Methocel k4m

Manufactured by Colorcon

Sourced in United Kingdom

Methocel K4M is a cellulose-based polymer that functions as a binder, thickener, and film-forming agent in pharmaceutical and food applications. It is a white to off-white, granular powder that is soluble in water and other polar solvents. The specific viscosity of Methocel K4M can be adjusted through manufacturing parameters.

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Methocel (5 citations) Methocel™ K4M Premium CR (3 citations) HPMC (Methocel K4M) (2 citations)

8 protocols using methocel k4m

Formulation and Characterization of Nimesulide

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Nimesulide was gifted from PharmEvo Pakistan. Microcrystalline cellulose (Avicel PH102) and carboxymethylcellulose (Ac-di-sol®) were purchased from FMC, Brussels, Belgium. Octadecanoic acid, magnesium stearate, and sodium lauryl sulphate were purchased from RDH Germany. Hydroxypropyl methylcellulose (Methocel K4M) was gifted from Colorcon, USA. Potassium dihydrogen phosphate, Hydrochloric acid, Sodium hydroxide, Sodium Chloride, sodium taurocholate, citric acid, lecithin, disodium hydrogen Phosphate, Triton X 100, sodium dihydrogen phosphate, glacial acetic acid, Sodium hydroxide pellets, citric acid, ammonium acetate and HPLC grade, all were purchased from Merck, Darmstadt, Germany.

Hanif M., Shoaib M.H., Yousuf R.I, & Zafar F. (2018). Development of in vitro - in vivo correlations for newly optimized Nimesulide formulations. PLoS ONE, 13(8), e0203123.

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Biodegradable PLA filament for drug-loaded hydrogels

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Polylactic acid (PLA) was chosen as biodegradable thermoplastic printer filament for FDM (melting point 220ºC, density 1.25 g/cm 3 ), supplied by Leon3D (Spain). Hydroxypropyl methylcellulose METHOCEL™ K4M (Colorcon Ltd., UK) was used as hydrophilic polymer to prepare drug-loaded hydrogels for IVF. Anhydrous theophylline (Acofarma, Spain) has been used as a model drug. Eudragit FS30D (Evonik, Germany) was chosen as delaying release polymer.

Linares V., Casas M, & Caraballo I. (2019). Printfills: 3D printed systems combining fused deposition modeling and injection volume filling. Application to colon-specific drug delivery. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 134.

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Glipizide HPMC Polymer Formulations

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Glipizide was used as the model drug and purchased from TCI Europe (Zwijndrecht, Belgium). HPMC polymer of different grades with increasing molecular size/weight (Methocel® K4M, K15M and K100M) was kindly provided by Colorcon Ltd (Dartford, UK). Specifications of different HPMC grades are listed in Table 1.

Khizer Z., Akram M.R., Sarfraz R.M., Nirwan J.S., Farhaj S., Yousaf M., Hussain T., Lou S., Timmins P., Conway B.R, & Ghori M.U. (2019). Plasticiser-Free 3D Printed Hydrophilic Matrices: Quantitative 3D Surface Texture, Mechanical, Swelling, Erosion, Drug Release and Pharmacokinetic Studies. Polymers, 11(7), 1095.

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Formulation and Evaluation of Solid Dosage Forms

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Methocel K4M (Colorcon Ltd.), Carbopol 974P (Lubrizol), Cremophor EL (Gattefosse), Solutol HS15 (Gattefosse), Transcutol P (Gattefosse), Aerosil 200 (Evonik), Hard gelatin capsules (ACG capsules) were obtained as gift samples. Mannitol, Magnesium stearate, Tween 80, PEG 400 and sodium alginate were purchased from SD Fine Chemicals Ltd. All other reagents and chemicals were of AR grade.

Phadatare A.G., Viswanathan V, & Mukne A. (2014). Novel strategies for optimized delivery of select components of Allium sativum. Pharmacognosy Research, 6(4), 334-340.

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Formulation and Characterization of Ibuprofen Delivery

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Ibuprofen (IBU) was purchased from Farmasino Pharmaceuticals Co. Ltd. (Jiangsu, China). Pharmaceutical grade hydroxypropyl methylcellulose (METHOCEL K4M) was kindly donated by COLORCON (Dartford, Uk). Hydroxypropyl methylcellulose (Pharmacoat 603, Hypromellose 2910) and hypromellose acetate succinate (AQOAT-AS-LMP) were donated by Shin-Etsu (Tokyo, Japan) respectively. Caprylocaproyl macrogol-8 glyceride (Labrasol), Highly purified diethylene glycol monoethyl ether (Transcutol HP), Glycerol monocaprylocaprate (type I) (Labrafac WL1349) and Oleoyl macrogol-6 glyceride (Labrafil M 1944 CS) were kindly donated by Gattefosse (Saint-Priest, France). Tween 80 was purchased from Sigma-Aldrich (Gillingham, UK). The HPLC solvents were analytical grade and purchased from Fisher Chemicals (UK).

