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Tiagabine

Manufactured by Bio-Techne
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Tiagabine is a laboratory instrument used for the detection and quantification of the drug tiagabine in various biological samples. It is a high-performance liquid chromatography (HPLC) system designed to provide accurate and reliable results for researchers and clinicians.

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Lab products found in correlation

Vigabatrin, by Bio-Techne (2 mentions) Bicuculline, by Abcam (2 mentions)

2 protocols using tiagabine

1

Pharmacological Modulation of GABA Signaling

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NG2DsRed mice received daily intraperitoneal (i.p.) injections (from P5-P11 or from P11-P15) of either 1 mg/kg bicuculline (abcam) in sunflower seed oil (Sigma 47123), 100 mg/kg vigabatrin in saline or 50 mg/kg tiagabine in saline (Tocris Biosciences). Control mice were injected with vehicle alone. Injection volume was 10 μl per g body weight, and solutions were warmed to 37 °C. The dose of bicuculline used was roughly half the CD50 reported for P7 rats69 (link); two mice exhibited seizures and were excluded from the study.
Zonouzi M., Scafidi J., Li P., McEllin B., Edwards J., Dupree J.L., Harvey L., Sun D., Hübner C.A., Cull-Candy S.G., Farrant M, & Gallo V. (2015). GABAergic regulation of cerebellar NG2-cell development is altered in perinatal white matter injury. Nature neuroscience, 18(5), 674-682.
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2

Pharmacological Modulation of GABA Signaling

Check if the same lab product or an alternative is used in the 5 most similar protocols
NG2DsRed mice received daily intraperitoneal (i.p.) injections (from P5-P11 or from P11-P15) of either 1 mg/kg bicuculline (abcam) in sunflower seed oil (Sigma 47123), 100 mg/kg vigabatrin in saline or 50 mg/kg tiagabine in saline (Tocris Biosciences). Control mice were injected with vehicle alone. Injection volume was 10 μl per g body weight, and solutions were warmed to 37 °C. The dose of bicuculline used was roughly half the CD50 reported for P7 rats69 (link); two mice exhibited seizures and were excluded from the study.
Zonouzi M., Scafidi J., Li P., McEllin B., Edwards J., Dupree J.L., Harvey L., Sun D., Hübner C.A., Cull-Candy S.G., Farrant M, & Gallo V. (2015). GABAergic regulation of cerebellar NG2-cell development is altered in perinatal white matter injury. Nature neuroscience, 18(5), 674-682.
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