS. International forum of allergy & rhinology, 10(4), 481-488.
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3

Anesthetic Protocol for Rabbit Study

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This study was approved by the Institutional Animal Care and Use Committee (IACUC) at the University of Alabama at Birmingham (UAB). Pasteurella-free, female, New Zealand white rabbits (2–4 kg) were used for the study. Before initiation, rabbits were acclimatized to the animal facility for at least 1 week. For any procedure, rabbits were anesthetized with [ketamine (20 mg/kg) (MWI, Boise, ID), dextomitor (0.25 mg/kg) (Zoetis Inc., Kalamazoo, MI), buprenorphine (0.03 mg/kg) (Reckitt Benckiser Pharmaceuticals Inc., Richmond, VA), and carprofen (5 mg/kg) (Zoetis Inc., Kalamazoo, MI)] in a warm room for comfort. Rabbits did not receive any antibiotics before or during this study.
Cho D.Y., Mackey C., Van Der Pol W.J., Skinner D., Morrow C.D., Schoeb T.R., Rowe S.M., Swords W.E., Tearney G.J, & Woodworth B.A. (2018). Sinus Microanatomy and Microbiota in a Rabbit Model of Rhinosinusitis. Frontiers in Cellular and Infection Microbiology, 7, 540.
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4

Induction of Experimental Sinusitis in Rabbits

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This study was approved by the institutional animal care and use committee (IACUC) at the University of Alabama at Birmingham. Pasteurella-free, female, New Zealand white rabbits (2–4 kg) were used for the study. Before study initiation, rabbits were acclimatized to the animal facility for at least 1 week. Rabbits were anesthetized with [ketamine (20 mg/kg) (MWI, Boise, ID), dextomitor (0.25 mg/kg) (Zoetis Inc., Kalamazoo, MI), buprenorphine (0.03 mg/kg) (Reckitt Benckiser Pharmaceuticals Inc., Richmond, VA), and carprofen (5 mg/kg) (Zoetis Inc., Kalamazoo, MI)] in a warm room. No rabbits were intubated or provided any inhalational anesthetic agents. Nasal endoscopy (1.7mm 30-degree scope, Karl Storz, Tuttlingen, Germany) was performed bilaterally to exclude pre-existing infection or abnormal lesions. A polyurethane glycol dressing (2 cm NasoPore ®,Stryker, Kalamazoo, MI) was inserted into the middle meatus to occlude the maxillary sinus outflow tract. The ipsilateral maxillary sinus was transnasally inoculated through the medial wall of the maxillary sinus (in front of the middle turbinate) with 0.5 mL of wild-type P. aeruginosa (PAO-1) using a 22-guage spinal needle (Becton-Dickinson, Franklin Lakes, NJ) (Figure 2A). The concentration was adjusted to an OD600 = 0.6 in sterile saline (4.0 × 108 (link) colony forming units (CFUs)).
Cho D.Y., Lim D.J., Mackey C., Skinner D., Weeks C., Gill G.S., Hergenrother Ph.D. R.W., Swords Ph.D. W.E, & Woodworth B.A. (2018). Preclinical Therapeutic Efficacy of the Ciprofloxacin-eluting Sinus Stent for Pseudomonas Aeruginosa Sinusitis. International forum of allergy & rhinology, 8(4), 482-489.
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