Kolipaka S.S., Junqueira L.A., Ross S., Garg V., Mithu M.S.H., Bhatt S, & Douroumis D. (2024). An Advanced Twin-Screw Granulation Technology: The use of Non-Volatile Solvents with High Solubilizing Capacity. AAPS PharmSciTech, 25(6).

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Metformin Quasi-Emulsion Tablet Formulation

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Metformin hydrochloride (MF, Auro Laboratories Ltd., Mumbai, India) was dissolved in demineralized water and crystallized in technical-grade acetone (density used for calculations: 0.784 g/mL at 25 °C [14 (link)]). Two types of hypromellose (HPMC, Pharmacoat^® 603, Shin-Etsu Chemical Co., Ltd., Tokyo, Japan, and Methocel™ K4M, Colorcon, Dartford, UK) were used as polymeric stabilizers of the quasi-emulsion.
For tableting, hyprolose (HPC SSL SFP, Nippon Soda, Tokyo, Japan) was used as a dry binder, and magnesium stearate (Parteck^® LUB MST, Merck KGaA, Darmstadt, Germany) as a lubricant.
Caffeine (BASF, Ludwigshafen, Germany) was used as a tracer, to determine the residence time distribution.

Hansen J, & Kleinebudde P. (2022). Increasing the Batch Size of a QESD Crystallization by Using a MSMPR Crystallizer. Pharmaceutics, 14(6), 1227.

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Controlled Release Loxoprofen Sodium Formulation

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Loxoprofen sodium (99.4% w/w) originally synthesized by Daiichi Sankyo ProPharma Co. Ltd. (Tokyo, Japan) was received as a gift sample from Hilton Pharmaceuticals (Karachi, Pakistan). Hydroxypropyl methylcellulose (Methocel K4M, K15M, and K100M), and Ethylcellulose (Ethocel 10 premium) were generously provided by Colorcon limited (Kent, United Kingdom). Sodium bicarbonate and magnesium stearate were purchased from Sigma Aldrich (Darmstadt, Germany). Hydrochloric acid (37% w/v), potassium dihydrogen phosphate (≥99.5% w/w), sodium hydroxide (≥99% w/w), acetonitrile (≥99.99% w/w), and acetone (≥99.8% w/w) were all purchased from Merck (Darmstadt, Germany). Entire chemicals and solvents used in the study were of analytical grade.

R.a.u.f.-.u.r.-.R.e.h.m.a.n., Shoaib M.H., Ahmed F.R., Yousuf R.I., Siddiqui F., Saleem M.T., Qazi F., Khan M.Z., Irshad A., Bashir L., Naz S., Farooq M, & Mahmood Z.A. (2023). SeDeM expert system with I-optimal mixture design for oral multiparticulate drug delivery: An encapsulated floating minitablets of loxoprofen Na and its in silico physiologically based pharmacokinetic modeling. Frontiers in Pharmacology, 14, 1066018.

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Formulation and Evaluation of Sustained-Release Tablet Compositions

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RIS was kindly donated by ILKO Pharmaceuticals (Istanbul, Turkey). Carbomer (CP) Carbopol^® 71G NF was kindly supported by Lubrizol (San Diego, CA, USA). Polyvinylpyrrolidone (PVP) Kollidon^® 30 was supplied by BASF (Ludwigshafen, Germany). Hydroxypropyl methylcellulose Methocel™ K4M was supplied by Colorcon (Dartford, Kent, UK). Acacia gum, chitosan (low molecular weight), guar gum (GG), hydroxyethyl cellulose (HEC), sodium alginate (SA), xanthan gum (XG), magnesium stearate, and Aerosil^® 200 were purchased from Sigma-Aldrich, Inc. (St Louis, MO, USA). Lactose monohydrate (LM) Lactopress^® spray-dried 250 was kindly gifted by DFE Pharma (Goch, Kleve, Germany). All other chemicals used in this study were of analytical grade, which were obtained from Merck (Darmstadt, Germany).

, & Çelik B. (2017). Risperidone mucoadhesive buccal tablets: formulation design, optimization and evaluation. Drug Design, Development and Therapy, 11, 3355-3365.

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