Anhydrous glycerol

The triglyceride trimyristin (Dynasan^® 114) was donated by IOI Oleo, Witten, Germany and the surfactant poloxamer 407 (Kolliphor^® P127) by BASF AG, Ludwigshafen, Germany. Sodium alginate (Manugel^® GMB) was a kind gift from FMC International, Wallingstown, Ireland. As estimated by the supplier, the molecular weight was ~124 kDa, the content of guluronic acid (G) was 60–70% and that of mannuronic acid (M) was 30–40%. Tetrahydrofuran (HPLC grade), acetonitrile (HPLC grade), and the drugs fenofibrate and retinyl acetate were obtained from Sigma-Aldrich, Steinheim, Germany. Cannabidiol was purchased from TCH-Pharma, Frankfurt, Germany. Lumefantrine was purchased from Acros Organics, Geel, Belgium. Orlistat was donated by Formosa Laboratories Inc., Taoyuan, Taiwan. Refined rapeseed oil, sodium hydroxide, sodium azide, anhydrous glycerol, calcium chloride, acetonitrile (LC-MS grade), and tetrahydrofuran (Ultra LC-MS grade) were obtained from Carl Roth, Karlsruhe, Germany. All materials were used as received. Purified water was prepared by deionization and filtration (EASYpureTM LF, Barnstead, Dubuque, IA, USA) or was of bidistilled quality.

The triglyceride trimyristin (Dynasan^® 114) was donated by IOI Oleo, Witten, Germany, and the surfactant poloxamer 407 (Kolliphor^® P127) by BASF AG, Ludwigshafen, Germany. Sodium alginate (Manugel^® GMB) was a kind gift from FMC International, Wallingstown, Ireland. As estimated by the supplier, the molecular weight was ~124 kDa, the content of guluronic acid was 60–70%, and that of mannuronic acid was 30–40%. Cholesteryl nonanoate was purchased from TCI, Zwijndrecht, Belgium. tetrahydrofuran (HPLC grade), acetonitrile (HPLC grade), bovine serum albumin (BSA, heat shock fraction, pH 7, ≥98%), and the drugs fenofibrate and retinyl acetate were obtained from Sigma-Aldrich, Steinheim, Germany. Orlistat was donated by Formosa Laboratories Inc., Taoyuan, Taiwan. Sodium azide, anhydrous glycerol, calcium chloride, acetonitrile (LC MS grade), and tetrahydrofuran (ultra LC MS grade) were obtained from Carl Roth, Karlsruhe, Germany. All materials were used as received. Water was purified by deionization and filtration (EASYpureTM LF, Barnstead, Dubuque, IA, USA) or was of bidistilled quality. The logP values of the drugs were obtained from DrugBank (calculated by ALOGPS).