All chemicals for synthesis were purchased from Alfa Aesar (Ward Hill, MA) or Aldrich (Milwaukee, WI). The identity of the synthesized compounds was characterized by 1H and 13C NMR on a Varian (Palo Alto, CA) 400-MR spectrometer and mass spectrometer (Shimadzu LCMS-2020). The identity of the potent inhibitors was confirmed with high resolution mass spectra (HRMS) using an Agilent 6550 iFunnel quadrupole-time-of-flight (Q-TOF) mass spectrometer with electrospray ionization (ESI). The purities of the final compounds were determined to be >95% with a Shimadzu Prominence HPLC using a Zorbax C18 (or C8) column (4.6 × 250 mm) monitored by UV at 254 nm.
Agilent 6550 ifunnel quadrupole time of flight q tof mass spectrometer
Manufactured by Agilent Technologies
The Agilent 6550 iFunnel quadrupole-time-of-flight (Q-TOF) mass spectrometer is a high-performance analytical instrument designed for accurate mass measurement and identification of compounds. It combines a quadrupole mass filter with a time-of-flight mass analyzer to provide precise mass data and high-resolution separation of complex samples.
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Lab products found in correlation
2 protocols using agilent 6550 ifunnel quadrupole time of flight q tof mass spectrometer
1
Synthesis and Characterization of Potent Inhibitors
2
Characterization of Synthetic Compounds
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All chemicals for synthesis were purchased from Alfa Aesar (Ward Hill, MA) or Aldrich (Milwaukee, WI). The identity of the synthesized compounds was characterized by 1H and 13C NMR on a Varian (Palo Alto, CA) 400-MR spectrometer and mass spectrometer (Shimadzu LCMS-2020). The identity the most potent compounds was confirmed with high resolution mass spectra (HRMS) using an Agilent 6550 iFunnel quadrupole-time-of-flight (Q-TOF) mass spectrometer with electrospray ionization (ESI). The purities of the final compounds were determined to be > 95% with a Shimadzu Prominence HPLC using a Zorbax C18 (or C8) column (4.6 × 250 mm) monitored by UV at 254 nm. Synthesis and characterization of compounds can be found in Supplemental Material.
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